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Калаева, Диана Борисовна

Организационные подразделения

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Инженерно-физический институт биомедицины

Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.

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Differential diagnosis of brain gliomas: The possibilities of dynamic pet-ct with 18f-fluorodeoxyglucose
(2021) Konakova, T. A.; Batalov, A. I.; Vikhrova, N. B.; Pronin, I. N.; Postnov, A. A.; Kalaeva, D. B.; Калаева, Диана Борисовна
© 2021 Russian Electronic Journal of Radiology. All rights reserved.Purpose. The aim of this prospective study, which included the analysis of data from 52 patients with primary brain gliomas, was to look for additional PET-CT bi-omarkers determined on the basis of the analysis of the first minute of dynamic PET scanning in order to increase the specificity and sensitivity of differential diagnosis of gliomas. 18F-FDG was administered simultaneously with the data collection began. Materials and methods. The study group included data of 52 patients, 27 men, 25 women, age 18-80 years, median 48 years + 12. Histologically, these were glioblastomas (n= 19), anaplastic astrocytomas (n=9), anaplastic oligodendrogliomas (n= 6), benign oligoden-drogliomas (n= 6), and diffuse astrocytomas (n=9). Each patient underwent a standard brain MR- study (T2, T2-FLAIR, T1, 3D T1 with contrast enhancement). The selected patients then underwent PET-CT examination (Siemens Truepoint scanner, Siemens Medical Solutions, USA) with radiopharmaceutical 18F-FDG according to the dynamic protocol developed in the our department. Data collection started simultaneously with intravenous administration of radiotracer for the next 40 minutes. 34 frames of 6X10 sec, 6x20 sec, 6x30 sec, 4x60 sec and 12x150 sec were reconstructed. Results. Among the proposed new PET parameters, T/N60s (accumulation index av-eraged over the first 60 seconds after the administration of 18 F-FDG) turned out to be the most successful, which made it possible to statistically reliably separate glioblastomas from all other histological subtypes of gliomas. Thus, for glioblastomas, T/N60s = 1.6 ± 0.4, and for anaplastic oligodendrogliomas, it was 1.1 ± 0.2, p<0.01. Moreover, T/N60s made it pos-sible to reliably differentiate not only Gr. II from gliomas Gr.III + Gr.IV, but also to differenti-ate glioblastomas from anaplastic astrocytomas (p<0.01) and glioblastomas from anaplastic and benign oligodendrogliomas (p<0.05 and p<0.01, respectively). All types of gliomas had an T/N60s>1.0, while its final accumulation could be lower than in intact tissue. A possible reason for this phenomenon may be tumor neoangiogenesis, which develops even in the case of low-grade gliomas. Conclusion. The use of the proposed technique for studying patients with brain gli-omas and analyzing the data obtained with the new PET biomarkers significantly improves the quality of differential diagnosis of gliomas using 18F-FDG. It also allows reducing the study time for one patient without losing the specificity and sensitivity of diagnosis.
