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Experimental Study of the Biodistribution of New Bone-Seeking Compounds Based on Phosphonic Acids and Gallium-68

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dc.contributor.authorTishchenko, V. K.
dc.contributor.authorPetriev, V. M.
dc.contributor.authorMikhailovskaya, A. A.
dc.contributor.authorStepchenkova, E. D.
dc.contributor.authorTimoshenko, V. Y.
dc.contributor.authorPostnov, A. A.
dc.contributor.authorZavestovskaya, I. N.
dc.contributor.authorТимошенко, Виктор Юрьевич
dc.contributor.authorЗавестовская, Ирина Николаевна
dc.date.accessioned2024-11-26T12:35:25Z
dc.date.available2024-11-26T12:35:25Z
dc.date.issued2020
dc.description.abstractWe investigate biodistribution of gallium-labeled hydroxyethylidenediphosphonic acid (Ga-68-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) (Ga-68-DTPMP) in intact Wistar rats. It was shown that Ga-68-DTPMP accumulated mainly in the bone tissue providing high femur/blood and femur/muscle ratios and had high stability in vivo. In contrast, Ga-68-HEDP was characterized by low stability and high uptake of radioactivity in blood throughout the study. So Ga-68-DTPMP can be considered as a new prospective radiotracer in oncology for imaging bone tissue metastasis by positron emission tomography.
dc.identifier.citationExperimental Study of the Biodistribution of New Bone-Seeking Compounds Based on Phosphonic Acids and Gallium-68 / Tishchenko, VK [et al.] // Bulletin of Experimental Biology and Medicine. - 2020. - 10.1007/s10517-020-04800-1
dc.identifier.doi10.1007/s10517-020-04800-1
dc.identifier.urihttps://www.doi.org/10.1007/s10517-020-04800-1
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85084130071&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000528413100004
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/21590
dc.relation.ispartofBulletin of Experimental Biology and Medicine
dc.titleExperimental Study of the Biodistribution of New Bone-Seeking Compounds Based on Phosphonic Acids and Gallium-68
dc.typeArticle
dspace.entity.typePublication
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