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Деев, Сергей Михайлович

Организационные подразделения

Организационная единица

Инженерно-физический институт биомедицины

Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.

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Сергей Михайлович

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Теперь показываю 1 - 10 из 81

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Direct photoacoustic measurement of silicon nanoparticle degradation promoted by a polymer coating
(2022) Mashkovich, E. A.; Deryabin, M. S.; Kurin, V. V.; Bakunov, M. I.; Zelepukin, I. V.; Lipey, N. A.; Popov, A. A.; Shipunova, V. O.; Yu. , Griaznova, O.; Nikitin, P. I.; Kabashin, A. V.; Deyev, S. M.; Zvyagin, A. V.; Попов, Антон Александрович; Грязнова, Ольга Юрьевна; Никитин, Петр Иванович; Кабашин, Андрей Викторович; Деев, Сергей Михайлович
© 2021 Elsevier B.V.Nanomaterials with controllable biodegradation properties respond to the main challenge of cancer nanomedicine to minimise side effects and maximise the delivery efficacy to tumours. These biodegradation properties vary from clear aqueous solutions to protein-abundant biological fluids. A photoacoustic method suitable for in vitro quantification of highly scattering colloids with optical absorption properties is introduced and demonstrated by determination of the degradation rate of laser-synthesized silicon nanoparticles (Si NPs) in turbid serum solutions. In vitro screening of a variety of polymer surface-coatings of Si NPs revealed a stand-alone property of polyallylamine (PAA) to accelerate the Si NP dissolution. PAA-coated Si NP half-life was measured ∼ 100-min in aqueous solutions and slowed down to ∼ 24 h in serum. As-produced PAA-coated Si NPs appeared suitable for blockade of the mononuclear phagocyte system. Pre-treatment with PAA-Si NPs caused 1.4-times reduced uptake of magnetic particles by human THP-1 cells in vitro and a 13-fold increase of the magnetic particle delivery to the B16-F1 xenograft tumours in vivo. The demonstrated photoacoustic method is believed to facilitate design and screening of biodegradable materials suitable for in vivo applications such as controlled drug release.
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Comparison of pharmacokinetics and biodistribution of laser-synthesized plasmonic Au and TiN nanoparticles
(2021) Tselikov, G. I.; Al-Kattan, A.; Bailly, A. -L.; Correard, F.; Popov, A. A.; Zelepukin, I. V.; Tikhonowski, G. V.; Popova-Kuznetsova, E. A.; Klimentov, S. M.; Deyev, S. M.; Kabashin, A. V.; Попов, Антон Александрович; Тихоновский, Глеб Валерьевич; Попова-Кузнецова, Елена Алефтиновна; Климентов, Сергей Михайлович; Деев, Сергей Михайлович; Кабашин, Андрей Викторович
© 2021 Institute of Physics Publishing. All rights reserved.Plasmonic nanostructures offer wide range of diagnostic and therapeutic functionalities for biomedical applications. Gold nanoparticles (Au NPs) present one of the most explored nanomaterial in this field, while titanium nitride nanoparticles (TiN NPs) is a new promising nanomaterial with superior plasmonic properties for biomedicine. However conventional chemical techniques for the synthesis of these nanomaterials cannot always match stringent requirements for toxicity levels and surface conditioning. Laser-synthesized Au and TiN NPs offer exceptional purity (no contamination by by-products or ligands) and unusual surface chemistry. Therefore, these NPs present a viable alternative to chemically synthesized counterparts. This work presents comparative analysis of pharmacokinetics and biodistribution of laser-synthesized 20 nm Au and TiN NPs under intravenous administration in mice model. Our data show that Au NPs and bare TiN NPs are rapidly eliminated from the blood circulation and accumulate preferentially in liver and spleen, while coating of TiN NPs by hydrophilic polymer polyethylene glycol (PEG) significantly prolongates blood circulation time and improves delivery of the NPs to tumor. We finally discuss potential applications of laser synthesized Au NPs in SERS, SEIRA and electrocatalysis, while TiN nanoparticles are considered as promising agents for photothermal therapy and photoacoustic imaging.
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Laser-ablative synthesis of nanomaterials for nuclear and radiative medicine applications
