Персона: Завестовская, Ирина Николаевна
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Ирина Николаевна
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- ПубликацияТолько метаданныеEffect of Spatial Dispersion on Plasmon Resonance in Silver Nanoparticles(2019) Wriedt, T.; Lopushenko, I. V.; Zavestovskaya, I. N.; Завестовская, Ирина Николаевна© 2019, Allerton Press, Inc.Using the modified discrete sources method, the problem of calculating plasmon spectra of the characteristic energy loss of electrons during the interaction with silver nanoparticles from 2 to 8 nm in size is solved. The calculated spectra are compared with the experimental data confirming the significant spatial dispersion effect. The importance of the consideration of this factor when analyzing the properties of plasmonic nanoparticles for applications in biosensorics and biomedicine is discussed.
- ПубликацияТолько метаданныеHigh-throughput laser generation of Si-nanoparticle based surface coatings for antibacterial applications(2019) Nastulyavichus, A. A.; Smirnov, N. A.; Khmelnitskiy, R. A.; Rudenko, A. A.; Kudryashov, S. I.; Ivanova, A. K.; Yu. , Kharin, A.; Zavestovskaya, I. N.; Завестовская, Ирина Николаевна© 2018 Elsevier B.V. High-productivity regime of nanosecond IR-laser ablative generation of silicon colloidal solutions in water for anti-bacterial applications was found in terms of GW/cm2-level laser intensity and scanning velocity by measuring multi-shot ablative mass loss and extinction coefficients of the colloids as sub-linear and third-power intensity functions, respectively. This advantageous regime implies sub-linear mass loss versus laser intensity at the simultaneous third-power yield of nanoparticles, resulting from the subcritical-density, opaque ablative plasma regulating the sample ablation rate and the related plasma-mediated dissociation (dispergation) of the ablation products. In contrast, at higher intensities, there is a drastic increase in mass loss with the corresponding increased yield of (sub) micrometer-sized particles owing to intense plasma-driven expulsion of micro-scale melt droplets and the corresponding saturation of the extinction coefficient of the colloidal solutions because of their dynamic local “self-limiting” effect during the high-rate ablation. The optimal low-intensity regime for Si nanoparticle production demonstrates the monotonous correlated increase of mass loss and extinction coefficient in terms of increasing laser scanning velocity, indicating the diminished cumulative effects. Surface coatings prepared from the generated Si nanoparticles exhibit minor surface oxidation, as acquired as their elemental composition via energy-dispersive X-ray spectroscopy, making their contact angle for water droplets (≈51°) close to that of bare Si wafer (≈58°) with its nanometer-thick native oxide layer. Owing to good wetting, the nanoparticle-based surface coatings show strong antibacterial response regarding Gram-negative Pseudomonas auereginosa bacteria even despite their minor oxidative passivation.
- ПубликацияТолько метаданныеBi-Modal Nonlinear Optical Contrast from Si Nanoparticles for Cancer Theranostics(2019) Rogov, A.; Ryabchikov, Y. V.; Geloen, A.; Tishchenko, I.; Kharin, A. Y.; Lysenko, V.; Zavestovskaya, I. N.; Kabashin, A. V.; Timoshenko, V. Y.; Завестовская, Ирина Николаевна; Кабашин, Андрей Викторович; Тимошенко, Виктор Юрьевич© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Presenting a safe alternative to conventional compound quantum dots and other functional nanostructures, nanosilicon can offer a series of breakthrough hyperthermia-based therapies under near-infrared, radiofrequency, ultrasound, etc., excitation, but the size range to sensitize these therapies is typically too large (>10 nm) to enable efficient imaging functionality based on photoluminescence properties of quantum-confined excitonic states. Here, it is shown that large Si nanoparticles (NPs) are capable of providing two-photon excited luminescence (TPEL) and second harmonic generation (SHG) responses, much exceeding that of smaller Si NPs, which promises their use as probes for bi-modal nonlinear optical bioimaging. It is finally demonstrated that the combination of TPEL and SHG channels makes possible efficient tracing of both separated Si NPs and their aggregations in different cell compartments, while the resolution of such an approach is enough to obtain 3D images. The obtained bi-modal contrast provides lacking imaging functionality for large Si NPs and promises the development of novel cancer theranostic modalities on their basis.
- ПубликацияТолько метаданныеComplex Compounds of Rhenium-188 and Gallium-68 Radionuclides and Their Behavior in the Organism of Laboratory Animals(2019) Petriev, V. M.; Tishchenko, V. K.; Smoryzanova, O. A.; Zavestovskaya, I. N.; Postnov, A. A.; Завестовская, Ирина Николаевна© 2019, Allerton Press, Inc.This paper concerns the study of pharmacokinetic properties of rhenium-188 and gallium-68 bound to a ligand based on tetraphosphonic acid (188 Re,68 Ga-EDTMP). The pharmacokinetics of 188 Re,68 Ga-EDTMP is studied using outbred rats after intravenous injection of the preparation; the results are compared with the properties of 188 Re-EDTMP and 68 Ga-EDTMP. Rapid and selective activity accumulation in bone tissue is observed. The peak specific contents of 68 Ga and 188 Re in the femoral bone are 6.85%/g and 2.76%/g, respectively. Throughout the study, the activity of radionuclides in bone tissue was higher than in blood and most soft tissue organs. 188 Re,68 Ga-EDTMP was excreted via the urinary tract. Increased activity is recorded in the thyroid gland. Other organs and tissues are characterized by low contents of the preparation. After intravenous injection of 188 Re-EDTMP and 68 Ga-EDTMP, the activity of 188 Re and 68 Ga is lower in comparison with 188 Re,68 Ga-EDTMP. Thus,188 Re,68 Ga-EDTMP is a promising preparation for theranostics of bone metastases.
