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Laser-ablative synthesis of isotope-enriched samarium oxide nanoparticles for nuclear nanomedicine

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dc.contributor.authorDuflot, V.
dc.contributor.authorPopova-Kuznetsova, E.
dc.contributor.authorTikhonowski, G.
dc.contributor.authorPopov, A. A.
dc.contributor.authorDeyev, S.
dc.contributor.authorKlimentov, S.
dc.contributor.authorZavestovskaya, I.
dc.contributor.authorPrasad, P. N.
dc.contributor.authorKabashin, A. V.
dc.contributor.authorПопова-Кузнецова, Елена Алефтиновна
dc.contributor.authorТихоновский, Глеб Валерьевич
dc.contributor.authorПопов, Антон Александрович
dc.contributor.authorДеев, Сергей Михайлович
dc.contributor.authorКлиментов, Сергей Михайлович
dc.contributor.authorЗавестовская, Ирина Николаевна
dc.contributor.authorКабашин, Андрей Викторович
dc.date.accessioned2024-11-25T15:33:29Z
dc.date.available2024-11-25T15:33:29Z
dc.date.issued2020
dc.description.abstract© 2019 by the authors. Licensee MDPI, Basel, Switzerland.Nuclear nanomedicine is an emerging field, which utilizes nanoformulations of nuclear agents to increase their local concentration at targeted sites for a more effective nuclear therapy at a considerably reduced radiation dosage. This field needs the development of methods for controlled fabrication of nuclear agents carrying nanoparticles with low polydispersity and with high colloidal stability in aqueous dispersions. In this paper, we apply methods of femtosecond (fs) laser ablation in deionized water to fabricate stable aqueous dispersion of152Sm-enriched samarium oxide nanoparticles (NPs), which can capture neutrons to become153Sm beta-emitters for nuclear therapy. We show that direct ablation of a152Sm-enriched samarium oxide target leads to widely size-and shape-dispersed populations of NPs with low colloidal stability. However, by applying a second fs laser fragmentation step to the dispersion of initially formed colloids, we achieve full homogenization of NPs size characteristics, while keeping the same composition. We also demonstrate the possibility for wide-range tuning of the mean size of Sm-based NPs by varying laser energy during the ablation or fragmentation step. The final product presents dispersed solutions of samarium oxide NPs with relatively narrow size distribution, having spherical shape, a controlled mean size between 7 and 70 nm and high colloidal stability. The formed NPs can also be of importance for catalytic and biomedical applications.
dc.identifier.citationLaser-ablative synthesis of isotope-enriched samarium oxide nanoparticles for nuclear nanomedicine / Duflot, V. [et al.] // Nanomaterials. - 2020. - 10. - № 1. - 10.3390/nano10010069
dc.identifier.doi10.3390/nano10010069
dc.identifier.urihttps://www.doi.org/10.3390/nano10010069
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85077587366&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000516825600069
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/20133
dc.relation.ispartofNanomaterials
dc.titleLaser-ablative synthesis of isotope-enriched samarium oxide nanoparticles for nuclear nanomedicine
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume10
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