Publication: Study of the model system for delivery and controlled release of anticancer drugs in affected areas.
Дата
2020
Авторы
Mingalev, P. G.
Akopdzhanov, A. G.
Shimanovskii, N. L.
Belogorlov, A. A.
Bortnikova, S. A.
Kulakov, S. A.
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© 2020 Published under licence by IOP Publishing Ltd.The modern clinical oncology key task is to increase the efficiency of anticancer chemical therapy. The main direction of provided investigations are to ensure targeted delivery of drugs to cancer cells with the minimization of the harmful effect to normal cells, as well as overcoming the multiple drug resistance of cancer cells. One of the possible solutions is to use nanoporous medium filled with non-wetting liquid (drug) as a carrier. Interest to such systems is caused by two effects observed for such systems: the effect of non-wetting liquid dispersion in pores and it's anomalously slow relaxation (outflow). It has also been shown that these effects are critically dependent on temperature. The work is present results of experimental study of the kinetics of model liquid outflow from nanoporous medium at the temperature range 20-40 °C. Results obtained for systems with different granule sizes and surface modifications.
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Study of the model system for delivery and controlled release of anticancer drugs in affected areas. / Mingalev, P.G. [et al.] // Journal of Physics: Conference Series. - 2020. - 1696. - № 1. - 10.1088/1742-6596/1696/1/012032