Персона: Тимошенко, Виктор Юрьевич
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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- ПубликацияТолько метаданныеMonitoring the Temperature of Silicon Nanoparticles in Liquid using Raman Scattering Excited by Nanosecond Pulsed Laser Radiation(2023) Pokryshkin, N. S.; Kuchumov, I. D.; Yakunin, V. G.; Timoshenko, V. Y.; Тимошенко, Виктор Юрьевич
- ПубликацияТолько метаданныеCarbon Nanodots Obtained by Microwave Synthesis: Physical Properties and Assessment of Cytotoxicity on a Model of Glioblastoma and Embryonal Kidney In Vitro(2023) Kopylov, A. N.; Musaeva, D. U.; Alekseeva, A. I.; Zakharkiv, A. Y.; Timoshenko, V. Y.; Копылов, Алексей Николаевич; Мусаева, Дария Уланбековна; Захаркив, Анастасия Юрьевна; Тимошенко, Виктор Юрьевич
- ПубликацияТолько метаданныеModification of Silicon Nanostructures by Cold Atmospheric Pressure Plasma Jets(2023) Pokryshkin, N. S.; Yakunin, V. G.; Efimova, A. I.; Timoshenko, V. Y.; Тимошенко, Виктор ЮрьевичCold atmospheric plasma (CAP) jets with helium (He) and argon (Ar) plasma-forming gases were used to modify the structure, photoluminescence (PL), and electrical properties of arrays of silicon nanowires (SiNWs) with initial cross-section sizes of the order of 100 nm and length of about 7‒8 microns. The CAP source consisted of a 30 kHz voltage generator with a full power up to 5 W and the CAP treatment for 1‒5 min resulted in spattering of SiNWs’ tips followed by redeposition of silicon atoms. An increase of the silicon oxide phase and a decrease of the PL intensity were observed in the plasma processed SiNW arrays. A decrease of the free hole concentration and an increase in the free electron density were revealed in heavily boron and phosphorous doped SiNWs, respectively, as it was monitored by means of the Raman spectroscopy, considering a coupling of the light scattering by phonon and free charge carriers (Fano effect) in SiNWs. The obtained results demonstrate that the CAP treatment can be used to change the length, sharpness, luminescence intensity, and electrical properties of silicon nanowires for possible applications in optoelectronics and sensorics.
- ПубликацияТолько метаданныеPlasmonic Properties of Halloysite Nanotubes with Immobilized Silver Nanoparticles for Applications in Surface-Enhanced Raman Scattering(2019) Kornilova, A. V.; Gorbachevskii, M. V.; Kuralbayeva, G. A.; Jana, S.; Timoshenko, V. Y.; Тимошенко, Виктор Юрьевич© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Halloysite nanotubes (HNTs) with surface-immobilized silver (Ag) nanoparticles (NPs) are explored as nano-templates for the surface-enhanced Raman scattering (SERS). The structure and plasmonic properties of HNTs/Ag nanocomposite during storage in water are checked by means of the transmission electron microscopy and optical absorption spectroscopy, respectively. A remarkable SERS response is observed for and the SERS activity of HNTs/Ag stored in water for 1 week decreases by several times. The observed SERS-activity is explained by desired morphology of Ag NP distribution on the surface of HNTs, which is modified during storage in aqueous medium. The revealed SERS activity of HNTs/Ag nanocomposites seems to be promising for their application in biosensorics.
- ПубликацияТолько метаданныеTemperature oscillations during photoinduced heating of aqueous suspensions of silicon nanoparticles(2021) Belov, V. S.; Bobkov, E. A.; Oleschenko, V. A.; Kabashin, A. V.; Timoshenko, V. Yu.; Белов, Владимир Сергеевич; Бобков, Егор Андреевич; Кабашин, Андрей Викторович; Тимошенко, Виктор Юрьевич© 2021 Institute of Physics Publishing. All rights reserved.Temperature oscillations (pulsations) were detected in aqueous suspensions of silicon (Si) nanoparticles NPs under laser irradiation with highly absorbed light. The temperature pulsation frequency was found to depend on the NPs concentration in suspension and laser irradiation power. The observed phenomenon is assumed to be caused by the local overheating of Si NPs close to the boiling point of water, while the average heating of the surrounding liquid was insignificant. The observed phenomenon is discussed in view of potential applications in local photo-induced hyperthermia of cancer.