(2022) Tikhonowski, G. V.; Popov, A. A.; Zelepukin, I.; Popova-Kuznetsova, E.; Dombrovska, Y.; Deyev, S. M.; Zavestovskaya, I. N.; Klimentov, S. M.; Prasad, P. N.; Kabashin, A. V.; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Попова-Кузнецова, Елена Алефтиновна; Деев, Сергей Михайлович; Завестовская, Ирина Николаевна; Климентов, Сергей Михайлович; Кабашин, Андрей Викторович
Newly emerging nanomaterials promise a major advancement of methods of nuclear and radiative medicine for cancer treatment, as they can be used as carriers of diagnostic or therapeutic radionuclides, contrast agents in nuclear imaging modalities (PET, SPECT) or sensitizers of radiative therapies (X-ray, ion beams, etc.). However, nanotechnology-based approaches have reported a limited success so far due to a lack of suitable functional nanoformulations, which are safe, non-toxic, excretable from the body and have favorable pharmacokinetics for effective accumulation in the tumor. As follows from the results of our on-going research activities, many of the above-stated problems can we solved by the employment of nanomaterials fabricated by clean laser-ablative synthesis. Here, we review our recent data on some promising nanomaterials, prepared by this method, including biodegradable silicon (Si) nanoparticles (NPs), Sm-152-enriched samarium oxide NPs, and elemental bismuth (Bi) NPs, which can be used either as carriers/agents in radionuclide therapy, or sensitizers in radiative diagnostics or therapy. Advantages of proposed approach include exceptional purity and flexibility in synthesizing of NPs of required physico-chemical parameters (controlled size, shape, composition, and surface conditioning of NPs). Advances in laser-ablative fabrication of novel nanomaterials open up avenues for future implementations of nuclear and radiative medicine approaches for safe and efficient theranostics of tumors and metastasis.
Только метаданные
Fast processes of nanoparticle blood clearance: Comprehensive study
(2020) Yaremenko, A. V.; Yuryev, M. V.; Mirkasymov, A. B.; Sokolov, I. L.; Zelepukin, I. V.; Deyev, S. M.; Nikitin, P. I.; Деев, Сергей Михайлович; Никитин, Петр Иванович
© 2020 Elsevier B.V.Blood circulation is the key parameter that determines the in vivo efficiency of nanoagents. Despite clinical success of the stealth liposomal agents with their inert and shielded surfaces, a great number of non-stealth nanomaterials is being developed due to their potential of enhanced functionality. By harnessing surface phenomena, such agents can offer advanced control over drug release through intricately designed nanopores, catalysis-propelled motion, computer-like analysis of several disease markers for precise target identification, etc. However, investigation of pharmacokinetic behavior of these agents becomes a great challenge due to ultra-short circulation (usually around several minutes) and impossibility to use the invasive blood-sampling techniques. Accordingly, the data on circulation of such agents has been scarce and irregular. Here, we demonstrate high-throughput capabilities of the developed magnetic particle quantification technique for nanoparticle circulation measurements and present a comprehensive investigation of factors that affect blood circulation of the non-stealth nanoparticles. Namely, we studied the following 9 factors: particle size, zeta-potential, coating, injection dose, repetitive administration, induction of anesthesia, mice strain, absence/presence of tumors, tumor size. Our fundamental findings demonstrate potential ways to extend the half-life of the agents in blood thereby giving them a better chance of achieving their goal in the organism. The study will be valuable for design of the next generation nanomaterials with advanced biomedical functionality.
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Bismuth nanoparticles-enhanced proton therapy: Concept and biological assessment
(2024) Zavestovskaya, I. N.; Tikhonowski, G. V.; Savinov, M.; Shakhov, P. V.; Popov, A. A.; Klimentov, S. M.; Deyev, S. M.; Завестовская, Ирина Николаевна; Тихоновский, Глеб Валерьевич; Савинов, Максим Сергеевич; Шахов, Павел Владимирович; Попов, Антон Александрович; Климентов, Сергей Михайлович; Деев, Сергей Михайлович
Только метаданные
Nanoparticle-based drug delivery: Via RBC-hitchhiking for the inhibition of lung metastases growth