Только метаданные
11C-methionine and 18F- fluorodeoxyglucose PET/CT in diagnosis of brain gliomas heterogeneity ПЭТ/КТ С 11С-МЕТИОНИНОМ И 18F-ФТОРДЕЗОКСИГЛЮКОЗОИ В ИЗУЧЕНИИ ГЕТЕРОГЕННОСТИ ГЛИОМ ГОЛОВНОГО МОЗГА
(2021) Vikhrova, N. B.; Batalov, A. I.; Konakova, T. A.; Khokhlova, E. V.; Kalaeva, D. B.; Postnov, A. A.; Калаева, Диана Борисовна
© 2021 Russian Electronic Journal of Radiology. All rights reserved.Purpose. The study of plastic and energy metabolism and their correlation with various histologic types of brain gliomas. Assessment of heterogeneity tumor structure and adjacent brain tissues by comparing MRI and 11C-methionine and 18F-fluorodeoxyglucose PET/CT data. Materials and methods. 52 patients (M/F 27/25, average age 48±12 years) with gliomas were enrolled in this study: glioblastoma (n = 19), anaplastic astrocytoma (n=9), diffuse astrocytoma (n=9), anaplastic oligodendroglioma (n=6), oligodendroglioma (n=6). Research protocol consisted from MRI before (T2, T2-FLAIR, 3DT1 (FSPGR) and after contrast enhancement (2DT1 (SE)) and dynamic MET and FDG PET/CT. Quantification parameters were: tumor to normal index (T/N) at last 10 min of time-activity curve (reflects the activity of metabolic processes), T/N in first peak of maximum uptake (Pmax) during first 60sec of study (reflects delivery level of radiopharmaceutical agent). Measurements were made in three areas: 1 – tumor core, 2 – edema/infiltration, 3 – intact brain tissue in close vicinity to the tumor borders (outside the T2-FLAIR hyperintensity zone). Сomparison was made between areas 1 and 2, 2and 3, and with intact brain tissue reference; MET and FDG accumulation correlations were studied. Results. Significant differences in T/N MET between areas 1 and 2 were obtained in all gliomas (p <0.05). Pmax MET differed only in glioblastomas (p <0.0001) and oligodendrogliomas (p <0.05), which correlated with the high level of vascularization of these tumor types. T/N FDG significantly differed between area 2 and 3 (p <0.05), which might allow to evaluate the boundaries of infiltrative growth of glioma, with mandatory comparison with MRI. Strong stable correlations of plastic and energy metabolism (as well as high level of radiopharmaceutical agent delivery) in the core of astrocytomas (Grade II-III) (Rs 0.8, p <0.05) and edema/infiltration area around of glioblastomas (Rs 0.5, p = 0, 02) were found and proved the evolutionary theory of glioma growth. Conclusion. The patterns of MET/FDG distribution as well as plastic and energy metabolism correlations in different tumor areas (core and edema/infiltration) and intact brain tissue in close vicinity to the tumor borders bring us closer to understanding the fundamental metabolic processes of brain gliomas.
Только метаданные
Dynamic 11C-methionine PET/CT in differential diagnosis of brain gliomas
(2021) Vikhrova, N. B.; Khokhlova, E. V.; Konakova, T. A.; Batalov, A. I.; Kalaeva, D. B.; Postnov, A. A.; Калаева, Диана Борисовна
© N.B. VIKHROVA, D.B. KALAEVA, A.A. POSTNOV, E.V. KHOKHLOVA, T.A. KONAKOVA, A.I. BATALOV, E.L. POGOSBEKYAN, I.N. PRONIN.Objective. To evaluate the possibilities of dynamic preoperative 11C-methionine (MET) PET/CT in differential diagnosis of various types of brain gliomas in adults. Material and methods. The study included 74 patients aged 48±14 years with supratentorial gliomas: Grade IV - glioblastoma (GB, n=33), Grade III - anaplastic oligodendroglioma (AOD, n=10) and anaplastic astrocytoma (AA, n=12), Grade II - diffuse astrocytoma (DA, n=13) and oligodendroglioma (OD, n=6). All patients underwent standard MRI and dynamic MET PET/CT within 20 minutes after intravenous injection of radiopharmaceutical. Then, we compared MRI and PET/CT data and comprehensively analyzed the early stages of time-activity curve using 2 parameters: the first pass peak (FPP) and the first peak of maximum uptake (Pmax). Results. We have significantly distinguished high-grade tumors (GB and AA+AOD) and certain benign gliomas (DA and OD) (p<0.05). AUC was over 0.7 and 0.8 for FPP and Pmax in differential diagnosis of various gliomas, respectively. We found that difficulties in differential diagnosis of gliomas arise mainly if oligodendrogliomas are included in the control group. Conclusion. Dynamic PET/CT with analysis of FPP and Pmax increases specificity of differential diagnosis of various gliomas compared to standard static imaging. These data are valuable for choice of optimal treatment strategy, as well as fundamental research of metabolic processes and vascularization of various tumors.
