Персона: Набиев, Игорь Руфаилович
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Игорь Руфаилович
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- ПубликацияОткрытый доступOn-demand reversible switching of the emission mode of individual semiconductor quantum emitters using plasmonic metasurfaces(2024) Olejniczak, A.; Lawera, Z.; Zapata-Herrera, M.; Samokhvalov, P. S.; Nabiev, I.; Набиев, Игорь РуфаиловичThe field of quantum technology has been rapidly expanding in the past decades, yielding numerous applications, such as quantum information, quantum communication, and quantum cybersecurity. At the core of these applications lies the quantum emitter (QE), a precisely controllable generator of either single photons or photon pairs. Semiconductor QEs, such as perovskite nanocrystals and semiconductor quantum dots, have shown much promise as emitters of pure single photons, with the potential for generating photon pairs when hybridized with plasmonic nanocavities. In this study, we have developed a system in which individual quantum emitters and their ensembles can be traced before, during, and after the interaction with an external plasmonic metasurface in a controllable way. Upon coupling the external plasmonic metasurface to the QE array, the individual QEs switch from the single-photon emission mode to the multiphoton emission mode. Remarkably, this method preserves the chemical structure and composition of the QEs, allowing them to revert to their initial state after decoupling from the plasmonic metasurface. This significantly expands the potential applications of semiconductor QEs in quantum technologies.
- ПубликацияОткрытый доступDouble Rabi Splitting in a Strongly Coupled System of Core-Shell Au@Ag Nanorods and J-Aggregates of Multiple Fluorophores(2019) Melnikau, D.; Govyadinov, A. A.; Sanchez-Iglesias, A.; Grzelczak, M.; Nabiev, I. R.; Liz-Marzan, L. M.; Rakovich, Y. P.; Набиев, Игорь РуфаиловичCopyright © 2019 American Chemical Society.The interaction of several components in the strong coupling regime yielding multiple Rabi splittings opens up remarkable possibilities for studies of multimode hybridization and energy transfer, which is of considerable interest in both fundamental and applied science. Here we demonstrate that three different components, such as core-shell Au@Ag nanorods and J-aggregates of two different dyes, can be integrated into a single hybrid structure, which leads to strong collective exciton-plasmon coupling and double-mode Rabi splitting totaling 338 meV. We demonstrate strong coupling in these multicomponent plexitonic nanostructures by means of magnetic circular dichroism spectroscopy and demonstrate strong magneto-optical activity for the three hybridized states resulting from this coupling. The J-aggregates of two different nonmagnetic dyes interact with metal nanoparticles effectively, achieving magnetic properties due to the hybridization of electronic excitations in the three-component system. ©
- ПубликацияТолько метаданныеOptical properties of PBS-GO and PBS-RGO system for solar cells fabrication(2019) Babaev, A.; Dubavik, A.; Cherevkov, S.; Parfenov, P.; Nabiev, I.; Набиев, Игорь Руфаилович© NANOCON 2018 - Conference Proceedings, 10th Anniversary International Conference on Nanomaterials - Research and Application. All rights reserved. Quantum dots (QDs) are of great interest for creating optoelectronic devices due to their tunable bandgap, high stability and simple solution processability for device fabrication. One of the ways to increase the efficiency of such devices is to combine QDs with different carbon nanostructures. Lead sulfide PbS QDs with a ligand shell of oleic acid (OA), methylammonium iodide (MAI) and PbI2 were employed to study the process of charge transfer process between QDs and sheets of reduced graphene oxide (rGO) and graphene oxide (GO). QDs have been linked to graphene sheets by the (3-mercaptopropyl) trimethoxysilane in colloidal solution. As a result, we observed a change in intensity and kinetics of QDs PL, that allowed to estimate the efficiency of the charge transfer. The transfer efficiency for the QD-rGO system was found to be higher than that of the QD-GO system, ~ 80 % vs. 66 % respectively. Modification of the QDs surface with MAI and PbI2 allowed to achieve a charge transfer efficiency of up to 83 % and 89 %, respectively.
- ПубликацияОткрытый доступTwo-photon photoluminescence of a thin-film hybrid material based on CdSe(core)/ZnS/CdS/ZnS(multishell) semiconductor quantum dots(2019) Dyagileva, D. V.; Krivenkov, V. A.; Samokhvalov, P. S.; Nabiev, I.; Rakovich, Yu. P.; Самохвалов, Павел Сергеевич; Набиев, Игорь Руфаилович© Published under licence by IOP Publishing Ltd.Semiconductor quantum dots (QDs) are widely used as components of hybrid materials for development of efficient light emitters and convertors. Their unique nonlinear optical properties, such as two-photon absorption and two-photon photoluminescence from biexcitons, make them promising materials for photovoltaic and optoelectronic applications. In this study, thin-film hybrid materials based on the CdSe(core)/ZnS/CdS/ZnS(multishell) QDs have been fabricated, and the two-photon photoluminescence (PL) from the generated biexcitons have been studied. The results show that fabricated thin-film hybrid materials based on the QDs are efficient fluorophores in the one- and two-photon PL regimes for applications in optoelectronics and biosensing.
