Publication:
Radiation-induced transgenerational effects in animals

Дата
2022
Авторы
Dubrova, Y. E.
Sarapultseva, E. I.
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Издатель
Научные группы
Организационные подразделения
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Организационная единица
Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
Выпуск журнала
Аннотация
© Copyright © 2020 Taylor and Francis Group LLC.According to the results of recent studies, parental exposure to ionizing radiation not only leads to mutation induction in the germline of irradiated animals but also affects their non-exposed offspring. These radiation-induced transgenerational effects belong to an epigenetic phenomenon that could not be defined as a transmission of altered phenotypes from the irradiated parents to their non-exposed offspring. In this review, we present the results of laboratory studies aimed to evaluate the transgenerational effects of parental irradiation on a number of traits in the offspring of exposed parents. The results of animal studies showing compromised viability, fertility and genome stability among the non-exposed offspring of irradiated parents are presented and discussed. So far, the epigenetic phenomenon of radiation-induced transgenerational effects has been established in laboratory studies. Future work should address the important issue of manifestation of radiation-induced transgenerational effects in populations inhabiting radioactive-contaminated areas, as well as the mechanisms of transgenerational effects.
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Цитирование
Dubrova, Y. E. Radiation-induced transgenerational effects in animals / Dubrova, Y.E., Sarapultseva, E.I. // International Journal of Radiation Biology. - 2022. - 10.1080/09553002.2020.1793027
URI
https://www.doi.org/10.1080/09553002.2020.1793027
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85088995338&origin=resultslist
 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000555261200001
 https://openrepository.mephi.ru/handle/123456789/28555
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