Только метаданные
Non-invasive measurement of oxygen metabolism. Part 2: new techniques in PET and MRI Неинвазивное измерение метаболизма кислорода. Часть 2: новые методики в ПЭТ и МРТ
(2024) Postnov, A. A.; Kalaeva, D. B.; Balakhonov, A. B.; Pronin, I. N.; Калаева, Диана Борисовна
Oxygen metabolism is a key factor in the life of a living organism. The article is the second part of a review of methods for measuring oxygen metabolism. Purpose. The aim of this review is to provide an insight into newly developed perfusion measurement techniques based on MRI and CT comparing their accuracy with the вЂњgold standardвЂќ H 2 15 O PET measurements and describing their role in todayвЂ™s clinical practice. Materials and methods. More than 200 Pubmed publications were analyzed for the keywords вЂњperfusion, MRI, CT, ASL, oxygen metabolismвЂќ. Relevant publications that do not contain these keywords or contain them in a different wording were also studied. Results. This review selected 49 publications describing CT and MR perfusion using contrast agents and MR ASL perfusion. Examples of the use of the described methods in fundamental research and applied medicine are given. Conclusion. The quantitative results obtained using novel non-invasive molecular imaging techniques are in most cases comparable to H 2 15 O PET data, which opens the way for broad use of MRI and CT perfusion and oxygen metabolism measurements in clinical practice.
Только метаданные
Influence of 11C-MET PET acquisition time for differential diagnosis of human brain gliomas
(2021) Vikhrova, N.; Batalov, A.; Konakova, T.; Khokhlova, E.; Postnov, A.; Kalaeva, D.; Калаева, Диана Борисовна
© 2021 Institute of Physics Publishing. All rights reserved.The aim of this work was to study the effect of the reduced acquisition time of PET 11C-MET examination on the quality of primary brain tumors differential diagnosis. 57 patients with histologically verified diagnoses were recruited (glioblastoma n=20, anaplastic astrocytoma n=11, diffuse astrocytoma n=11, oligodendroglioma n=9 and anaplastic oligodendroglioma n=6). The scan time was varied in the range of 2-20 min. Our study demonstrated that in the case of intravenous administration of 11C-MET simultaneously with the start of scanning, the quality of primary gliomas differential diagnosis does not depend on the scan time. Therefor it becomes possible increasing the number of patients and reducing the acquisition time. The T/N60 ratio (T/N ratio measured in the first 60 seconds after 11C-MET intravenous injection) is equally successful parameter for glioma differential diagnosis as the traditional T/N ratio.
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Radiological biomarkers of brain gliomas
(2022) Tyurina, A. N.; Vikhrova, N. B.; Batalov, A. I.; Shults, E. I.; Pronin, I. N.; Kalaeva, D. B.; Postnov, A. A.; Калаева, Диана Борисовна
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First-in-Man Noninvasive Initial Diagnostic Approach of Primary CNS Lymphoma Versus Glioblastoma Using PET with 18F-Fludarabine and l -[methyl-11C]Methionine
(2022) Toutain, J.; Pronin, I.; Valable, S.; Gourand, F.; Postnov, A.; Kalaeva, D.; Калаева, Диана Борисовна
© 2022 Wolters Kluwer Health, Inc.Objectives This study sought to assess 18F-fludarabine (18F-FLUDA) PET/CT's ability in differentiating primary central nervous system lymphomas (PCNSLs) from glioblastoma multiformes (GBMs). Patients and Methods Patients harboring either PCNSL (n = 8) before any treatment, PCNSL treated using corticosteroids (PCNSLh; n = 10), or GBM (n = 13) were investigated with conventional MRI and PET/CT, using 11C-MET and 18F-FLUDA. The main parameters measured with each tracer were SUVT and T/N ratios for the first 30 minutes of 11C-MET acquisition, as well as at 3 different times after 18F-FLUDA injection. The early 18F-FLUDA uptake within the first minute of injection was equally considered, whereas this parameter was combined with the later uptakes to obtain R FLUDA 2 and R FLUDA 3 ratios. Results No significant differences in 11C-MET uptakes were observed among PCNSL, PCNSLh, and GBM. With 18F-FLUDA, a clear difference in dynamic GBM uptake was observed, which decreased over time after an early maximum, as compared with that of PCNSL, which steadily increased over time, PCNSLh exhibiting intermediate values. The most discriminative parameters consisting of R FLUDA 2 and R FLUDA 3 integrated the early tracer uptake (first 60 seconds), thereby provided 100% specificity and sensitivity. Conclusions 18F-FLUDA was shown to likely be a promising radiopharmaceutical for differentiating PCNSL from other malignancies, although a pretreatment with corticosteroids might compromise this differential diagnostic ability. The diagnostic role of 18F-FLUDA should be further investigating, along with its potential of defining therapeutic strategies in patients with PCNSL, while assessing the treatments' effectiveness.
