Персона: Белогорлов, Антон Анатольевич
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Институт нанотехнологий в электронике, спинтронике и фотонике
Институт ИНТЭЛ занимается научной деятельностью и подготовкой специалистов в области исследования физических принципов, проектирования и разработки технологий создания компонентной базы электроники гражданского и специального назначения, а также построения современных приборов на её основе.
Наша основная цель – это создание и развитие научно-образовательного центра мирового уровня в области наноструктурных материалов и устройств электроники, спинтроники, фотоники, а также создание эффективной инновационной среды в области СВЧ-электронной и радиационно-стойкой компонентной базы, источников ТГц излучения, ионно-кластерных технологий материалов.
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- ПубликацияТолько метаданныеNanostructured Porous Silicon Containers as Drug Carriers(2021) Akopdzhanov, A. G.; Shimanovsky, N. L.; Belogorlov, A. A.; Bortnikova, S. A.; Белогорлов, Антон Анатольевич; Бортникова, Светлана Алексеевна© 2021, Springer Science+Business Media, LLC, part of Springer Nature.The possibilities of using porous silicon nanostructured containers as drug carriers are considered. The main design principles of the nanocontainers and the possibility of using pore surface modification to achieve the optimal regimes of drug loading and controlled in vivo drug release are formulated. Results from studies devoted to the application of porous silica containers are presented. The main prospects and research tasks in this field are related to reducing the object size, increasing the biocompatibility, increasing the drug loading volume, and achieving the optimal drug release kinetics.
- ПубликацияТолько метаданныеPore-Surface Modification as a Method of Controlling the Relaxation of a Nonwetting Liquid Dispersed in a Nanoporous Medium(2021) Mingalev, P. G.; Bortnikova, S. A.; Belogorlov, A. A.; Бортникова, Светлана Алексеевна; Белогорлов, Антон Анатольевич© 2021, Pleiades Publishing, Ltd.This work presents the results of studying hydrophobized silica gel Fluka 100 C8 + C1 with additional chemical surface modification by single-link alkylsilane. The material is studied by low-temperature nitrogen sorption and liquid porometry, including additional liquid porometry methods. The results of studying the system without additional modification are also presented. All results are presented for three temperatures: 20, 40, and 60°C. It is shown that additional chemical modification allows an increase in the fraction of the nonwetting liquid flowing from the pores with increasing temperature while maintaining a significant proportion of nonwetting liquid that has not outflowed under normal conditions. The obtained results show that, by additional modification, it is possible to control the process of the time relaxation of a nonwetting liquid in a nanoporous medium.
- ПубликацияТолько метаданныеOutflow Kinetics of Chemical Solutions from Hydrophobized Nanostructural Silicon Compounds: Effect of Surface Tension(2021) Shimanovsky, N. L.; Belogorlov, A. A.; Khrebtov, D. S.; Bortnikova, S. A.; Белогорлов, Антон Анатольевич; Бортникова, Светлана Алексеевна© 2021, Springer Science+Business Media, LLC, part of Springer Nature.The outflow kinetics of aqueous solutions of n-propanol as model liquids (drug solutions) from hydrophobic nanoporous silica gel 60 C8 was studied. The solution surface tension was shown to influence the hysteresis of intrusion-extrusion pressures and outflow rate. The use of substances changing the surface tension of the injected solution, in particular doxorubicin, allows one to control the relaxation/release of doxorubicin molecules in/from the focus of the disorder at the optimum rate. The obtained results can be used to create drug delivery systems based on silicon nanoparticles.
