Publication:
Dynamic 11C-methionine PET/CT in differential diagnosis of brain gliomas

Дата
2021
Авторы
Vikhrova, N. B.
Khokhlova, E. V.
Konakova, T. A.
Batalov, A. I.
Kalaeva, D. B.
Postnov, A. A.
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Научные группы
Организационные подразделения
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Организационная единица
Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Аннотация
© N.B. VIKHROVA, D.B. KALAEVA, A.A. POSTNOV, E.V. KHOKHLOVA, T.A. KONAKOVA, A.I. BATALOV, E.L. POGOSBEKYAN, I.N. PRONIN.Objective. To evaluate the possibilities of dynamic preoperative 11C-methionine (MET) PET/CT in differential diagnosis of various types of brain gliomas in adults. Material and methods. The study included 74 patients aged 48±14 years with supratentorial gliomas: Grade IV - glioblastoma (GB, n=33), Grade III - anaplastic oligodendroglioma (AOD, n=10) and anaplastic astrocytoma (AA, n=12), Grade II - diffuse astrocytoma (DA, n=13) and oligodendroglioma (OD, n=6). All patients underwent standard MRI and dynamic MET PET/CT within 20 minutes after intravenous injection of radiopharmaceutical. Then, we compared MRI and PET/CT data and comprehensively analyzed the early stages of time-activity curve using 2 parameters: the first pass peak (FPP) and the first peak of maximum uptake (Pmax). Results. We have significantly distinguished high-grade tumors (GB and AA+AOD) and certain benign gliomas (DA and OD) (p<0.05). AUC was over 0.7 and 0.8 for FPP and Pmax in differential diagnosis of various gliomas, respectively. We found that difficulties in differential diagnosis of gliomas arise mainly if oligodendrogliomas are included in the control group. Conclusion. Dynamic PET/CT with analysis of FPP and Pmax increases specificity of differential diagnosis of various gliomas compared to standard static imaging. These data are valuable for choice of optimal treatment strategy, as well as fundamental research of metabolic processes and vascularization of various tumors.
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Цитирование
Dynamic 11C-methionine PET/CT in differential diagnosis of brain gliomas / Vikhrova, N.B. [et al.] // Zhurnal Voprosy Nejrokhirurgii Imeni N.N. Burdenko. - 2021. - 85. - № 3. - P. 5-11. - 10.17116/neiro2021850315
URI
https://www.doi.org/10.17116/neiro2021850315
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85109092250&origin=resultslist
 https://openrepository.mephi.ru/handle/123456789/24323
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