Publication:
Laser-ablative synthesis of isotope-enriched samarium oxide nanoparticles for nuclear nanomedicine

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W2997989182.pdf(2.22 MB)
Дата
2020
Авторы
Duflot, V.
Popova-Kuznetsova, E.
Tikhonowski, G.
Popov, A. A.
Deyev, S.
Klimentov, S.
Zavestovskaya, I.
Prasad, P. N.
Kabashin, A. V.
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Организационные подразделения
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Аннотация
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.Nuclear nanomedicine is an emerging field, which utilizes nanoformulations of nuclear agents to increase their local concentration at targeted sites for a more effective nuclear therapy at a considerably reduced radiation dosage. This field needs the development of methods for controlled fabrication of nuclear agents carrying nanoparticles with low polydispersity and with high colloidal stability in aqueous dispersions. In this paper, we apply methods of femtosecond (fs) laser ablation in deionized water to fabricate stable aqueous dispersion of152Sm-enriched samarium oxide nanoparticles (NPs), which can capture neutrons to become153Sm beta-emitters for nuclear therapy. We show that direct ablation of a152Sm-enriched samarium oxide target leads to widely size-and shape-dispersed populations of NPs with low colloidal stability. However, by applying a second fs laser fragmentation step to the dispersion of initially formed colloids, we achieve full homogenization of NPs size characteristics, while keeping the same composition. We also demonstrate the possibility for wide-range tuning of the mean size of Sm-based NPs by varying laser energy during the ablation or fragmentation step. The final product presents dispersed solutions of samarium oxide NPs with relatively narrow size distribution, having spherical shape, a controlled mean size between 7 and 70 nm and high colloidal stability. The formed NPs can also be of importance for catalytic and biomedical applications.
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Laser-ablative synthesis of isotope-enriched samarium oxide nanoparticles for nuclear nanomedicine / Duflot, V. [et al.] // Nanomaterials. - 2020. - 10. - № 1. - 10.3390/nano10010069
URI
https://www.doi.org/10.3390/nano10010069
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85077587366&origin=resultslist
 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000516825600069
 https://openrepository.mephi.ru/handle/123456789/20133
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