Персона:
Кабашин, Андрей Викторович

Научные группы

Научная группа

Организационные подразделения

Организационная единица

Инженерно-физический институт биомедицины

Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.

Статус

Руководитель научной группы "Лаборатория «Бионанофотоники"

Фамилия

Кабашин

Имя

Андрей Викторович

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Результаты поиска

Теперь показываю 1 - 10 из 51

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Laser-ablative synthesis and photoheating characterization of TiN NPs for biomedical applications
(2022) Popov, A. A.; Tikhonowski, G. V.; Popova-Kuznetsova, E. A.; Klimentov, S. M.; Kabashin, A. V.; Попов, Антон Александрович; Тихоновский, Глеб Валерьевич; Попова-Кузнецова, Елена Алефтиновна; Климентов, Сергей Михайлович; Кабашин, Андрей Викторович
Titanium nitride (TiN) nanoparticles (NPs) prepared by methods of laser ablation in liquids present a novel object, which promises attractive biomedical applications. Here, we review our recent advances in the elaboration of femtosecond laser ablation technique from a TiN target in liquid medium (here, isopropanol) to maximize the efficiency of TiN NPs synthesis and optimize their characteristics. Our experiments showed that the synthesis productivity is dependent on lateral velocity of laser beam scanning during laser ablation with the achievement of productivity saturation at a certain relatively high velocity. The observed phenomenon was attributed to the interaction of laser pulses with cavitation bubbles generated during the ablation process. In addition, we assessed photo heating properties of the synthesized TiN NPs in the near-IR range. It was found that TiN NPs with sizes in 20-50 nm range have the highest heating rate and can be heated to maximal temperatures. As demonstrated by our recent tests in vitro and in vivo, this size range is optimal for biomedical applications, which promises successful applications of these nanoparticles in phototherapy and imaging modalities.
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Phase-Responsive Fourier Nanotransducers for Probing 2D Materials and Functional Interfaces
(2019) Kravets, V. G.; Wu, F.; Imaizumi, S.; Grigorenko, A. N.; Kabashin, A. V.; Shipunova, V. O.; Deyev, S. M.; Кабашин, Андрей Викторович; Деев, Сергей Михайлович
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Light scattered by an object contains plethora information about the object which is distributed evenly among all possible Fourier components of light observed in the far-field. There are some cases, however, where this information is accumulated in the light confined by the object and then encoded in just a few coherent optical beams. Here, Fourier nanotransducers based on 2D plasmonic metamaterials are introduced, which are capable of confining light in 2D plane contacting with a functional interface, gathering information about its properties, and then transmitting the information into discrete optical beams with amplified phase relations. It is shown that phase of light in such beams can be used for probing dynamic physical properties of 2D materials and performing bio/chemical sensing with unprecedented sensitivity. Using a Fourier transducer based on periodic gold nanostructures, ferroelectric response from a single atomic layer of MoS 2 is resolved and studied for the first time, as well as the detection of important antibiotic chloramphenicol at fg mL −1 level is demonstrated, which several orders of magnitude better than reported in the literature. The implementation of phase-responsive Fourier nanotransducers opens new avenues in exploration of emergent 2D structures and radical improvement of biosensing technology.
Только метаданные
Bare laser-synthesized palladium-gold alloy nanoparticles as efficient electrocatalysts for glucose oxidation for energy conversion applications
(2020) Holade, Y.; Hebie, S.; Maximova, K.; Kokoh, K. B.; Sentis, M.; Delaporte, P.; Kabashin, A. V.; Кабашин, Андрей Викторович
© The Royal Society of Chemistry.Electrochemical energy converters based on biomass-based organic molecules such as glucose have recently demonstrated great potential for the development of functional bioimplantable devices such as pacemakers, but such converters lack efficient metal-based anode nanocatalysts, which could combine the stability of parameters with high performance. Here, we elaborate a technique of femtosecond laser ablation in water to synthesize bare (ligand-free) PdAu alloy nanoparticles with constituents having a variable ratio and explore these nanoparticles as electrocatalysts for glucose oxidation. Our data evidence that the combination of two metals in one bare nanoformulation can result in a strong synergetic effect, which makes the combination of high catalytic activity toward glucose oxidation with ultrafast kinetics at low potentials possible due to the presence of Au and Pd, respectively, while a bare uncontaminated surface ensures outstanding catalytic performance. We show that at an optimal ratio of constituents (50%/50%), PdAu nanoparticles can provide a mass activity of 60 A g-1 and an onset potential lower than 0.27 V vs. RHE, which outperform all currently existing nanoparticle-based electrodes. Our results show that bare nanomaterials prepared by laser-Ablation synthesis can offer much improved characteristics as electrocatalysts for energy conversion and storage applications, while the versatility of laser synthesis can be extended to other alloy architectures in order to provide optimal characteristics for a concrete catalytic process.
