Publication:
Complex Compounds of Rhenium-188 and Gallium-68 Radionuclides and Their Behavior in the Organism of Laboratory Animals

Дата
2019
Авторы
Petriev, V. M.
Tishchenko, V. K.
Smoryzanova, O. A.
Zavestovskaya, I. N.
Postnov, A. A.
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Научные группы
Организационные подразделения
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Организационная единица
Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Аннотация
© 2019, Allerton Press, Inc.This paper concerns the study of pharmacokinetic properties of rhenium-188 and gallium-68 bound to a ligand based on tetraphosphonic acid (188 Re,68 Ga-EDTMP). The pharmacokinetics of 188 Re,68 Ga-EDTMP is studied using outbred rats after intravenous injection of the preparation; the results are compared with the properties of 188 Re-EDTMP and 68 Ga-EDTMP. Rapid and selective activity accumulation in bone tissue is observed. The peak specific contents of 68 Ga and 188 Re in the femoral bone are 6.85%/g and 2.76%/g, respectively. Throughout the study, the activity of radionuclides in bone tissue was higher than in blood and most soft tissue organs. 188 Re,68 Ga-EDTMP was excreted via the urinary tract. Increased activity is recorded in the thyroid gland. Other organs and tissues are characterized by low contents of the preparation. After intravenous injection of 188 Re-EDTMP and 68 Ga-EDTMP, the activity of 188 Re and 68 Ga is lower in comparison with 188 Re,68 Ga-EDTMP. Thus,188 Re,68 Ga-EDTMP is a promising preparation for theranostics of bone metastases.
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Complex Compounds of Rhenium-188 and Gallium-68 Radionuclides and Their Behavior in the Organism of Laboratory Animals / Petriev, V.M. [et al.] // Bulletin of the Lebedev Physics Institute. - 2019. - 46. - № 2. - P. 58-64. - 10.3103/S1068335619020052
URI
https://www.doi.org/10.3103/S1068335619020052
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85066477956&origin=resultslist
 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000469859800005
 https://openrepository.mephi.ru/handle/123456789/18181
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