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Тимошенко, Виктор Юрьевич

Организационные подразделения

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Инженерно-физический институт биомедицины

Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.

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Тимошенко

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Виктор Юрьевич

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Stabilization of porous silicon nanoparticles by PEGalization in water
(2021) Eremina, A. S.; Kharin, A. Yu.; Kargina, Yu. V.; Timoshenko, V. Yu.; Еремина, Анна Сергеевна; Тимошенко, Виктор Юрьевич
© 2021 Institute of Physics Publishing. All rights reserved.Mesoporous silicon (mPSi) nanoparticles (NPs) are stabilized by polyethylene glycol (PEG) chains during mechanical grinding in a ball mill that is used to form mPSi-PEG-NPs. The structure, composition, and properties of the obtained samples are studied by means of the dynamic light scattering, scanning electron microscopy and Fourier-transform infrared spectroscopy. The proposed PEGalization procedure is an effective way of regulating the dissolution of mPSi-NPs in water and it is promising for potential application of mPSi-NPs in drug delivery.
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Experimental Study of the Biodistribution of New Bone-Seeking Compounds Based on Phosphonic Acids and Gallium-68
(2020) Tishchenko, V. K.; Petriev, V. M.; Mikhailovskaya, A. A.; Stepchenkova, E. D.; Timoshenko, V. Y.; Postnov, A. A.; Zavestovskaya, I. N.; Тимошенко, Виктор Юрьевич; Завестовская, Ирина Николаевна
We investigate biodistribution of gallium-labeled hydroxyethylidenediphosphonic acid (Ga-68-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) (Ga-68-DTPMP) in intact Wistar rats. It was shown that Ga-68-DTPMP accumulated mainly in the bone tissue providing high femur/blood and femur/muscle ratios and had high stability in vivo. In contrast, Ga-68-HEDP was characterized by low stability and high uptake of radioactivity in blood throughout the study. So Ga-68-DTPMP can be considered as a new prospective radiotracer in oncology for imaging bone tissue metastasis by positron emission tomography.
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Carbon Nanodots Obtained by Microwave Synthesis: Physical Properties and Assessment of Cytotoxicity on a Model of Glioblastoma and Embryonal Kidney In Vitro
(2023) Kopylov, A. N.; Musaeva, D. U.; Alekseeva, A. I.; Zakharkiv, A. Y.; Timoshenko, V. Y.; Копылов, Алексей Николаевич; Мусаева, Дария Уланбековна; Захаркив, Анастасия Юрьевна; Тимошенко, Виктор Юрьевич
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Acceleration of the Decay of Excitons in an Organometallic Perovskite Film on the Crystalline Silicon Surface
(2019) Sekerbayev, K. S.; Taurbayev, Y. T.; Ionin, A. A.; Saraeva, I. N.; Kudryashov, S. I.; Timoshenko, V. Y.; Тимошенко, Виктор Юрьевич
© 2019, Pleiades Publishing, Inc.It has been found that the optical properties and characteristics of exciton photoluminescence in thin organometallic perovskite layers, which are promising for application in high-efficiency solar cells, change when these layers are deposited on a crystalline silicon (c-Si) substrate. The observed shift of the photoluminescence band toward higher photon energies and a decrease in the lifetime of photoluminescence compared to layers deposited on a glass substrate with conducting metal oxide coating have been explained by the effect of an electric field that is formed in an organometallic perovskite/c-Si heterostructure and leads to the field ionization and the decay of excitons in the organometallic perovskite layer.
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Gold nanoparticles immobilized on halloysite nanotubes for spatially-temporally localized photohyperthermia
(2021) Kornilova, A. V.; Kuralbayeva, G. A.; Stavitskaya, A. V.; Gorbachevskii, M. V.; Timoshenko, V. Y.; Тимошенко, Виктор Юрьевич
© 2021 Elsevier B.V.Halloysite nanotubes (HNTs) with immobilized gold (Au) nanoparticles (NPs) were explored to enhance photoheating of aqueous media under excitation by continuous wave (CW) and nanosecond pulsed lasers with wavelengths close to the plasmonic resonance of Au-NPs. The structure and plasmonic properties of HNTs/Au-NP nanocomposites were analyzed by means of the transmission electron microscopy and optical spectroscopy. A remarkable photothermal effect with initial temperature growth of about 0.5 °C/min was observed for HNTs/Au-NPs’ aqueous suspension under relatively low excitation intensity, while the same photoexcitation of bare HNTs’ aqueous suspension did not result in any noticeable heating. In vitro experiments with Paramecium caudatum unicellular organisms have revealed a strong suppression of the cell viability after photoexcitation. While the average photoheating effect did not exceed 3–4 °C, the cell viability was decreased multifold, especially for the pulsed photoexcitation. The experimental results are explained by the spatially and temporally localized photohyperthermia in the vicinity of Au-NPs. The observed photoheating of HNTs/Au-NP nanocomposite is promising for applications in antibacterial treatment and targeted cancer therapy.
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Photoacoustic characterization of nanowire arrays formed by metal-assisted chemical etching of crystalline silicon substrates with different doping level
