Publication: Biodistribution ex vivo of 213 Bi-KHEDP - A promising boneseeking agent for targeted alpha therapy
Дата
2019
Авторы
Tishchenko, V. K.
Stepchenkova, E. D.
Ivanov, S. A.
Kaprin, A. D.
Petriev, V. M.
Zavestovskaya, I. N.
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© 2019 Published under licence by IOP Publishing Ltd. Alpha-emitters are increasingly used for targeted alpha therapy because of their emission of high linear energy transfer (LET) particles with a relative short path length. Bismuth-213 ( 213 Bi, T 1/2 = 46 min) is one of the most suitable radiation sources for medical applications. In the present work the biodistribution of 213 Bi-monopotassium salt of 1-hydroxyethylidene diphosphonic acid ( 213 Bi-KHEDP) in intact mice was studied. It was shown that bones uptake of 213 Bi-KHEDP were higher than in the most soft tissue organs throughout the study. The bone-to-soft tissue ratios for 213 Bi-KHEDP were higher than the corresponding data for 213 BiCl 5 . Among the soft tissue organs, only kidneys had a high uptake of Bi-KHEDP and free 213 Bi. In conclusion, 213 Bi-KHEDP had a strong and selective bone affinity, indicating that this complex could be useful to deliver alpha-particle radiation to primary bone cancer and skeletal metastases.
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Biodistribution ex vivo of 213 Bi-KHEDP - A promising boneseeking agent for targeted alpha therapy / Tishchenko, V.K. [et al.] // Journal of Physics: Conference Series. - 2019. - 1189. - № 1. - 10.1088/1742-6596/1189/1/012034