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Antitumor activity of aminochromene derivative on the human-derived lung adenocarcinoma xenograft model in BALB/C nu/nu mice IÐIOEAIIIOOIEAAIA AAENOAEA IÐIECAIAIIAI AIEIIOÐIIAIA IA IIAAEE ENAIIAÐAOOA AAAIIEAÐOEIIIU EAAEIAI O IUØAE nu/nu BALB

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dc.contributor.authorDudina, M. O.
dc.contributor.authorBlinov, D. S.
dc.contributor.authorSuslova, I. R.
dc.contributor.authorSkachilova, S. Ya.
dc.contributor.authorBlinova, E. V.
dc.contributor.authorБлинова, Екатерина Валериевна
dc.date.accessioned2024-11-29T18:47:04Z
dc.date.available2024-11-29T18:47:04Z
dc.date.issued2021
dc.description.abstract© 2021 Izdatel'stvo Meditsina. All rights reserved.The antitumor and anti-metastatic effects of aminochromene derivative AKh-554 upon intragastric administration were studied on immunodeficient BALB/c nu/nu female mice with heterotopic human-derived lung adenocarcinoma xenograft model. In the tumor tissue of animals treated with the test compound, the levels of TUBB3, ALK and c-MET/HFG oncomarkers were quantitatively detected and it was found that the drug suppressed the velocity of tumor growth and its size as well as exhibited anti-metastatic activity. AKh-554 produced 3.3-fold increase in tumor carriers survival and induced stable remission in 60% of test mice (p 0.001). The effect might be due to anti-ALK-dependent activation of apoptosis of tumor cells and suppression of cell proliferation. The results were obtained on the tumor system without signs of pharmacoresistance to AX-554, which was confirmed by the lack of dynamics of c-MET/HFG in tumor tissue in all test groups.
dc.format.extentС. 35-39
dc.identifier.citationAntitumor activity of aminochromene derivative on the human-derived lung adenocarcinoma xenograft model in BALB/C nu/nu mice IÐIOEAIIIOOIEAAIA AAENOAEA IÐIECAIAIIAI AIEIIOÐIIAIA IA IIAAEE ENAIIAÐAOOA AAAIIEAÐOEIIIU EAAEIAI O IUØAE nu/nu BALB / Dudina, M.O. [et al.] // Eksperimental'naya i Klinicheskaya Farmakologiya. - 2021. - 84. - № 6. - P. 35-39. - 10.30906/0869-2092-2021-84-6-35-39
dc.identifier.doi10.30906/0869-2092-2021-84-6-35-39
dc.identifier.urihttps://www.doi.org/10.30906/0869-2092-2021-84-6-35-39
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85112025262&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/24501
dc.relation.ispartofEksperimental'naya i Klinicheskaya Farmakologiya
dc.titleAntitumor activity of aminochromene derivative on the human-derived lung adenocarcinoma xenograft model in BALB/C nu/nu mice IÐIOEAIIIOOIEAAIA AAENOAEA IÐIECAIAIIAI AIEIIOÐIIAIA IA IIAAEE ENAIIAÐAOOA AAAIIEAÐOEIIIU EAAEIAI O IUØAE nu/nu BALB
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue6
oaire.citation.volume84
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relation.isAuthorOfPublication.latestForDiscovery0c031abf-8253-47f2-8d12-e505ecc35bb3
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