Publication: Ex vivo biodistribution of gallium-68-labeled porous silicon nanoparticles
Дата
2020
Авторы
Tishchenko, V. K.
Mikhailovskaya, A. A.
Smoryzanova, O. A.
Petriev, V. M.
Kabashin, A. V.
Zavestovskaya, I. N.
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© Published under licence by IOP Publishing Ltd.The introduction of nanotechnology in nuclear imaging has gained significant interest and could have promising potential for clinical use. Tumor imaging with radiolabeled nanoparticles (NPs) may be used for early detection, characterization, staging of disease, and for monitoring treatment efficacy. In this study we evaluated the biodistribution of porous silicon NPs labeled with positron-emitter gallium-68 in Wistar rats with subcutaneously transplanted cholangioma RS-1. The uptake of 68Ga-NPs in tumor tissue was 0.240.02 %ID/g at 5 min postinjection (p.i.) and climbed to 0.870.07 %ID/g at 5 h p.i. On the other hand, the amount of free 68Ga injected as 68GaCl3 solution decreased from 0.340.07 %ID/g at 5 min p.i. to 0.070.01 %ID/g at 5 h p.i. The highest level of radioactivity revealed in liver (8.27-15.79 %ID/g), spleen (0.98-1.27 %ID/g), and lungs (0.98-1.80 %ID/g). 68Ga-NPs were also determined in blood: up to 3.330.14 %ID/g at 5 min p.i. The uptake of 68Ga-NPs in other organs and tissues didn't exceed 1 %ID/g. In conclusion, the obtained results suggest that 68Ga-NPs could be suitable for use as molecular imaging probes.
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Ex vivo biodistribution of gallium-68-labeled porous silicon nanoparticles / Tishchenko, V.K. [et al.] // Journal of Physics: Conference Series. - 2020. - 1439. - № 1. - 10.1088/1742-6596/1439/1/012035