Персона: Завестовская, Ирина Николаевна
Загружается...
Email Address
Birth Date
Организационные подразделения
Организационная единица
Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
Статус
Фамилия
Завестовская
Имя
Ирина Николаевна
Имя
72 results
Результаты поиска
Теперь показываю 1 - 10 из 72
- ПубликацияОткрытый доступPulse duration and wavelength effects of laser ablation on the oxidation, hydrolysis, and aging of aluminum nanoparticles in water(2019) Zhang, K.; Ganeev, R. A.; Boltaev, G. S.; Krishnendu, P. S.; Ivanov, D. S.; Zavestovskaya, I. N.; Иванов, Дмитрий Сергеевич; Завестовская, Ирина Николаевна© 2019 by the authors. Licensee MDPI, Basel, Switzerland.We analyzed the formation of the aluminum (Al) nanoparticles (NPs) with triangular shape obtained by ablating Al bulk in liquid using pulses with different durations (5 ns, 200 ps, and 30 fs) and wavelengths (355 nm, 800 nm, and 1064 nm). We report three stages of synthesis and aging of Al NPs: Formation, transformation, and stable stage. The NPs prepared by different pulses are almost identical at the initial stage. The effects of duration and wavelength of the ablation pulses on the aging of NPs are revealed. Pulse duration is determined to be essential for morphological transformation of NPs, while pulse wavelength strongly influences particle sizes. NPs produced by ultra-short pulses have smaller sizes and narrow size distribution. We demonstrate that oxidation and hydrolysis of Al in water are the results of ablation for all pulse durations and wavelengths, which also strongly modify the preferable reaction path of NPs in water, thus affecting the composition and morphology of triangle NPs. The results of modeling of the NPs generation in water due to a 50 ps laser pulse interacting with a thick Al target are presented. Water-based effects in the formation of NPs, their evolution, and solidification are considered from the mechanical and thermophysical points of view. The detailed analysis of the modeling results allowed for determination of the main mechanism responsible for the ablation process followed by the NPs formation.
- ПубликацияОткрытый доступBiological evaluation of histidine and tryptophan labeled with gallium-68 as potential tumor imaging agents(2019) Tishchenko, V. K.; Mikhailovskaya, A. A.; Kuzenkova, K. A.; Kaprin, A. D.; Petriev, V. M.; Zavestovskaya, I. N.; Завестовская, Ирина Николаевна© 2019 Published under licence by IOP Publishing Ltd. Radiolabeled with gallium-68 amino acids can be interesting and promising probes for tumor imaging using positron emission tomography (PET). Radiolabeled amino acids target the increased amino acid transport in cancer cells compared with normal tissues. In this study we labeled two amino acids histidine and tryptophan with 68 Ga, investigated its biodistribution in Wistar rats with subcutaneously transplanted cholangioma RS-1 by gamma counting and compared them with 68 GaCl 3 . The accumulation of 68 Ga-histidine in tumor tissue increased approximately 6 fold from 0.11±0.04 %ID/g at 5 min post injection (p.i.) to 0.67±0.07 %ID/g at 3 h p.i. The amount of 68 Ga-tryptophan in tumor was also risen 2.4 fold from 0.34±0.18 %ID/g to 0.80±0.06 %ID/g at 5 min and 3 h p.i., respectively. In contrast, the uptake of 68 GaCl 3 decreased throughout the study from 0.34±0.07 %ID/g to 0.13±0.04 %ID/g. The uptake and retention of 68 Ga-histidine and 68 Ga-tryptophan in non-target organs, except kidney and femur, were higher than those of 68 GaCl 3 . In conclusion, the obtained results suggest that 68 Ga-histidine and 68 Ga-tryptophan could serve as potential new PET tracers for tumor imaging.
