Publication: Prospects for the use of hexagonal ferrite particles for targeted drug delivery and local heating of organic nanocontainers
Дата
2021
Авторы
Rybakov, A. V.
Stepkina, A. P.
Smirnov, V. V.
Alykova, O. M.
Alykova, A. F.
Zavestovskaya, I. N.
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© 2021 Institute of Physics Publishing. All rights reserved.Currently, it seems more promising to combine controlled drug delivery using liposomes or other agents in combination with ferrite nanoparticles for the treatment of oncological diseases. The release of drugs can be carried out by heating the particles with an alternating magnetic field. In this case, the local temperature can be set more precisely by selecting the chemical composition and structure of the ferrite in such a way as to obtain the necessary Curie temperature. Moreover, it is possible to concentrate nanoparticles in the desired area with extremely small dimensions using an oriented constant magnetic field. The article analyzes the existing methods of delivering antitumor antibiotics using magnetic nanoparticles, presents its own solutions in the field of magnetic transportation and tracking of nanocontainers, considers the problems of the depth of penetration of the magnetic field into the tissues of the body and minimizing their hyperthermia. The authors proposed to use magnetic particles of hexagonal strontium ferrite synthesized by cryochemical technology for controlled delivery and release by heating.
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Prospects for the use of hexagonal ferrite particles for targeted drug delivery and local heating of organic nanocontainers / Rybakov, A.V. [et al.] // Journal of Physics: Conference Series. - 2021. - 2058. - № 1. - 10.1088/1742-6596/2058/1/012017