Персона:
Блинова, Екатерина Валериевна

Научные группы

Научная группа

Организационные подразделения

Организационная единица

Инженерно-физический институт биомедицины

Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.

Фамилия

Блинова

Имя

Екатерина Валериевна

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Теперь показываю 1 - 10 из 20

Только метаданные
Expression of p53 protein associates with anti-pd-l1 treatment response on human-derived xenograft model of gata3/cr5/6-negative recurrent nonmuscular invasive bladder urothelial carcinoma
(2021) Samishina, E.; Deryabina, O.; Blinov, D.; Roshchin, D.; Blinova, E.; Блинова, Екатерина Валериевна
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Background: The possible involvement of p53 signaling, FGFR3 expression, and FGFR3 mutation rates in the prediction of the NMIBC anti-PD-L1 treatment response needs to be clarified. The main aim of our study was to explore predictive value of p53 expression, FGFR3 expression, and its gene mutation status for the therapeutic success of anti-PD-L1 treatment in the patient-derived murine model of recurrent high-PD-L1(+) GATA3(-)/CR5/6(-) high-grade and low-grade NMIBC. Methods: twenty lines of patient-derived xenografts (PDXs) of relapsed high-PD-L1(+) double-negative NMIBC were developed, of which 10 lines represented high-grade tumors and the other ones—low-grade bladder cancer. Acceptors of each grade-related branch received specific anti-PD-L1 antibodies. Animals’ survival, tumor-doubling time, and remote metastasis were followed during the post-interventional period. PD-L1, GATA3, CR5/6, and p53 protein expressions in engrafted tumors were assessed by immunohistochemistry. The FGFR3 expression and FGFR3 mutations in codons 248 and 249 were detected by real-time polymerase chain reaction. Results: The expression of p53 protein is an independent factor affecting the animals’ survival time [HR = 0.036, p = 0.031] of anti-PD-L1-treated mice with low-grade high-PD-L1(+) double-negative NMIBC PDX. The FGFR3 expression and FGFR3 mutation rate have no impact on the anti-PD-L1 treatment response in the interventional groups. Conclusions: p53 expression may be considered as a prognostic factor for the anti-PD-L1 treatment efficacy of low-grade high-PD-L1-positive GATA3(-)/CR5/6(-)relapsed noninvasive bladder cancer.
Только метаданные
Synthesis and In Silico Prediction of the Molecular-Targeting Anti-EGFR Action of a Novel Dihydroacridinone
(2024) Epishkina, A. A.; Bogoslovskaya, E. V.; Pakina, V. A.; Blinova, E. V.; Епишкина, Анна Алексеевна; Блинова, Екатерина Валериевна
Открытый доступ
Clinical Anatomy of the Ligaments of the Face and Their Fundamental Distinguishing Features
(2024) Mirontsev, A.; Andruschenko, O.; Vasil’ev, Y.; Blinova, E.; Миронцев, Артём Владимирович; Блинова, Екатерина Валериевна
Our study aimed to clarify the anatomical features of the zygomatic, upper masseteric, lower masseteric and mandibular ligaments and their possible contribution to age-related gravitational ptosis. The study was carried out by the method of layered dissection of fresh cadavers. In several observations, the zygomatic ligament is represented by the fibers originating from the zygomaticus major muscle fibers. It is a true ligament with the fibers inserted directly into the skin. The upper and lower masseteric ligaments originate from the parotideomasseteric fascia and weave into the thickness of the SMAS. The mandibular ligament consists of two connective tissue laminae originating from the parotideomasseteric fascia at the lower edge of the mandible and from the inner surface of this fascia, along the anterior edge of the masseter muscle, skirting the facial vein sheath and the facial artery, traveling toward the platysma and the depressor anguli oris muscle, and merging with their fibers. The zygomatic ligament should be considered an osteo-musculocutaneous ligament, emphasizing the role of the associated zygomaticus major muscle in the mechanism of aging. The upper and lower masseteric and mandibular ligaments are false fascio-SMAS ligaments rather than osteo-cutaneous ones, playing the barrier role and fixing the superficial fascia and the platysma muscle.
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Effects of Satureja montana L. and Origanum vulgare L. Hydrolates in Rabbit Burn Wound Model: Evaluation of Inflammatory, Antioxidant Activity, and Pro-Regenerative Properties in the Skin
(2025) Demyashkin, G.; Tokov, A.; Belokopytov, D.; Shchekin, V.; Blinova, E. ..; Блинова, Екатерина Валериевна
Только метаданные
Clinical and experimental rationale for using phenylephrine with hypromellose for the treatment of extra accommodation strain in patients with myopia
