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Biological evaluation of histidine and tryptophan labeled with gallium-68 as potential tumor imaging agents

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dc.contributor.authorTishchenko, V. K.
dc.contributor.authorMikhailovskaya, A. A.
dc.contributor.authorKuzenkova, K. A.
dc.contributor.authorKaprin, A. D.
dc.contributor.authorPetriev, V. M.
dc.contributor.authorZavestovskaya, I. N.
dc.contributor.authorЗавестовская, Ирина Николаевна
dc.date.accessioned2024-11-21T08:28:34Z
dc.date.available2024-11-21T08:28:34Z
dc.date.issued2019
dc.description.abstract© 2019 Published under licence by IOP Publishing Ltd. Radiolabeled with gallium-68 amino acids can be interesting and promising probes for tumor imaging using positron emission tomography (PET). Radiolabeled amino acids target the increased amino acid transport in cancer cells compared with normal tissues. In this study we labeled two amino acids histidine and tryptophan with 68 Ga, investigated its biodistribution in Wistar rats with subcutaneously transplanted cholangioma RS-1 by gamma counting and compared them with 68 GaCl 3 . The accumulation of 68 Ga-histidine in tumor tissue increased approximately 6 fold from 0.11±0.04 %ID/g at 5 min post injection (p.i.) to 0.67±0.07 %ID/g at 3 h p.i. The amount of 68 Ga-tryptophan in tumor was also risen 2.4 fold from 0.34±0.18 %ID/g to 0.80±0.06 %ID/g at 5 min and 3 h p.i., respectively. In contrast, the uptake of 68 GaCl 3 decreased throughout the study from 0.34±0.07 %ID/g to 0.13±0.04 %ID/g. The uptake and retention of 68 Ga-histidine and 68 Ga-tryptophan in non-target organs, except kidney and femur, were higher than those of 68 GaCl 3 . In conclusion, the obtained results suggest that 68 Ga-histidine and 68 Ga-tryptophan could serve as potential new PET tracers for tumor imaging.
dc.identifier.citationBiological evaluation of histidine and tryptophan labeled with gallium-68 as potential tumor imaging agents / Tishchenko, V.K. [et al.] // Journal of Physics: Conference Series. - 2019. - 1189. - № 1. - 10.1088/1742-6596/1189/1/012038
dc.identifier.doi10.1088/1742-6596/1189/1/012038
dc.identifier.urihttps://www.doi.org/10.1088/1742-6596/1189/1/012038
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85065611445&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/17978
dc.relation.ispartofJournal of Physics: Conference Series
dc.titleBiological evaluation of histidine and tryptophan labeled with gallium-68 as potential tumor imaging agents
dc.typeConference Paper
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume1189
relation.isAuthorOfPublication1a1d2a9c-068f-48c6-b18a-7da3ce75cf7a
relation.isAuthorOfPublication.latestForDiscovery1a1d2a9c-068f-48c6-b18a-7da3ce75cf7a
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
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