Publication: Biological evaluation of histidine and tryptophan labeled with gallium-68 as potential tumor imaging agents
Дата
2019
Авторы
Tishchenko, V. K.
Mikhailovskaya, A. A.
Kuzenkova, K. A.
Kaprin, A. D.
Petriev, V. M.
Zavestovskaya, I. N.
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© 2019 Published under licence by IOP Publishing Ltd. Radiolabeled with gallium-68 amino acids can be interesting and promising probes for tumor imaging using positron emission tomography (PET). Radiolabeled amino acids target the increased amino acid transport in cancer cells compared with normal tissues. In this study we labeled two amino acids histidine and tryptophan with 68 Ga, investigated its biodistribution in Wistar rats with subcutaneously transplanted cholangioma RS-1 by gamma counting and compared them with 68 GaCl 3 . The accumulation of 68 Ga-histidine in tumor tissue increased approximately 6 fold from 0.11±0.04 %ID/g at 5 min post injection (p.i.) to 0.67±0.07 %ID/g at 3 h p.i. The amount of 68 Ga-tryptophan in tumor was also risen 2.4 fold from 0.34±0.18 %ID/g to 0.80±0.06 %ID/g at 5 min and 3 h p.i., respectively. In contrast, the uptake of 68 GaCl 3 decreased throughout the study from 0.34±0.07 %ID/g to 0.13±0.04 %ID/g. The uptake and retention of 68 Ga-histidine and 68 Ga-tryptophan in non-target organs, except kidney and femur, were higher than those of 68 GaCl 3 . In conclusion, the obtained results suggest that 68 Ga-histidine and 68 Ga-tryptophan could serve as potential new PET tracers for tumor imaging.
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Biological evaluation of histidine and tryptophan labeled with gallium-68 as potential tumor imaging agents / Tishchenko, V.K. [et al.] // Journal of Physics: Conference Series. - 2019. - 1189. - № 1. - 10.1088/1742-6596/1189/1/012038