Publication: Experimental Study of the Biodistribution of New Bone-Seeking Compounds Based on Phosphonic Acids and Gallium-68
Дата
2020
Авторы
Tishchenko, V. K.
Petriev, V. M.
Mikhailovskaya, A. A.
Stepchenkova, E. D.
Timoshenko, V. Y.
Postnov, A. A.
Zavestovskaya, I. N.
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Аннотация
We investigate biodistribution of gallium-labeled hydroxyethylidenediphosphonic acid (Ga-68-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) (Ga-68-DTPMP) in intact Wistar rats. It was shown that Ga-68-DTPMP accumulated mainly in the bone tissue providing high femur/blood and femur/muscle ratios and had high stability in vivo. In contrast, Ga-68-HEDP was characterized by low stability and high uptake of radioactivity in blood throughout the study. So Ga-68-DTPMP can be considered as a new prospective radiotracer in oncology for imaging bone tissue metastasis by positron emission tomography.
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Цитирование
Experimental Study of the Biodistribution of New Bone-Seeking Compounds Based on Phosphonic Acids and Gallium-68 / Tishchenko, VK [et al.] // Bulletin of Experimental Biology and Medicine. - 2020. - 10.1007/s10517-020-04800-1
URI
https://www.doi.org/10.1007/s10517-020-04800-1
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https://openrepository.mephi.ru/handle/123456789/21590
https://www.scopus.com/record/display.uri?eid=2-s2.0-85084130071&origin=resultslist
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000528413100004
https://openrepository.mephi.ru/handle/123456789/21590