- ПубликацияТолько метаданныеAbsolute two-photon absorption cross-sections of single-exciton states in semiconductor nanocrystals(2020) Krivenkov, V.; Samokhvalov, P.; Dyagileva, D.; Nabiev, I.; Самохвалов, Павел Сергеевич; Набиев, Игорь Руфаилович© 2020 SPIE.Semiconductor nanocrystals (SNCs), in particular, quantum dots (QDs) and nanoplatelets (NPLs), have orders of magnitude higher two-photon absorption cross-sections (TPACS) than organic dyes, what paves the way to their advanced applications in bioimaging, sensing, and optoelectronics. Traditionally, z-scan and two-photon photoluminescence (PL) excitation spectroscopy are used to determine the TPACS values. The main disadvantage of both methods is the necessity to know the exact sample concentration. In this study, we describe an approach to the TPACS determination from the analysis of two-photon-excited (TPE) PL saturation in CdSe(core)/ZnS/CdS/ZnS(multishell) QDs and CdSe NPLs. The results obtained for NPLs using developed approach are significantly smaller than those obtained by the z-scan method and are close to the values obtained for QDs. We assume that this discrepancy occurs due to the fact, that unlike the z-scan technique, the TPE PL saturation method measures the TPACS only for single-exciton states because of the low PL quantum yields of multiexciton states. Therefore, there is no need to know the concentration, which eliminates the corresponding estimation error. Thus, the measurement of TPE PL saturation in SNCs makes it possible to determine the absolute values of the TPACS of single-exciton states, which are more informative for applications of TPE PL than the TPACS of mixed multiexciton states.
- ПубликацияТолько метаданныеFine Tuning Phosphonate Synthesis Yields of CsPbBr3 Perovskite Nanocrystals with Enhanced Stability for Applications in Quantum Technologies(2024) Samokhvalov, P. S.; Gusev, A. S.; Siglovaya, N. V.; Kargin, N. I.; Nabiev, I. R.; Самохвалов, Павел Сергеевич; Гусев, Александр Сергеевич; Сигловая, Наталия Владимировна; Каргин, Николай Иванович; Набиев, Игорь Руфаилович
- ПубликацияТолько метаданныеQuantum dot-based plasmon-exciton emitters with improved one- And two-photon emission properties(2021) Rakovich, Y.; Krivenkov, V.; Samokhvalov, P.; Nabiev, I.; Самохвалов, Павел Сергеевич; Набиев, Игорь Руфаилович© 2021 SPIE.Photoluminescence (PL) properties of semiconductor quantum dots (QDs) may be significantly improved by forming hybrid structures with plasmonic nanoparticles (PNPs). In general, three main effects can be observed when QDs are placed near PNPs - a local enhancement of excitation, acceleration of radiative recombination rate (Purcell effect), and acceleration of nonradiative relaxation rate due to the metal-induced energy transfer. All these effects lead to an increase in PL quantum yield (QY), excitonic (EX) and biexcitonic (BX) states and to the strong reduction of PL lifetime. In this study, we investigated the EX and BX PL parameters of single QDs in the vicinity of PNPs at different overlapping between the excitation wavelength, QDs PL, and PNPs extinction spectra. Here, we have fabricated thin films of QDs separated from the environment by the polymer spacer, and placed PNPs atop of these structures under the continuous observation of optical parameter of the same single QD. We have found that the excitation may be strongly increased in the case of a strong spectral overlap between excitation band and PNPs extinction. Nevertheless, the EX QY is strongly reduced by the energy transfer. In the case of strong spectral overlap between QDs PL and PNPs extinction, the radiative rate is increased, which leads to an increase of both EX and BX QYs and to a near-unity BX-to-EX QY ratio. Finally, we managed to combine these two effects in one material with a synergistically increased PL intensity, ultrashort PL lifetime, and levelling of EX and BX QY.
