Publication: Biological behavior of a new 68Ga-labelled glucose derivative as a potential agent for tumor imaging
Дата
2021
Авторы
Tishchenko, V. K.
Kuzenkova, K. A.
Shegai, P. V.
Ivanov, S. A.
Petriev, V. M.
Zavestovskaya, I. N.
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© 2021 Institute of Physics Publishing. All rights reserved.Glucose analogs and derivatives labeled with positron emitter 68Ga are considered to be a promising alternative to widely used radiotracer 18F-FDG for tumor PET imaging. In this study a biodistribution of a new glucose derivative labeled with 68Ga (68Ga-NODA-thioglucose) was investigated. All biodistribution studies were carried out in Balb/c mice with experimental model of tumor or aseptic inflammation. The tumor uptake of 68Ga-NODA-TG decreased throughout the study from 3.00±0.08 % ID/g to 1.06±0.04 %ID/g. The peak amount of 68Ga-NODA-TG in muscle with inflammation reached 4.33±0.12 % ID/g, decreasing to 0.23±0.08 % ID/g. In other organs and tissues the biodistribution of 68Ga-NODA-TG was similar in tumor-bearing mice and mice with aseptic inflammation. In conclusion, the obtained results suggest that 68Ga-NODA-TG has the potential for clinical application as a PET tracer.
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Biological behavior of a new 68Ga-labelled glucose derivative as a potential agent for tumor imaging / Tishchenko, V.K. [et al.] // Journal of Physics: Conference Series. - 2021. - 2058. - № 1. - 10.1088/1742-6596/2058/1/012037