- ПубликацияТолько метаданныеAntiproliferative Activity of Nanoporous Silica-Containing Particles as Carriers of MIR-34A Against Cancer Cell Cultures(2025) Akopdzhanov, A. G.; Pavlik, T. I.; Bortnikova, S. A.; Belogorlov,A.A.; Бортникова, Светлана Алексеевна; Белогорлов, Антон Анатольевич
- ПубликацияОткрытый доступHysteresis of Percolation Transition and Relaxation of Fast and Slow States of the System Nanoporous Medium-Non-Wetting Liquid(2020) Belogorlov, A. A.; Borman, V. D.; Bortnikova, S. A.; Byrkin, V. A.; Tronin, I. V.; Tronin, V. N.; Белогорлов, Антон Анатольевич; Бортникова, Светлана Алексеевна; Быркин, Виктор Александрович; Тронин, Иван Владимирович© 2020 Published under licence by IOP Publishing Ltd.In the present paper we present the results of experimental and theoretical studies of intrusion-extrusion and relaxation of non-wetting liquid in three Fluka porous media. New data on hysteresis of intrusion-extrusion and dependence of the degree of filling of a porous body on time in the process of extrusion were obtained experimentally. It has been established that in all the conducted experiments the liquid extrusion took place in two stages: at the first stage of fast relaxation the characteristic time of outflow is several seconds, at the second stage of slow relaxation the characteristic time is several hundred seconds. The experimental data obtained are described in the theoretical model [1]. For the studied porous media, the existence at the initial moment of time of local states with short leakage times (a few seconds or less) and states with large leakage times (hundreds of seconds) was established. Porous bodies in which the coexistence of fast and slow states at the initial moment of time is established are investigated for the first time.
- ПубликацияОткрытый доступLocal Configurations of Pores that Course Non-Wetting Liquid Non Outflow(2020) Bortnikova, S. A.; Belogorlov, A. A.; Borman, V. D.; Бортникова, Светлана Алексеевна; Белогорлов, Антон Анатольевич© 2020 Published under licence by IOP Publishing Ltd.It is known that for the most nanoporous medium-non-wetting liquid systems are observed non-outflow phenomenon. It is shown that this phenomenon may depend on many factors, one of which is a waiting time. The observed anomalously slow relaxation (non-wetting liquid outflow) caused by formation of strongly interacting states of liquid clusters in pores. Previously was shown that relaxation of such states can occur due to relaxation of metastable local configurations of filled and empty pores. In the present work the relaxation of non-wetting liquid (water) dispersed in disordered nanoporous medium (hydrophobic silica gel Libersorb 23) for 6 and 9° C is considered. The pore size distribution functions of captured liquid for 9° C are obtained. Some local configurations for 6 and 9° C are analyzed and their lifetimes are defined.
- ПубликацияОткрытый доступRelaxation of Non-Wetting Liquid Dispersed in Nanoporous Medium with Partial Filling(2020) Bortnikova, S. A.; Belogorlov, A. A.; Borman, V. D.; Byrkin, V. A.; Бортникова, Светлана Алексеевна; Белогорлов, Антон Анатольевич; Быркин, Виктор Александрович© 2020 Published under licence by IOP Publishing Ltd.In the present work the results of experimental studies of relaxation of non-wetting liquid captured by the system of nanopores of Fluka 100 C8+C1 medium are presented. New data on dependence of filling degree on time in the process of outflow at partial initial filling have been obtained. In all the experiments carried out, fluid outflow was carried out in two stages: in the first stage of fast relaxation the characteristic time of outflow is a few seconds, in the second stage of slow relaxation the characteristic time can reach 104 seconds. It was found that "fast"states exist at any initial filling, and the degree of these states increases both with increasing temperature and with increasing initial filling of nanoporous medium with non-wetting liquid.
- ПубликацияОткрытый доступStudy of the model system for delivery and controlled release of anticancer drugs in affected areas.(2020) Mingalev, P. G.; Akopdzhanov, A. G.; Shimanovskii, N. L.; Belogorlov, A. A.; Bortnikova, S. A.; Kulakov, S. A.; Белогорлов, Антон Анатольевич; Бортникова, Светлана Алексеевна; Кулаков, Сергей Алексеевич© 2020 Published under licence by IOP Publishing Ltd.The modern clinical oncology key task is to increase the efficiency of anticancer chemical therapy. The main direction of provided investigations are to ensure targeted delivery of drugs to cancer cells with the minimization of the harmful effect to normal cells, as well as overcoming the multiple drug resistance of cancer cells. One of the possible solutions is to use nanoporous medium filled with non-wetting liquid (drug) as a carrier. Interest to such systems is caused by two effects observed for such systems: the effect of non-wetting liquid dispersion in pores and it's anomalously slow relaxation (outflow). It has also been shown that these effects are critically dependent on temperature. The work is present results of experimental study of the kinetics of model liquid outflow from nanoporous medium at the temperature range 20-40 °C. Results obtained for systems with different granule sizes and surface modifications.