Персона: Тихоновский, Глеб Валерьевич
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Глеб Валерьевич
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44 results
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Теперь показываю 1 - 10 из 44
- ПубликацияТолько метаданныеLaser-synthesized plasmonic HfN-based nanoparticles as a novel multifunctional agent for photothermal therapy(2024) Pastukhov, A. I.; Savinov, M. S.; Zelepukin, I. V.; Babkova, J. S.; Tikhonowski, G. V.; Popov, A. A.; Klimentov, S. M.; Zavestovskaya, I. N.; Deyev, S. M.; Kabashin, A. V.; Савинов, Максим Сергеевич; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Климентов, Сергей Михайлович; Завестовская, Ирина Николаевна; Деев, Сергей Михайлович; Кабашин, Андрей ВикторовичHfN nanoparticles exhibiting a tunable plasmonic feature in the near-IR were synthesized by laser ablation in liquids. A strong photothermal therapeutic effect yielding 100% cells death under 808 nm irradiation of nanoparticles was reported.
- ПубликацияТолько метаданныеBismuth nanoparticles-enhanced proton therapy: Concept and biological assessment(2024) Zavestovskaya, I. N.; Tikhonowski, G. V.; Savinov, M.; Shakhov, P. V.; Popov, A. A.; Klimentov, S. M.; Deyev, S. M.; Завестовская, Ирина Николаевна; Тихоновский, Глеб Валерьевич; Савинов, Максим Сергеевич; Шахов, Павел Владимирович; Попов, Антон Александрович; Климентов, Сергей Михайлович; Деев, Сергей Михайлович
- ПубликацияТолько метаданныеBinary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles(2024) Filimonova, M. V.; Tikhonowski, G. V.; Petrunya, D. S.; Popov, A. A.; Savinov, M. S.; Lipengolts, A. A.; Shpakova, K. E.; Koryakin, S. N.; Zavestovskaya, I. N.; Тихоновский, Глеб Валерьевич; Петруня, Дмитрий Сергеевич; Попов, Антон Александрович; Савинов, Максим Сергеевич; Липенгольц, Алексей Андреевич; Завестовская, Ирина Николаевна
- ПубликацияТолько метаданныеLaser-synthesized TiN-based nanoparticles as novel efficient electrostatic nanosorbent for environmental water cleaning(2024) Syuy, A. V.; Martynov, I. V.; Zavidovskiy, I. A.; Tikhonowski, G. V.; Tselikov, D. I.; Savinov, M. S.; Sozaev, I. V.; Popov, A. A.; Klimentov, S. M.; Тихоновский, Глеб Валерьевич; Целиков, Даниил Игоревич; Савинов, Максим Сергеевич; Созаев, Ислам Владимирович; Попов, Антон Александрович; Климентов, Сергей Михайлович
- ПубликацияТолько метаданныеUltrafast laser ablation of gold in liquids: Effect of laser pulse overlap-induced surface porosity on size distribution of formed nanoparticles(2024) Ivanov, D. S.; Shakhov, P.; Tikhonowsky, G.; Popov, A. A.; Mayorov, A. N.; Zavestovskaya, I. N.; Klimentov, S. M.; Шахов, Павел Владимирович; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Майоров, Алексей Николаевич; Завестовская, Ирина Николаевна; Климентов, Сергей Михайлович
- ПубликацияОткрытый доступLaser-Synthesized Germanium Nanoparticles as Biodegradable Material for Near-Infrared Photoacoustic Imaging and Cancer Phototherapy(2024) Belyaev, I. B.; Zelepukin, I. V.; Kotelnikova, P. A.; Tikhonowski, G. V.; Popov, A. A.; Kopylov, A. N.; Deyev, S. M.; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Копылов, Алексей Николаевич; Деев, Сергей МихайловичAbstract Biodegradable nanomaterials can significantly improve the safety profile of nanomedicine. Germanium nanoparticles (Ge NPs) with a safe biodegradation pathway are developed as efficient photothermal converters for biomedical applications. Ge NPs synthesized by femtosecondў??laser ablation in liquids rapidly dissolve in physiologicalў??like environment through the oxidation mechanism. The biodegradation of Ge nanoparticles is preserved in tumor cells in vitro and in normal tissues in mice with a halfў??life as short as 3.5 days. Biocompatibility of Ge NPs is confirmed in vivo by hematological, biochemical, and histological analyses. Strong optical absorption of Ge in the nearў??infrared spectral range enables photothermal treatment of engrafted tumors in vivo, following intravenous injection of Ge NPs. The photothermal therapy results in a 3.9ў??fold reduction of the EMT6/P adenocarcinoma tumor growth with significant prolongation of the mice survival. Excellent massў??extinction of Ge NPs (7.9 L g ў??1 cm ў??1 at 808 nm) enables photoacoustic imaging of bones and tumors, following intravenous and intratumoral administrations of the nanomaterial. As such, strongly absorbing nearў??infraredў??light biodegradable Ge nanomaterial holds promise for advanced theranostics.
