Publication: Antitumor activity of aminochromene derivative on the human-derived lung adenocarcinoma xenograft model in BALB/C nu/nu mice IÐIOEAIIIOOIEAAIA AAENOAEA IÐIECAIAIIAI AIEIIOÐIIAIA IA IIAAEE ENAIIAÐAOOA AAAIIEAÐOEIIIU EAAEIAI O IUØAE nu/nu BALB
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2021
Авторы
Dudina, M. O.
Blinov, D. S.
Suslova, I. R.
Skachilova, S. Ya.
Blinova, E. V.
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© 2021 Izdatel'stvo Meditsina. All rights reserved.The antitumor and anti-metastatic effects of aminochromene derivative AKh-554 upon intragastric administration were studied on immunodeficient BALB/c nu/nu female mice with heterotopic human-derived lung adenocarcinoma xenograft model. In the tumor tissue of animals treated with the test compound, the levels of TUBB3, ALK and c-MET/HFG oncomarkers were quantitatively detected and it was found that the drug suppressed the velocity of tumor growth and its size as well as exhibited anti-metastatic activity. AKh-554 produced 3.3-fold increase in tumor carriers survival and induced stable remission in 60% of test mice (p 0.001). The effect might be due to anti-ALK-dependent activation of apoptosis of tumor cells and suppression of cell proliferation. The results were obtained on the tumor system without signs of pharmacoresistance to AX-554, which was confirmed by the lack of dynamics of c-MET/HFG in tumor tissue in all test groups.
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Antitumor activity of aminochromene derivative on the human-derived lung adenocarcinoma xenograft model in BALB/C nu/nu mice IÐIOEAIIIOOIEAAIA AAENOAEA IÐIECAIAIIAI AIEIIOÐIIAIA IA IIAAEE ENAIIAÐAOOA AAAIIEAÐOEIIIU EAAEIAI O IUØAE nu/nu BALB / Dudina, M.O. [et al.] // Eksperimental'naya i Klinicheskaya Farmakologiya. - 2021. - 84. - № 6. - P. 35-39. - 10.30906/0869-2092-2021-84-6-35-39