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Biological behavior of a new 68Ga-labelled glucose derivative as a potential agent for tumor imaging

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dc.contributor.authorTishchenko, V. K.
dc.contributor.authorKuzenkova, K. A.
dc.contributor.authorShegai, P. V.
dc.contributor.authorIvanov, S. A.
dc.contributor.authorPetriev, V. M.
dc.contributor.authorZavestovskaya, I. N.
dc.contributor.authorЗавестовская, Ирина Николаевна
dc.date.accessioned2024-11-29T23:19:07Z
dc.date.available2024-11-29T23:19:07Z
dc.date.issued2021
dc.description.abstract© 2021 Institute of Physics Publishing. All rights reserved.Glucose analogs and derivatives labeled with positron emitter 68Ga are considered to be a promising alternative to widely used radiotracer 18F-FDG for tumor PET imaging. In this study a biodistribution of a new glucose derivative labeled with 68Ga (68Ga-NODA-thioglucose) was investigated. All biodistribution studies were carried out in Balb/c mice with experimental model of tumor or aseptic inflammation. The tumor uptake of 68Ga-NODA-TG decreased throughout the study from 3.00±0.08 % ID/g to 1.06±0.04 %ID/g. The peak amount of 68Ga-NODA-TG in muscle with inflammation reached 4.33±0.12 % ID/g, decreasing to 0.23±0.08 % ID/g. In other organs and tissues the biodistribution of 68Ga-NODA-TG was similar in tumor-bearing mice and mice with aseptic inflammation. In conclusion, the obtained results suggest that 68Ga-NODA-TG has the potential for clinical application as a PET tracer.
dc.identifier.citationBiological behavior of a new 68Ga-labelled glucose derivative as a potential agent for tumor imaging / Tishchenko, V.K. [et al.] // Journal of Physics: Conference Series. - 2021. - 2058. - № 1. - 10.1088/1742-6596/2058/1/012037
dc.identifier.doi10.1088/1742-6596/2058/1/012037
dc.identifier.urihttps://www.doi.org/10.1088/1742-6596/2058/1/012037
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85119521124&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/24979
dc.relation.ispartofJournal of Physics: Conference Series
dc.titleBiological behavior of a new 68Ga-labelled glucose derivative as a potential agent for tumor imaging
dc.typeConference Paper
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume2058
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relation.isAuthorOfPublication.latestForDiscovery1a1d2a9c-068f-48c6-b18a-7da3ce75cf7a
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