Publication:
Ex vivo biodistribution of gallium-68-labeled porous silicon nanoparticles

Простая страница элемента
dc.contributor.authorTishchenko, V. K.
dc.contributor.authorMikhailovskaya, A. A.
dc.contributor.authorSmoryzanova, O. A.
dc.contributor.authorPetriev, V. M.
dc.contributor.authorKabashin, A. V.
dc.contributor.authorZavestovskaya, I. N.
dc.contributor.authorКабашин, Андрей Викторович
dc.contributor.authorЗавестовская, Ирина Николаевна
dc.date.accessioned2024-11-25T16:12:28Z
dc.date.available2024-11-25T16:12:28Z
dc.date.issued2020
dc.description.abstract© Published under licence by IOP Publishing Ltd.The introduction of nanotechnology in nuclear imaging has gained significant interest and could have promising potential for clinical use. Tumor imaging with radiolabeled nanoparticles (NPs) may be used for early detection, characterization, staging of disease, and for monitoring treatment efficacy. In this study we evaluated the biodistribution of porous silicon NPs labeled with positron-emitter gallium-68 in Wistar rats with subcutaneously transplanted cholangioma RS-1. The uptake of 68Ga-NPs in tumor tissue was 0.240.02 %ID/g at 5 min postinjection (p.i.) and climbed to 0.870.07 %ID/g at 5 h p.i. On the other hand, the amount of free 68Ga injected as 68GaCl3 solution decreased from 0.340.07 %ID/g at 5 min p.i. to 0.070.01 %ID/g at 5 h p.i. The highest level of radioactivity revealed in liver (8.27-15.79 %ID/g), spleen (0.98-1.27 %ID/g), and lungs (0.98-1.80 %ID/g). 68Ga-NPs were also determined in blood: up to 3.330.14 %ID/g at 5 min p.i. The uptake of 68Ga-NPs in other organs and tissues didn't exceed 1 %ID/g. In conclusion, the obtained results suggest that 68Ga-NPs could be suitable for use as molecular imaging probes.
dc.identifier.citationEx vivo biodistribution of gallium-68-labeled porous silicon nanoparticles / Tishchenko, V.K. [et al.] // Journal of Physics: Conference Series. - 2020. - 1439. - № 1. - 10.1088/1742-6596/1439/1/012035
dc.identifier.doi10.1088/1742-6596/1439/1/012035
dc.identifier.urihttps://www.doi.org/10.1088/1742-6596/1439/1/012035
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85079089761&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/20265
dc.relation.ispartofJournal of Physics: Conference Series
dc.titleEx vivo biodistribution of gallium-68-labeled porous silicon nanoparticles
dc.typeConference Paper
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume1439
relation.isAuthorOfPublicationb79a080b-900d-4655-ba2e-53fd552b3a15
relation.isAuthorOfPublication1a1d2a9c-068f-48c6-b18a-7da3ce75cf7a
relation.isAuthorOfPublication.latestForDiscoveryb79a080b-900d-4655-ba2e-53fd552b3a15
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
Файлы
Original bundle
Теперь показываю 1 - 1 из 1
Уменьшенное изображение
Name:
W2999944886.pdf
Size:
504.32 KB
Format:
Adobe Portable Document Format
Description:
Download
Коллекции
Публикации