- ПубликацияОткрытый доступGraphene quantum dots unraveling: Green synthesis, characterization, radiolabeling with 99mTc, in vivo behavior and mutagenicity(2019) de, Menezes, F. D.; dos, Reis, S. R. R.; Pinto, S. R.; Portilho, F. L.; Sukhanova, A.; Nabiev, I. R.; Суханова, Алена Владимировна; Набиев, Игорь Руфаилович© 2019 Graphene is one of the crystalline forms of carbon, along with diamond, graphite, carbon nanotubes, and fullerenes, and is considered as a revolutionary and innovating product. The use of a graphene-based nanolabels is one of the latest and most prominent application of graphene, especially in the field of diagnosis and, recently, in loco radiotherapy when coupled with radioisotopes. However, its biological behavior and mutagenicity in different cell or animal models, as well as the in vivo functional activities, are still unrevealed. In this study we have developed by a green route of synthesizing graphene quantum dots (GQDs)and characterized them. We have also developed a methodology for direct radiolabeling of GQDs with radioisotopes.Finally; we have evaluated in vivo biological behavior of GQDs using two different mice models and tested in vitro mutagenicity of GQDs. The results have shown that GQDs were formed with a size range of 160-280 nm, which was confirmed by DRX and Raman spectroscopy analysis, corroborating that the green synthesis is an alternative, environmentally friendly way to produce graphene. The radiolabeling test has shown that stable radiolabeled GQDs can be produced with a high yield (>90%). The in vivo test has demonstrated a ubiquitous behavior when administered to healthy animals, with a high uptake by liver (>26%)and small intestine (>25%). Otherwise, in an inflammation/VEGF hyperexpression animal model (endometriosis), a very peculiar behavior of GQDs was observed, with a high uptake by kidneys (over 85%). The mutagenicity test has demonstrated A:T to G:C substitutions suggesting that GQDs exhibits mutagenic activity.
- ПубликацияТолько метаданныеSurface-enhanced Raman scattering of CoV-SARS-2 viral proteins in a strong coupling regime(2021) Sukhanova, A.; Mochalov, K.; Samokhvalov, P.; Nifontova, G.; Tsoi, T.; Nabiev, I.; Самохвалов, Павел Сергеевич; Нифонтова, Галина Олеговна; Цой, Татьяна Дмитриевна; Набиев, Игорь Руфаилович© 2021 Institute of Physics Publishing. All rights reserved.Fast, sensitive, high-throughput detection of coronavirus antigens at physiologically relevant levels is essential for population screening that could prevent epidemics such as the current COVID-19 global pandemic. Optical methods based on surface-enhanced Raman scattering (SERS) spectroscopy are promising for this purpose because they ensure quick detection of even single biological molecules in a sample. For achieving such a high sensitivity, it is crucial to design SERS-active systems concentrating incident radiation into small sample volumes. Here, metal-dielectric cavities have been obtained through interaction of protein sulfhydryl groups with a SERS-active silver surface. The concentration of light in these cavities allows the differential detection of spike glycoprotein and nucleocapsid protein of SARS-COV-2, which are its key antigens, at physiologically relevant concentrations. The cavity Q-factor can be increased by additionally covering the dielectric protein film with a silver shell to form an ultrathin cavity, which provides an at least tenfold enhancement of the detection signal. The results could be used to design high-throughput systems for specific and sensitive detection of viral antigens and quick diagnosis of viral infections.
- ПубликацияОткрытый доступNontoxic Fluorescent Nanoprobes for Multiplexed Detection and 3D Imaging of Tumor Markers in Breast Cancer(2023) Sokolov, P.; Nifontova, G.; Samokhvalov, P.; Nabiev, I.; Соколов, Павел Михайлович; Самохвалов, Павел Сергеевич; Набиев, Игорь РуфаиловичMultiplexed fluorescent immunohistochemical analysis of breast cancer (BC) markers and high-resolution 3D immunofluorescence imaging of the tumor and its microenvironment not only facilitate making the disease prognosis and selecting effective anticancer therapy (including photodynamic therapy), but also provides information on signaling and metabolic mechanisms of carcinogenesis and helps in the search for new therapeutic targets and drugs. The characteristics of imaging nanoprobe efficiency, such as sensitivity, target affinity, depth of tissue penetration, and photostability, are determined by the properties of their components, fluorophores and capture molecules, and by the method of their conjugation. Regarding individual nanoprobe components, fluorescent nanocrystals (NCs) are widely used for optical imaging in vitro and in vivo, and single-domain antibodies (sdAbs) are well established as highly specific capture molecules in diagnostic and therapeutic applications. Moreover, the technologies of obtaining functionally active sdAb-NC conjugates with the highest possible avidity, with all sdAb molecules bound to the NC in a strictly oriented manner, provide 3D-imaging nanoprobes with strong comparative advantages. This review is aimed at highlighting the importance of an integrated approach to BC diagnosis, including the detection of biomarkers of the tumor and its microenvironment, as well as the need for their quantitative profiling and imaging of their mutual location, using advanced approaches to 3D detection in thick tissue sections. The existing approaches to 3D imaging of tumors and their microenvironment using fluorescent NCs are described, and the main comparative advantages and disadvantages of nontoxic fluorescent sdAb-NC conjugates as nanoprobes for multiplexed detection and 3D imaging of BC markers are discussed.