(2019) Yaremenko, A. V.; Babenyshev, A. V.; Balalaeva, I. V.; Nikitin, M. P.; Zelepukin, I. V.; Shipunova, V. O.; Nikitin, P. I.; Deyev, S. M.; Никитин, Петр Иванович; Деев, Сергей Михайлович
© The Royal Society of Chemistry. Delivery of particle-based theranostic agents via their transportation on the surfaces of red blood cells, commonly referred to as RBC-hitchhiking, has historically been developed as a promising strategy for increasing the extremely poor blood circulation lifetime, primarily, of the large-sized sub-micron agents. Here, we show for the first time that RBC-hitchhiking can be extremely efficient for nanoparticle delivery and tumor treatment even in those cases when no circulation prolongation is observed. Specifically, we demonstrate that RBC-hitchhiking of certain small 100 nm particles, unlike that of the conventional sub-micron ones, can boost the delivery of non-targeted particles to lungs up to a record high value of 120-fold (and up to 40% of the injected dose). To achieve this remarkable result, we screened sub-200 nm nanoparticles of different sizes, polymer coatings and ζ-potentials and identified particles with the optimal RBC adsorption/desorption behavior. Furthermore, we demonstrated that such RBC-mediated rerouting of particles to lungs can be used to fight pulmonary metastases of aggressive melanoma B16-F1. Our findings could change the general paradigm of drug delivery for cancer treatment with RBC-hitchhiking. It is not the blood circulation lifetime that is the key factor for nanoparticle efficiency, but rather the complexation of nanoparticles with the RBC. The demonstrated technology could become a valuable tool for development of new strategies based on small nanoparticles for the treatment of aggressive and small-cell types of cancer as well as other lung diseases.
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Nanoparticles based on MIL-101 metal-organic frameworks as efficient carriers of therapeutic188Re radionuclide for nuclear medicine
(2024) Belyaev, I. B.; Zelepukin, I. V.; Petriev, V. M.; Klimentov, S. M.; Zavestovskaya, I. N.; Deyev, S. M.; Климентов, Сергей Михайлович; Завестовская, Ирина Николаевна; Деев, Сергей Михайлович
Только метаданные
Polymer-coated BiOCl nanosheets for safe and regioselective gastrointestinal X-ray imaging
(2022) Mirkasymov, A. B.; Shevchenko, K. G.; Kabashin, A. V.; Zelepukin, I. V.; Ivanov, I. N.; Popov, A. A.; Prasad, P. N.; Deyev, S. M.; Попов, Антон Александрович; Деев, Сергей Михайлович
© 2022 Elsevier B.V.Bismuth-based compounds are considered to be the best candidates for computed tomography (CT) imaging of gastrointestinal (GI) tract due to high X-ray absorption. Here, we report the introduction of polymer-coated bismuth oxychloride (BiOCl) nanosheets for highly efficient CT imaging in healthy mice and animal with colitis. We demonstrate simple, low cost and fast aqueous synthesis protocol which provides gram-quantity yield of chemically stable BiOCl nanosheets. The developed contrast gives 2.55-fold better CT enhancement compared to conventional contrast with negligible in vivo toxicity. As a major finding we report a regioselective CT imaging of GI tract by using nanoparticles coated with differentially charged polymers. Coating of nanoparticles with a positively charged polymer leads to their fast accumulation in small intestine, while the coating with negatively charged polymers stimulates prolonged stomach retention. We propose that this effect may be explained by a pH-controlled aggregation of nanoparticles in stomach. This feature may become the basis for advancement in clinical diagnosis of entire GI tract.
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DARPin_9-29-targeted gold nanorods selectively suppress her2-positive tumor growth in mice
(2021) Proshkina, G. M.; Shramova, E. I.; Shilova, M. V.; Ryabova, A. V.; Zelepukin, I. V.; Shipunova, V. O.; Deyev, S. M.; Деев, Сергей Михайлович
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Near-infrared phototherapy has great therapeutic potential for cancer treatment. How-ever, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.
Только метаданные
Imaging of EpCAM expression in pancreatic cancer using radiolabelled DARPin Ec1
(2019) Vorobyeva, A.; Schulga, A.; Abouzayed, A.; Konovalova, E.; Deyev, S. M.; Деев, Сергей Михайлович