(2023) Makhova, M. V.; Shikh, E. V.; Strakhov, V. V.; Blinova, E. V.; Blinov, D. S.; Блинова, Екатерина Валериевна
Только метаданные
THREE-DIMENSIONAL ORGANOID MODEL OF PEDIATRIC GLIOMAS FOR THE EVALUATION OF DRUG SENSITIVITY ТРЕХМЕРНАЯ ОРГАНОИДНАЯ МОДЕЛЬ ДЕТСКИХ ГЛИОМ ДЛЯ ОЦЕНКИ ЛЕКАРСТВЕННОИ ЧУВСТВИТЕЛЬНОСТИ ОПУХОЛИ
(2026) Osipyants, A. I.; Kocharyan, L. S.; Lunyov, I. V.; Filkova, A. A.; Blinova, E. V.; Madyarov, Zh. M.; Sulimanov, M. A.; Осипьянц, Андрей Игоревич; Лунёв, Игорь Вячеславович; Филькова, Александра Андреевна; Блинова, Екатерина Валериевна
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Clinical anatomy features of the buccal part of the facial vein Особенности клиническои анатомии лицевои вены в щечнои области
(2023) Mirontsev, A. V.; Vasil’ev, Yu. L.; Kolesova, L. Yu.; Zhandarov, K. A.; Blinova, E. V.; Миронцев, Артём Владимирович; Блинова, Екатерина Валериевна
Только метаданные
Antitumor activity of aminochromene derivative on the human-derived lung adenocarcinoma xenograft model in BALB/C nu/nu mice IÐIOEAIIIOOIEAAIA AAENOAEA IÐIECAIAIIAI AIEIIOÐIIAIA IA IIAAEE ENAIIAÐAOOA AAAIIEAÐOEIIIU EAAEIAI O IUØAE nu/nu BALB
(2021) Dudina, M. O.; Blinov, D. S.; Suslova, I. R.; Skachilova, S. Ya.; Blinova, E. V.; Блинова, Екатерина Валериевна
© 2021 Izdatel'stvo Meditsina. All rights reserved.The antitumor and anti-metastatic effects of aminochromene derivative AKh-554 upon intragastric administration were studied on immunodeficient BALB/c nu/nu female mice with heterotopic human-derived lung adenocarcinoma xenograft model. In the tumor tissue of animals treated with the test compound, the levels of TUBB3, ALK and c-MET/HFG oncomarkers were quantitatively detected and it was found that the drug suppressed the velocity of tumor growth and its size as well as exhibited anti-metastatic activity. AKh-554 produced 3.3-fold increase in tumor carriers survival and induced stable remission in 60% of test mice (p 0.001). The effect might be due to anti-ALK-dependent activation of apoptosis of tumor cells and suppression of cell proliferation. The results were obtained on the tumor system without signs of pharmacoresistance to AX-554, which was confirmed by the lack of dynamics of c-MET/HFG in tumor tissue in all test groups.
Открытый доступ
An effective way for targeting EGFR-mediated carcinogenesis: an in vitro study
(2024) Pakina, V. A.; Epishkina, A. A.; Grebenkin, E. V.; Blinova, E. V.; Епишкина, Анна Алексеевна; Гребенкин, Евгений Валерьевич; Блинова, Екатерина Валериевна
Introduction: EGFR-activating overexpression or somatic mutations are common in different human cancers. In this regard, the search for promising ways to control the carcinogenic transformation of tumor cells and the progression of malignant tumors expressing EGFR seems to be one of the most promising and developing areas of modern molecular pathology and pharmacology. Material and Methods: An antitumor activity of a novel compound, a pyridine carboxylic acid derivative LHT-17-19, was studied. The molecule was developed and synthesized at the Department of Chemistry, Drug Design and Technology of All-Russian Research Center for Biological Active Compounds Safety (Russia). The study was carried out in cell cultures of stomach cancer (Hs746T, AGS and MKN1) and patient-derived organoid (PDO) model of breast cancer (BC) expressing wild-type EGFR. Results: It was shown that LHT-17-19 induced concentration-dependent cytotoxicity of EGFR-expressing gastric cancer cells of all the aforementioned cultures. Pathomorphological, immunohistochemical and molecular validation of BC organoids derived from ductal breast carcinoma cells of a 68-year-old patient was done. PDOs were established as ER-negative, PR-negative, Her2/neu-negative, EGFR-positive with 35% of the Ki-67 expression index. In addition, the tumor cells translocation was resulted in a loss of ER expression and PDOs molecular pattern conversion towards a more aggressive triple negative type. PDOs incubation with 0.5-60.0 ‚?M LHT-17-19 was accompanied not only by inhibition of their growth and proliferation, but also by significant cytoreduction. Conclusion: Thus, in two-dimensional and three-dimensional tumor cell cultures, the possibility of controlling the oncogenic expression of EGFR with the acridone compound 9-ammonium-3,3-dimethyl-3,4-dihydroacridine-1(2H)-OH L-2-hydroxybutanedivacate (LHT-17-19) was shown.
Только метаданные
Fibrin as the mediator of tumor cell interaction with platelets
(2025) Tesakov, I.; Korneichuk, A. D.; Filkova, A. A.; Boldova, A. E.; Blinova, E. V.; Блинова, Екатерина Валериевна