- ПубликацияТолько метаданныеEffect of Oxygen on Colloidal Stability of Titanium Nitride Nanoparticles Synthesized by Laser Ablation in Liquids(2021) Tikhonowski, G. V.; Popova-Kuznetsova, E. A.; Aleshchenko, Y. A.; Klimentov, S. M.; Kabashin, A. V.; Popov, A. A.; Тихоновский, Глеб Валерьевич; Попова-Кузнецова, Елена Алефтиновна; Алещенко, Юрий Анатольевич; Климентов, Сергей Михайлович; Кабашин, Андрей Викторович; Попов, Антон Александрович© 2021, Allerton Press, Inc.Abstract: The effect of oxygen existing in an ablation medium during synthesis of titanium nitride (TiN) nanoparticles (NPs) by pulsed laser ablation in liquid (PLAL) on colloidal stability of obtained solutions was studied. It was shown that an increase in the oxygen content both incorporated in liquid molecules and in the form of dissolved gas increases the colloidal stability of synthesized NPs. The results obtained extend the range of available methods for developing new nanomaterials due to control of colloidal stability of laser-synthesized NPs.
- ПубликацияТолько метаданныеMIL-53 (Al) metal-organic frameworks as potential drug carriers(2021) Kolokolnikov, V. N.; Griaznova, O. Yu.; Zelepukin, I. V.; Tikhonowski, G. V.; Deyev, S. M.; Грязнова, Ольга Юрьевна; Тихоновский, Глеб Валерьевич; Деев, Сергей Михайлович© 2021 Institute of Physics Publishing. All rights reserved.One of the challenges of the medicine is to improve the chemical stability of drugs and to prevent their premature biodegradation before reaching the therapeutic target. Various nanoparticles were used to solve this problem, but low drug loading efficiency limited their biomedical applications. Metal organic frameworks are promising candidates for drug delivery since they have extremely high surface area and regular porosity. In this study, we prepared high-crystalline MIL-53 frameworks based on aluminium and 2-aminoterephtalic acid by microwave-assisted synthesis and evaluated their properties as drug carriers. Drug loading of chemotherapeutic and diagnostic molecules of different nature riches value of 34% by particle weight, significantly higher than those of other reported solid nanoparticles. Therefore, our results make MIL-53 (Al) frameworks promising candidate for drug delivery.
- ПубликацияТолько метаданныеCytotoxicity of Laser-Synthesized Nanoparticles of Elemental Bismuth(2024) Shakhov, P. V.; Tikhonowski, G. V.; Popov, A. A.; Iliasov, A. R.; Lebedev, A. A.; Klimentov, S. M.; Шахов, Павел Владимирович; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Илясов, Артём Романович; Лебедев, Анатолий Алексеевич; Климентов, Сергей Михайлович
- ПубликацияТолько метаданныеBoron Nanoparticle-Enhanced Proton Therapy: Molecular Mechanisms of Tumor Cell Sensitization(2024) Popov, A. L.; Kolmanovich, D. D.; Chukavin, N. N.; Zelepukin, I. V.; Tikhonowski, G. V.; Popov, A. A.; Klimentov, S. M.; Deyev, S. M.; Zavestovskaya, I. N.; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Климентов, Сергей Михайлович; Деев, Сергей Михайлович; Завестовская, Ирина НиколаевнаBoron-enhanced proton therapy has recently appeared as a promising approach to increase the efficiency of proton therapy on tumor cells, and this modality can further be improved by the use of boron nanoparticles (B NPs) as local sensitizers to achieve enhanced and targeted therapeutic outcomes. However, the mechanisms of tumor cell elimination under boron-enhanced proton therapy still require clarification. Here, we explore possible molecular mechanisms responsible for the enhancement of therapeutic outcomes under boron NP-enhanced proton therapy. Spherical B NPs with a mode size of 25 nm were prepared by methods of pulsed laser ablation in water, followed by their coating by polyethylene glycol to improve their colloidal stability in buffers. Then, we assessed the efficiency of B NPs as sensitizers of cancer cell killing under irradiation with a 160.5 MeV proton beam. Our experiments showed that the combined effect of B NPs and proton irradiation induces an increased level of superoxide anion radical generation, which leads to the depolarization of mitochondria, a drop in their membrane mitochondrial potential, and the development of apoptosis. A comprehensive gene expression analysis (via RT-PCR) confirmed increased overexpression of 52 genes (out of 87 studied) involved in the cell redox status and oxidative stress, compared to 12 genes in the cells irradiated without B NPs. Other possible mechanisms responsible for the B NPs-induced radiosensitizing effect, including one related to the generation of alpha particles, are discussed. The obtained results give a better insight into the processes involved in the boron-induced enhancement of proton therapy and enable one to optimize parameters of proton therapy in order to maximize therapeutic outcomes.