- ПубликацияТолько метаданныеPhotothermal effects and heat conduction in nanogranular silicon films(2021) Kurbanova, B. A.; Utegulov, Z. N.; Mussabek, G. K.; Timoshenko, V. Y.; Lysenko, V.; Тимошенко, Виктор Юрьевич© 2021 by the authors. Licensee MDPI, Basel, Switzerland.We present results on the photothermal (PT) and heat conductive properties of nanogranu-lar silicon (Si) films synthesized by evaporation of colloidal droplets (drop-casting) of 100 ± 50 nm-sized crystalline Si nanoparticles (NP) deposited on glass substrates. Simulations of the absorbed light intensity and photo-induced temperature distribution across the Si NP films were carried out by using the Finite difference time domain (FDTD) and finite element mesh (FEM) modeling and the obtained data were compared with the local temperatures measured by micro-Raman spectroscopy and then was used for determining the heat conductivities k in the films of various thicknesses. The cubic-to-hexagonal phase transition in Si NP films caused by laser-induced heating was found to be heavily influenced by the film thickness and heat-conductive properties of glass substrate, on which the films were deposited. The k values in drop-casted Si nanogranular films were found to be in the range of lowest k of other types of nanostructurely voided Si films due to enhanced phonon scattering across inherently voided topology, weak NP-NP and NP-substrate interface bonding within nanogranular Si films.
- ПубликацияТолько метаданныеStabilization of porous silicon nanoparticles by PEGalization in water(2021) Eremina, A. S.; Kharin, A. Yu.; Kargina, Yu. V.; Timoshenko, V. Yu.; Еремина, Анна Сергеевна; Тимошенко, Виктор Юрьевич© 2021 Institute of Physics Publishing. All rights reserved.Mesoporous silicon (mPSi) nanoparticles (NPs) are stabilized by polyethylene glycol (PEG) chains during mechanical grinding in a ball mill that is used to form mPSi-PEG-NPs. The structure, composition, and properties of the obtained samples are studied by means of the dynamic light scattering, scanning electron microscopy and Fourier-transform infrared spectroscopy. The proposed PEGalization procedure is an effective way of regulating the dissolution of mPSi-NPs in water and it is promising for potential application of mPSi-NPs in drug delivery.
- ПубликацияТолько метаданныеMethods of medical visualization and thermal ablation as a new approach to treatment of hyperparathyroidism(2021) Rumyantsev, P. O.; Bubnov, A. A.; Дегтярев, М. В.; Слащук, К. Ю.; Захарова, С. М.; Агибалов, Д. Ю.; Timoshenko, V. Y.; Тимошенко, Виктор Юрьевич
- ПубликацияТолько метаданныеEffect of Low-Temperature Atmospheric Pressure Plasma on Paramecium caudatum Cell Culture(2021) Gruzdev, G. A.; Karpukhina, O. V.; Yakunin, V. G.; Inozemtsev, A. N.; Timoshenko, V. Y.; Тимошенко, Виктор Юрьевич© 2021, Allerton Press, Inc.Abstract: Influence of low-temperature atmospheric pressure plasma generated by a high-resource arc plasmatron in an air mixture with the addition of an inert gas and in pure inert gas on the culture of Paramecium caudatum cells was studied. The effect of the plasma composition and the time of its exposure on the level of acidity of the aqueous medium and the nature of cell death was found. The obtained results are discussed taking into account the effect of active radicals formed under the action of a plasma jet as well as the delayed reaction of cells to plasma exposure.
- ПубликацияТолько метаданныеOptical properties of dextran-stabilized silicon nanoparticles in aqueous medium(2021) Kharin, A. Yu.; Timoshenko, V. Yu.; Тимошенко, Виктор ЮрьевичSilicon nanoparticles (Si-NPs) with initial sizes of the order of 100 nm were prepared by femtosecond laserablation-fragmentation of microcrystalline silicon in water followed by drying and resuspending in wateror in aqueous solutions of dextran. The prepared aqueous suspensions of Si-NPs without dextran and withdextran coating were investigated by means of the scanning electron microscopy, dynamic light scatteringand optical absorption spectroscopy in the spectral range from 250 to 800 nm. The optical absorption ofuncoated Si-NPs in an aqueous medium with different pH-level varied from 4 to 8 was found to decreasewith time because of a process of the dissolution of those NPs in water. The dissolution rate dependednonmonotonically on the solution acidity (pH level) and the corresponding times were in the range from 50to 180 hours. The addition of dextran into the solution was found to significantly decrease the dissolutionrate of Si-NPs to 300 hours because of the coating of NPs with a polymer shell. The obtained results canbe useful to develop new biomedical technologies involving Si-NPs as stabilized theranostics (therapy anddiagnostics) agents. Key words: nanoparticles, dextran, biopolymer, optics, absorbance.