- ПубликацияОткрытый доступEffect of long-wavelength coherent radiation on a biological object (unicellular organism Paramecium Caudatum) in presence of silicon nanoparticles(2019) Oleshenko, V. A.; Karpukhina, O. V.; Alykova, O. M.; Bezotosniy, V. V.; Alykova, A. F.; Karpov, N. V.; Klimentov, S. M.; Timoshenko, V. Y.; Zavestovskaya, I. N.; Климентов, Сергей Михайлович; Тимошенко, Виктор Юрьевич; Завестовская, Ирина Николаевна© 2019 Published under licence by IOP Publishing Ltd. We report an effect of continuous and pulsed near infrared (808 nm) laser radiation on cells (Paramecium Caudatum) incubated with silicon (Si) nanoparticles (NPs), which were obtained by laser ablation of crystalline Si wafer in water. The data obtained indicate the possibility of enhancing the destructive effect on cells by using pulsed laser irradiation and Si NPs.
- ПубликацияОткрытый доступStructurally-dynamic models of substituted benzoic acids(2019) Elkin, M. D.; Smirnov, V. V.; Alykova, O. M.; Stefanova, G. P.; Zavestovskaya, I. N.; Alykova, A. F.; Завестовская, Ирина Николаевна© 2019 Published under licence by IOP Publishing Ltd. On the basis of modelling not empirical quantum calculations of geometrical and electronic structure of some isomers of substituted benzoic acids are investigated regularity in behaviour of parameters of the adiabatic potential a carboxyl fragment.
- ПубликацияОткрытый доступBiodistribution ex vivo of 213 Bi-KHEDP - A promising boneseeking agent for targeted alpha therapy(2019) Tishchenko, V. K.; Stepchenkova, E. D.; Ivanov, S. A.; Kaprin, A. D.; Petriev, V. M.; Zavestovskaya, I. N.; Завестовская, Ирина Николаевна© 2019 Published under licence by IOP Publishing Ltd. Alpha-emitters are increasingly used for targeted alpha therapy because of their emission of high linear energy transfer (LET) particles with a relative short path length. Bismuth-213 ( 213 Bi, T 1/2 = 46 min) is one of the most suitable radiation sources for medical applications. In the present work the biodistribution of 213 Bi-monopotassium salt of 1-hydroxyethylidene diphosphonic acid ( 213 Bi-KHEDP) in intact mice was studied. It was shown that bones uptake of 213 Bi-KHEDP were higher than in the most soft tissue organs throughout the study. The bone-to-soft tissue ratios for 213 Bi-KHEDP were higher than the corresponding data for 213 BiCl 5 . Among the soft tissue organs, only kidneys had a high uptake of Bi-KHEDP and free 213 Bi. In conclusion, 213 Bi-KHEDP had a strong and selective bone affinity, indicating that this complex could be useful to deliver alpha-particle radiation to primary bone cancer and skeletal metastases.
- ПубликацияОткрытый доступBioprotective properties of nano-diamond composition at intragastric introduction to rats(2020) Lomteva, N. A.; Kondratenko, E. I.; Kasimova, S. K.; Gordeev, S. K.; Alykova, A. F.; Zavestovskaya, I. N.; Завестовская, Ирина Николаевна© Published under licence by IOP Publishing Ltd.We studied a biocompatibility and a bioprotector property of nanodiamond composites on reduction of the toxic action to cadmium salt. The experimental animal intragastric received with the help of a probe activated carbon and nanodiamond composite. We researched the rate of spontaneous and ascorbate-dependent lipids peroxidation and the reference level of malonic dialdehyde in liver, thyroid and adrenal glands tissues. So this concentration of the nanopore material at intragastric entering did not led to difference of researched parameters of the lipid peroxidation. The solution of cadmium salt developed typical for it toxic action which expressed in increase intensity of the processes of POL in liver and thyroid gland tissues. The nanopore material developed the characteristic which screened the toxic action of cadmium chloride and it was more denominated on some parameters in comparison with the effect of the intragastric entering of the activated carbon.
