Publication: MIL-53 (Al) metal-organic frameworks as potential drug carriers
Дата
2021
Авторы
Kolokolnikov, V. N.
Griaznova, O. Yu.
Zelepukin, I. V.
Tikhonowski, G. V.
Deyev, S. M.
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© 2021 Institute of Physics Publishing. All rights reserved.One of the challenges of the medicine is to improve the chemical stability of drugs and to prevent their premature biodegradation before reaching the therapeutic target. Various nanoparticles were used to solve this problem, but low drug loading efficiency limited their biomedical applications. Metal organic frameworks are promising candidates for drug delivery since they have extremely high surface area and regular porosity. In this study, we prepared high-crystalline MIL-53 frameworks based on aluminium and 2-aminoterephtalic acid by microwave-assisted synthesis and evaluated their properties as drug carriers. Drug loading of chemotherapeutic and diagnostic molecules of different nature riches value of 34% by particle weight, significantly higher than those of other reported solid nanoparticles. Therefore, our results make MIL-53 (Al) frameworks promising candidate for drug delivery.
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MIL-53 (Al) metal-organic frameworks as potential drug carriers / Kolokolnikov, V.N. [et al.] // Journal of Physics: Conference Series. - 2021. - 2058. - № 1. - 10.1088/1742-6596/2058/1/012015