(2019) Lishchuk, P.; Isaiev, M.; Osminkina, L.; Burbelo, R.; Timoshenko, V.; Тимошенко, Виктор Юрьевич
© 2018 Elsevier B.V. Silicon nanowire (SiNW) arrays were investigated by gas-microphone photoacoustic (PA) technique to evaluate the thermal conductivity and optical absorption. The arrays with SiNW's length from 3 to 25 μm were formed by metal-assisted chemical etching of (100)-oriented monocrystalline silicon (c-Si) substrates with the low and high concentration of doping impurities. PA responses of SiNWs were excited by sources with wavelengths of 460 and 630 nm in the frequency range from 15 to 1150 Hz. An analysis of the experimental data reveals that the thermal conductivities of SiNWs formed on the lightly and heavily doped substrates are about 4–7 and 0.17–0.22 W/(m K), respectively. The latter value is explained by the porous structure of the SiNWs, promoting a strong restriction of the phonon free path. The thermal conductivity and optical absorption of SiNW arrays depend on the doping level and length of SiNWs due to a combination of the phonon and light scattering processes.
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Application of cold plasma to control the microbiota composition on the surface of potato tubers
(2021) Golovin, M. L.; Orlova, V. S.; Mazina, S. E.; Yakunin, V. G.; Timoshenko, V. Y.; Тимошенко, Виктор Юрьевич
© The Authors, published by EDP Sciences, 2021.A study of the effect of low-temperature plasma on potato tubers was carried out. A comparative assessment of changes in the rate of germination, the size of shoots and the mass of shoots was carried out. Changes in the number of bacteria and fungi on the surface of tubers were analysed for different durations of exposure. It was found that growth characteristics did not change. The number of bacteria on the surface of tubers was significantly reduced due to the exposure to low-temperature plasma.
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СРАВНИТЕЛЬНОЕ ИССЛЕДОВАНИЕ ЭФФЕКТИВНОСТИ ФОТОТЕРМИЧЕСКОЙ КОНВЕРСИИ В ВОДНЫХ СУСПЕНЗИЯХ НАНОЧАСТИЦ НА ОСНОВЕ КРЕМНИЯ И НИТРИДА ТИТАНА ДЛЯ БИОМЕДИЦИНСКИХ ПРИМЕНЕНИЙ
(НИЯУ МИФИ, 2025) Бубнов, А. А.; Сюй, А. В.; Попов, А. А.; Тихоновский, Г. В.; Покрышкин, Н. С.; Тимошенко, В. Ю.; Тихоновский, Глеб Валерьевич; Тимошенко, Виктор Юрьевич; Бубнов, Александр Андреевич; Попов, Антон Александрович
В работе представлены результаты экспериментов по изучению лазерно-стимулированного нагрева в ближней инфракрасной области спектра водных суспензий наночастиц (НЧ) на основе кремния (Si и Si–Fe НЧ) и нитрида титана (TiN НЧ) непрерывным лазером с длиной волны 808 нм и мощностью 0.36 мВт. Получены температурные профили, определена скорость нагрева и фототермическая конверсионная эффективность для каждого образца при концентрации 1 мг/мл. Значения конверсионных эффективностей для исследуемых водных суспензий TiN, Si–Fe и Si НЧ составили 90, 36 и 10% соответственно. Полученные результаты показывают, что TiN и Si–Fe НЧ могут быть применены в качестве фотоагентов для контроля локальной фотогипертермии в биомедицине.
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Vibrational Analysis of Silicon Nanoparticles Using Simulation and Decomposition of Raman Spectra
(2020) Povarnitsyn, M. E.; Shcheblanov, N. S.; Ivanov, D. S.; Timoshenko, V. Y.; Klimentov, S. M.; Тимошенко, Виктор Юрьевич; Климентов, Сергей Михайлович
We report a classical molecular-dynamics simulation of models of silicon nanoparticles and bulk sili-con, in both the crystalline and the amorphous phase, to investigate their vibrational properties. By using a dynamical-matrix approach and a bond-polarizability model, together with a Raman-decomposition approach [Phys. Rev. B 100, 134309 (2019)], we present a comprehensive analysis of the vibrational spec-tra. In particular, the dependence of the high-frequency range of the Raman spectra on the nanoparticle size is studied. The results are in good agreement with Raman measurements on crystalline nanoparticles and explain the role of the nanoparticle surface, which is responsible for a shift in the Raman spectrum dependent on the particle size. In the low-frequency range, our Raman calculations reproduce well the Lamb-mode signatures, which obey the selection rules deduced by Duval [Phys. Rev. B 46, 5795 (1992)]. As a result of systematic Raman modeling, we confirm the scaling of the main signatures (ascribed to the Lamb modes with l = 0, 2) with respect to the nanoparticle size. By using the Raman-decomposition approach, we demonstrate that only a thin surface layer several angstroms in thickness contributes to the low-frequency Raman signature regardless of the nanoparticle size in the case of both the amorphous and the crystalline phase. Finally, we study the role of the coordination number of the atoms in the surface layer of a nanoparticle in order to explain the difference between the crystalline and amorphous vibrational spectra. The approach developed provides knowledge necessary for the correct interpretation of Raman spectra of nanoparticles, which opens up the possibility of quantitative control of surface-induced effects that may be relevant to various applications.
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Methods of medical visualization and thermal ablation as a new approach to treatment of hyperparathyroidism
(2021) Rumyantsev, P. O.; Bubnov, A. A.; Дегтярев, М. В.; Слащук, К. Ю.; Захарова, С. М.; Агибалов, Д. Ю.; Timoshenko, V. Y.; Тимошенко, Виктор Юрьевич