- ПубликацияОткрытый доступLocalized infrared radiation-induced hyperthermia sensitized by laser-ablated silicon nanoparticles for phototherapy applications(2020) Oleshchenko, V. A.; Karpukhina, O. V.; Bezotosnyi, V. V.; Kharin, A. Y.; Alykova, A. F.; Karpov, N. V.; Popov, A. A.; Klimentov, S. M.; Zavestovskaya, I. N.; Kabashin, A. V.; Timoshenko, V. Y.; Попов, Антон Александрович; Климентов, Сергей Михайлович; Завестовская, Ирина Николаевна; Кабашин, Андрей Викторович; Тимошенко, Виктор Юрьевич© 2020 Elsevier B.V.Silicon (Si) nanoparticles (NPs) synthesized by methods of laser ablation in water are explored as sensitizers of photothermal therapy under a laser excitation in the window of relative tissue transparency. Based on theoretical calculations and experimental data, it is shown that the NPs can be heated up to temperatures above 42–50 °C by laser diode irradiation at 808 nm in continuous wave (CW) and quasi-continuous wave (QCW) regimes. Profiting from the laser-induced heating, a high efficiency Si-NPs as sensitizers of the hyperthermia of cells in Paramecium Caudatum model is demonstrated. The QCW regime is found to be more efficient, leading to complete cell destruction even under relatively mild laser irradiation conditions. The obtained data evidence a great potential in using laser-ablated Si-NPs as sensitizers of photohyperthermia in antibacterial or cancer therapy applications.
- ПубликацияТолько метаданныеHydroacoustic Pressure Gradient Recording by a System of Two Fiber-Optic Accelerometers(2021) Kamenev, O. T.; Petrov, Y. S.; Podlesnykh, A. A.; Kolchinskiy, V. A.; Zavestovskaya, I. N.; Kulchin, Y. N.; Завестовская, Ирина Николаевна; Кульчин, Юрий Николаевич© 2021, Allerton Press, Inc.Abstract: The paper presents the results of experimental studies of a portable measuring system based on two inertial fiber-optic accelerometers with a multiturn optomechanical transducer placed in a Mach—Zehnder fiber-optic interferometer arm used as a sensitive element. Passive phase demodulation using a fiber-optic splitter 3 × 3 makes it possible to record interferometer output signals in the presence of a thermal drift of the operating point. The possibility of recording using such an acoustic and hydroacoustic pressure gradient system is shown.
- ПубликацияТолько метаданныеProspects for the use of hexagonal ferrite particles for targeted drug delivery and local heating of organic nanocontainers(2021) Rybakov, A. V.; Stepkina, A. P.; Smirnov, V. V.; Alykova, O. M.; Alykova, A. F.; Zavestovskaya, I. N.; Завестовская, Ирина Николаевна© 2021 Institute of Physics Publishing. All rights reserved.Currently, it seems more promising to combine controlled drug delivery using liposomes or other agents in combination with ferrite nanoparticles for the treatment of oncological diseases. The release of drugs can be carried out by heating the particles with an alternating magnetic field. In this case, the local temperature can be set more precisely by selecting the chemical composition and structure of the ferrite in such a way as to obtain the necessary Curie temperature. Moreover, it is possible to concentrate nanoparticles in the desired area with extremely small dimensions using an oriented constant magnetic field. The article analyzes the existing methods of delivering antitumor antibiotics using magnetic nanoparticles, presents its own solutions in the field of magnetic transportation and tracking of nanocontainers, considers the problems of the depth of penetration of the magnetic field into the tissues of the body and minimizing their hyperthermia. The authors proposed to use magnetic particles of hexagonal strontium ferrite synthesized by cryochemical technology for controlled delivery and release by heating.
- ПубликацияТолько метаданныеEffect of silicon target porosity on laser ablation threshold: molecular dynamics simulation(2021) Kharin, A. Y.; Grigoryeva, M. S.; Zavestovskaya, I. N.; Timoshenko, V. Y.; Григорьева, Мария Сергеевна; Завестовская, Ирина Николаевна; Тимошенко, Виктор ЮрьевичAblation of a porous silicon target under irradiation with ultrashort laser pulse is simulated by means of the molecular dynamics approach. The number of ablated atoms is calculated for targets with different porosity under irradiation with wavelengths in ultraviolet (UV) and visible spectral ranges, which correspond to stronger and weaker absorption coefficient, respectively. An increase of the porosity to 80% leads to 1.5-3 times decrease of the ablation threshold compared to the bulk silicon, while a decrease of pores size from 2.5 to 1.2 nm leads to the stronger ablation threshold drop and the effect is stronger for the UV irradiation. The results are useful for laser processing of silicon-based targets and nanofabrication.