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PET/CT with 11 C-methionine in assessment of brain glioma metabolism
(2024) Vikhrova, N. B.; Kalaeva, D. B.; Tyurina, A. N.; Belyaev, A. Yu.; Калаева, Диана Борисовна
Открытый доступ
Radiomics in Determining Tumor-to-Normal Brain SUV Ratio Based on11C-Methionine PET/CT in Glioblastoma
(2023) Danilov, G. V.; Kalaeva, D. B.; Vikhrova, N. B.; Konakova, T. A; Postnov, A. A.; Калаева, Диана Борисовна
"Modern methodology of PET/CT quantitative analysis in patients with glioblastomas is not strictly standardized in clinic settings and does not exclude the influence of the human factor.Methods of radiomics may facilitate unification, and improve objectivity and efficiency of the medical image analysis.The aim of the study is to evaluate the potential of radiomics in the analysis of PET/CT glioblastoma images identifying the relationship between the radiomic features and the 11 РЎ-methionine tumor-to-normal brain uptake ratio (TNR) determined by an expert in routine.Materials and Methods.PET/CT data (2018-2020) from 40 patients (average age was 55В±12 years; 77.5% were males) with a histologically confirmed diagnosis of ""glioblastoma"" were included in the analysis.TNR was calculated as a ratio of the standardized uptake value of 11 C-methionine measured in the tumor and intact tissue.Calculation of radiomic features for each PET was performed in the specified volumetric region of interest, capturing the tumor with the surrounding tissues.The relationship between TNR and the radiomic features was determined using the linear regression model.Predictors were included in the model following correlation analysis and LASSO regularization.The experiment with machine learning was repeated 300 times, splitting the training (70%) and test (30%) subsets randomly.The model quality metrics and predictor significance obtained in 300 tests were summarized.Results.Of 412 PET/CT radiomic parameters significantly correlated with TNR (p<0.05), the regularization procedure left no more than 30 in each model (the median number of predictors was 9 [7; 13]).The experiment has demonstrated a non-random linear correlation (the Spearman correlation coefficient was 0.58 [0.43; 0.74]) between TNR and separate radiomic features, primarily fractal dimensions, characterizing the geometrical properties of the image. Conclusion.Radiomics enabled an objective determination of PET/CT image texture features reflecting the biological activity of glioblastomas.Despite the existing limitations in the application, the first results provide a good perspective of these methods in neurooncology."
Открытый доступ
Non-invasive measurement of oxygen metabolism. Part 1: Historical review and state of the art Неинвазивное измерение метаболизма кислорода. Часть 1: историческии обзор и современное состояние
(2023) Postnov, A. A.; Kalaeva, D. B.; Balakhonov, A. B.; Pronin, I. N.; Калаева, Диана Борисовна
Oxygen metabolism is a key factor in the life of a living organism. The article is the first part of a review of methods for measuring oxygen metabolism. Purpose. The aim of this review is to present an insight into the evolution of methods for measuring oxygen metabolism in a way from global to local measurement of brain perfusion. The role of the 15 O isotope as the вЂњgold standardвЂќ for measuring oxygen metabolism using positron emission tomography (PET) is described. We also provide a case report of brain tumor perfusion measurements from our clinic. Materials and methods. More than 200 Pubmed publications were studied with the keywords вЂњpositron emission tomography + O-15вЂќ. Relevant publications that do not contain these keywords or contain them in a different wording were also analyzed. A clinical case of a brain tumor perfusion using CT perfusion, MR-ASL and PET with H 2 15 O is provided. Results. The evolution of methods for measuring perfusion, oxygen extraction, and oxygen metabolism, is described. More than 50 papers are cited depicting key advances in measurement technologies. Examples of the use of PET with H 2 15 O in fundamental research and clinical practice are given. Conclusion. The obvious value of oxygen-isotope PET data is combined with the invasiveness (in some cases), technical complexity and high cost of the procedure. The second part of the review will be devoted to alternative methods for measuring oxygen metabolism, which are developing in the 21st century and which are intended for wide clinical use.