- ПубликацияТолько метаданныеLaser-Processed Nanosilicon: A Multifunctional Nanomaterial for Energy and Healthcare(2019) Singh, A.; Swihart, M. T.; Kabashin, A. V.; Zavestovskaya, I. N.; Prasad, P. N.; Кабашин, Андрей Викторович; Завестовская, Ирина НиколаевнаCopyright © 2019 American Chemical Society.This review describes promising laser-based approaches to produce silicon nanostructures, including laser ablation of solid Si targets in residual gases and liquids and laser pyrolysis of silane. These methods are different from, and complementary to, widely used porous silicon technology and alternative synthesis routes. One can use these methods to make stable colloidal dispersions of silicon nanoparticles in both organic and aqueous media, which are suitable for a multitude of applications across the important fields of energy and healthcare. Size tailoring allows production of Si quantum dots with efficient photoluminescence that can be tuned across a broad spectral range from the visible to near-IR by varying particle size and surface functionalization. These nanoparticles can also be integrated with other nanomaterials to make multifunctional composites incorporating magnetic and/or plasmonic components. In the energy domain, this review highlights applications to photovoltaics and photodetectors, nanostructured silicon anodes for lithium ion batteries, and hydrogen generation from water. Application to nanobiophotonics and nanomedicine profits from the excellent biocompatibility and biodegradability of nanosilicon. These applications encompass several types of bioimaging and various therapies, including photodynamic therapy, RF thermal therapy, and radiotherapy. The review concludes with a discussion of challenges and opportunities in the applications of laser-processed nanosilicon.
- ПубликацияТолько метаданныеAnxiolytic and mnemotropic effects of herbal extracts in an experiment on laboratory animals(2019) Lomteva, N. A.; Kondratenko, E. I.; Kasimova, S. K.; Alykova, O. M.; Zavestovskaya, I. N.; Alykova, A. F.; Завестовская, Ирина Николаевна© 2019 Published under licence by IOP Publishing Ltd. We research memory, exploratory behavior and anxiety in adult rats in an experiment. These parameters were assessed through the use of behavioral assays, namely, the Suok test and passive avoidance learning. These parameters were studied after treatment with extracts of Ginkgo Biloba and salvia. The aqueous extract of salvia and Ginkgo-Biloba contributed to the activation of patterns of exploratory behavior and a decrease of anxiety in animals in the Suok-test. The Ginkgo-Biloba extract stimulates cognitive functions in rats, which is reflected in an improvement in the elaboration of the conditioned reflex and the preservation of the memorable trace after training in the passive avoidance learning.
- ПубликацияТолько метаданныеEffect of Gallium Carrier in Ga-68-Ethylenediaminetetrakis (Methylene Phosphonic Acid) on its Behavior in Laboratory Animals(2019) Petriev, V. M.; Tishchenko, V. K.; Stepchenkova, E. D.; Zavestovskaya, I. N.; Завестовская, Ирина НиколаевнаThis paper concerns the study of the effect of the stable gallium carrier and its concentration on the biodistribution of a new osteotropic compound based on N,N,N ' N '-ethylenediaminetetrakis (methylene phosphonic acid) and gallium-68 (Ga-68-EDTMP). The studies are performed on intact Wistar rats. It is shown that the bone tissue activity increases as the carrier is added, whereas it decreases in internals and tissues. The carrier concentration has no significant effect on the Ga-68-EDTMP.
- ПубликацияТолько метаданныеNon-Stationary Photovoltage in Materials Science of Wide Band-Gap Semiconductors of Modern Adaptive Optics and Optoelectronics(2019) Bryushinin, M. A.; Sokolov, I. A.; Romashko, R. V.; Zavestovskaya, I. N.; Kul'chin, Y. N.; Завестовская, Ирина Николаевна; Кульчин, Юрий Николаевич© 2019, Allerton Press, Inc.Non-stationary photovoltage excitation in silicon carbide and gallium oxide crystals is studied. The signal transient responses are measured, and the photoelectric parameters necessary for developing adaptive photodetectors, i.e., the specific photoconductivity, Maxwell relaxation time, and diffusion length of carrier transport, are determined. The sensitivity of the photodetector based on gallium oxide is determined.
- ПубликацияТолько метаданныеReflectance Modification in Nanostructured Silicon Layers with Gradient Porosity(2019) Mussabek, G. K.; Yermukhamed, D.; Suleimenova, Z. A.; Assilbayeva, R. B.; Zavestovskaya, I. N.; Timoshenko, V. Y.; Завестовская, Ирина Николаевна; Тимошенко, Виктор ЮрьевичA significant change in effective reflectance spectra of nanostructured porous silicon layers grown with different times of metal-assisted chemical etching is detected. The low reflectances at the level of 5-10% measured in the spectral range of 200-400 nm are explained by strong elastic scattering of light in combination with absorption in silicon nanostructures, while a reflectance increase in the range of 500-1800 nm, which is visually detected as a "white" layer appearance is associated with Mie scattering in silicon nanostructures with gradient porosity under conditions of weak optical absorption. The results obtained are discussed from the viewpoint of potential applications of "black" and "white" nanocrystalline silicon in photonics and sensorics.