Только метаданные
Nonlinear photoacoustic response of suspensions of laser-synthesized plasmonic titanium nitride nanoparticles
(2020) Maldonado, M. E.; Das, A.; Gomes, A. S. L.; Popov, A. A.; Klimentov, S. M.; Kabashin, A. V.; Попов, Антон Александрович; Климентов, Сергей Михайлович; Кабашин, Андрей Викторович
© 2020 Optical Society of AmericaA nonlinear photoacoustic (PA) response from solutions of 40 nm plasmonic titanium nitride nanoparticles (NPs) synthesized by laser ablation in a liquid environment (acetone) is reported. Using a photoacoustic Z-scan with 5 ns pumping pulses, values of effective nonlinear absorption (NLA) coefficients βPA,eff were measured and found to be 3.27±0.17 × 10−8, 6.41±0.32 × 10−8, and 3.22±0.16 × 10−8 for 600, 700, and 800 nm pumping wavelengths, respectively. To take into account the influence of nonlinear scattering, absorption-dependent PA measurements were carried out together with the optical Z-scan, and the obtained data were compared. The origin of the effective absorptive nonlinearity is discussed based on combined NLA in NPs, nonlinear scattering, and bubble generation triggered by NP-mediated light absorption. Potential applications include biomedical diagnostics and therapy.
Только метаданные
Direct photoacoustic measurement of silicon nanoparticle degradation promoted by a polymer coating
(2022) Mashkovich, E. A.; Deryabin, M. S.; Kurin, V. V.; Bakunov, M. I.; Zelepukin, I. V.; Lipey, N. A.; Popov, A. A.; Shipunova, V. O.; Yu. , Griaznova, O.; Nikitin, P. I.; Kabashin, A. V.; Deyev, S. M.; Zvyagin, A. V.; Попов, Антон Александрович; Грязнова, Ольга Юрьевна; Никитин, Петр Иванович; Кабашин, Андрей Викторович; Деев, Сергей Михайлович
© 2021 Elsevier B.V.Nanomaterials with controllable biodegradation properties respond to the main challenge of cancer nanomedicine to minimise side effects and maximise the delivery efficacy to tumours. These biodegradation properties vary from clear aqueous solutions to protein-abundant biological fluids. A photoacoustic method suitable for in vitro quantification of highly scattering colloids with optical absorption properties is introduced and demonstrated by determination of the degradation rate of laser-synthesized silicon nanoparticles (Si NPs) in turbid serum solutions. In vitro screening of a variety of polymer surface-coatings of Si NPs revealed a stand-alone property of polyallylamine (PAA) to accelerate the Si NP dissolution. PAA-coated Si NP half-life was measured ∼ 100-min in aqueous solutions and slowed down to ∼ 24 h in serum. As-produced PAA-coated Si NPs appeared suitable for blockade of the mononuclear phagocyte system. Pre-treatment with PAA-Si NPs caused 1.4-times reduced uptake of magnetic particles by human THP-1 cells in vitro and a 13-fold increase of the magnetic particle delivery to the B16-F1 xenograft tumours in vivo. The demonstrated photoacoustic method is believed to facilitate design and screening of biodegradable materials suitable for in vivo applications such as controlled drug release.
Только метаданные
Plasmonic Si Au core-satellite nanoparticles prepared by laser-assisted synthesis for photothermal therapy
(2021) Al-Kattan, A.; Tselikov, G.; Popov, A. A.; Kabashin, A. V.; Попов, Антон Александрович; Кабашин, Андрей Викторович
Abstract We describe a laser-assisted methodology for the fabrication of Si@Au core-satellite nanostructures for photothermal therapy applications. The methodology consists in laser ablative synthesis of Si and Au NPs in water/ethanol solutions, followed by a chemical modification of the Si NPs by APTMS and their subsequent decoration by the Au NPs. We show that despite a relatively small size (< 40 nm) the formed core-satellites exhibit a strong plasmonic absorption peak centred around 610 nm and having a large tail over 700 nm overlapping with the first optical window of relative tissue transparency. Being relatively small and exempt of any toxic impurity due to ultraclean laser synthesis, the fabricated nanoparticles promise a major advancement of imaging and phototherapy modalities based on plasmonic properties of nanomatererials.
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High-order harmonic generation in au nanoparticle-contained plasmas
(2020) Venkatesh, M.; Ganeev, R. A.; Boltaev, G. S.; Kim, V. V.; Ivanov, D. S.; Kabashin, A. V.; Klimentov, S. M.; Иванов, Дмитрий Сергеевич; Кабашин, Андрей Викторович; Климентов, Сергей Михайлович
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.Gold nanoparticles (NPs) have a wide range of applications in various fields. Here, we present high-order nonlinear optical studies of the plasmas produced from ablation of Au bulk targets and Au NP films deposited on paper and glass substrates. Experimentally, we analyze high-order harmonic generation (HHG) from gold NPs-containing plasmas. The HHG is produced by 35-fs pulses at 800 and 400 nm, while the plasmas are produced by femtosecond (35 fs, 800 nm), picosecond (200 ps, 800 nm), and nanosecond (5 ns, 1064 nm) pulses, respectively. High-order harmonics produced from ablated Au NPs on paper were 40 times stronger than the HHG from that ablated from the Au bulk targets. Through molecular dynamic simulations, we investigate the formation of gold NPs during laser ablation of a metal surface under different conditions.
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Tungsten disulfide nanoparticles produced by femtosecond laser ablation in water for nanophotonic applications
(2021) Tselikov, G. I.; Popov, A. A.; Ermolaev, G. A.; Syuy, A. V.; Kabashin, A. V.; Arsenin, A. V.; Volkov, V. S.; Попов, Антон Александрович; Кабашин, Андрей Викторович
Abstract We demonstrate nearly spherical nanoparticles of tungsten disulfide (WS2) produced by femtosecond pulsed laser ablation of bulk target in deionized water. Structural and optical analysis reveals that produced nanospheres preserve the crystalline structure, high refractive index and support strong excitons and Mie resonances in the spectral range 400-700 nm, resulting in enhanced photothermal response probed by Raman spectroscopy.
Только метаданные
Laser-ablative synthesis of nanomaterials for nuclear and radiative medicine applications
(2022) Tikhonowski, G. V.; Popov, A. A.; Zelepukin, I.; Popova-Kuznetsova, E.; Dombrovska, Y.; Deyev, S. M.; Zavestovskaya, I. N.; Klimentov, S. M.; Prasad, P. N.; Kabashin, A. V.; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Попова-Кузнецова, Елена Алефтиновна; Деев, Сергей Михайлович; Завестовская, Ирина Николаевна; Климентов, Сергей Михайлович; Кабашин, Андрей Викторович
Newly emerging nanomaterials promise a major advancement of methods of nuclear and radiative medicine for cancer treatment, as they can be used as carriers of diagnostic or therapeutic radionuclides, contrast agents in nuclear imaging modalities (PET, SPECT) or sensitizers of radiative therapies (X-ray, ion beams, etc.). However, nanotechnology-based approaches have reported a limited success so far due to a lack of suitable functional nanoformulations, which are safe, non-toxic, excretable from the body and have favorable pharmacokinetics for effective accumulation in the tumor. As follows from the results of our on-going research activities, many of the above-stated problems can we solved by the employment of nanomaterials fabricated by clean laser-ablative synthesis. Here, we review our recent data on some promising nanomaterials, prepared by this method, including biodegradable silicon (Si) nanoparticles (NPs), Sm-152-enriched samarium oxide NPs, and elemental bismuth (Bi) NPs, which can be used either as carriers/agents in radionuclide therapy, or sensitizers in radiative diagnostics or therapy. Advantages of proposed approach include exceptional purity and flexibility in synthesizing of NPs of required physico-chemical parameters (controlled size, shape, composition, and surface conditioning of NPs). Advances in laser-ablative fabrication of novel nanomaterials open up avenues for future implementations of nuclear and radiative medicine approaches for safe and efficient theranostics of tumors and metastasis.
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Bare laser-synthesized plasmonic Au and TiN nanoparticles as functional additives to polymer nanofiber platforms for tissue engineering applications
(2021) Al-Kattan, A.; Kabashin, A. V.; Кабашин, Андрей Викторович
© 2021 Institute of Physics Publishing. All rights reserved.Exhibiting strong optical absorption in the visible - near-infrared, plasmonic nanomaterials can be used as transducers in optical biosensing, contrast agents in bioimaging and synthesizers of photothermal therapy. Such functionalities promise their employment as functional elements in tissue engineering platforms, but such applications typically require ultraclean nanomaterials to minimize toxicity problems, which is not easy using conventional chemical synthesis routes. We recently demonstrated the possibility of fabricating ultraclean bare (ligand-free) plasmonic Au and TiN nanoparticles by ultrashort laser ablation in liquid ambient. Exempt of any toxic contaminants and exhibiting a series of imaging and therapeutic functionalities, these nanomaterials present promising objects for various biomedical applications. Here, we review our recent progress in the co-electrospinning of laser-synthesized Au and TiN nanoparticles with polymers to form functionalized matrices for tissue engineering.