Персона: Савельева, Татьяна Александровна
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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- ПубликацияТолько метаданныеIntraoperative control of hemoglobin oxygen saturation in the intestinal wall during anastomosis surgery(2021) Kustov, D. M.; Kharnas, S. S.; Levkin, V. V.; Gorbunov, A. S.; Savelieva, T. A.; Mironov, T. A.; Loschenov, V. B.; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович© 2021 by the authors. Licensee MDPI, Basel, Switzerland.During surgery for colon cancer, monitoring of the oxygen saturation of hemoglobin in the tissues under study makes it possible to assess the degree of blood supply to the anastomosis areas of the colon. Adequate blood supply in this area is decisive in terms of the consistency of the anastomosis and can significantly reduce the risk leakage of anastomosis. In this work, we propose a new approach to assessing the hemoglobin oxygen saturation based on measuring both the diffuse reflectance and transmittance spectra of the colon wall tissues. The proposed method is based on the use of two fiber-optic tools for irradiation from both sides—the intestinal lumen and the outside of the intestinal wall. The spectra are recorded from the external side. To determine the degree of hemoglobin saturation, two algorithms, both based on the Taylor series expansion of the coefficient of light attenuation by tissues, are proposed. The results of a clinical study of the proposed approach on volunteers were obtained, allowing to draw a conclusion about the applicability of the approach in a clinical setting.
- ПубликацияТолько метаданныеEvaluating the dynamics of brain tissue oxygenation using near-infrared spectroscopy on various experimental models(2019) Kustov, D. M.; Sharova, A. S.; Makarov, V. I.; Borodkin, A. V.; Savelieva, T. A.; Loschenov, V. B.; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович© 2019 Astro Ltd.In this paper we consider a method for researching the dynamics of blood flow in the cerebral cortex, on an optical phantom that reproduces the parameters of real human and mice brain structures, through the use of near and infrared ranges of laser radiation. For the investigation of real tissue we chose a laboratory mouse brain in vivo. An algorithm for non-invasive diagnostics of the degree of oxygenation was identified and optimal parameters of installation components were selected for taking information about hemodynamic indicators. Output was verified by the reference method for assessing oxygenation by degree of absorption of hemoglobin in the visible range, which indicates that data have a high correlation with classical methods. With further development, this algorithm can be used in various areas of research and diagnostics.
- ПубликацияОткрытый доступCombined video analysis of ICG and 5-ALA induced protoporphyrin IX and hemoglobin oxygen saturation in near infrared(2019) Kustov, D. M.; Makarov, V. I.; Osipova, E. E.; Savelieva, T. A.; Grachev, P. V.; Loschenov, V. B.; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович© 2019 by SCITEPRESS - Science and Technology Publications, Lda. All rights reserved Due to the high recurrence rate after the glial brain tumor removal, methods of intraoperative navigation have a high relevance, providing the most complete removal of tumor tissues with maximum preservation of healthy ones. In this work a combined visualization method is proposed with an assessment of fluorescence and diffuse reflectance images. Fluorescence intensity of 5-ALA-induced protoporphyrin IX allows visualization of tumor cells, distribution of indocyanine green fluorescence helps to visualize the vascular system of the tumor, and parallel mapping of the degree of oxygenation demonstrate the hypoxic regions. The images were obtained in the near infrared range of the optical spectrum in order to maximize the optical probing depth in the window of biological transparency.
- ПубликацияТолько метаданныеOptical Spectral Approach to Breast Tissue Oxygen Saturation Analysis for Mastectomy Perioperative Control(2022) Kustov, D. M.; Krivetskaya, A. A.; Savelieva, T. A.; Loschenov, V. B.; Кривецкая, Анна Александровна; Савельева, Татьяна Александровна; Лощенов, Виктор БорисовичThe purpose of our research is to study the ability of the developed method of hemoglobin detection, based on the fiber-optic spectral analysis in visible region, to determine the level of blood supply to breast tissues before surgical treatment, intraoperatively and during observation of the patient in the postoperative period, when breast tissue is healing. The significant effect of subcutaneous adipose tissue on the shape of diffuse reflectance spectra due to scattering leads to a decrease in the accuracy of determining hemoglobin oxygen saturation and hemoglobin concentration from them. The variability of the subcutaneous adipose tissue layer is quite high, which also leads to a high variability of the spectra within a class of tissues that are in the same physiological state, which implies that the intraclass variability due to this factor should be assessed for a specific problem, not considering it random. For this purpose, in our work, we constructed optical phantoms simulating various thicknesses of the subcutaneous adipose tissue in order to determine the effect of its light scattering on the diffuse reflectance spectrum and to select the optimal configuration of optical fibers. © 2022 by the authors.
- ПубликацияТолько метаданныеIntraoperative assessment of blood flow during esophageal resection using fluorescence diagnostics and diffuse scattering spectroscopy(2024) Krivetskaya, A. A.; Kustov, D. M.; Savelieva, T. A.; Loschenov, V. B.; Кривецкая, Анна Александровна; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович
- ПубликацияТолько метаданныеEvaluation of tissue blood supply during esophagectomy using fluorescent diagnostics and diffuse scattering spectroscopy in visible region(2024) Krivetskaya, A. A.; Kustov, D. M.; Savelieva, T. A.; Loschenov, V. B.; Кривецкая, Анна Александровна; Савельева, Татьяна Александровна; Лощенов, Виктор БорисовичThe success of the surgical treatment of a tumor or obstruction of the esophagus with subsequent anastomosis application depends on the level of blood supply to the stitched tissues. Intraoperative assessment of blood flow is widely used in medicine and can be used as a diagnostic method that affects the outcome of surgery and reduces the frequency of postoperative complications for the patient. In this work, the assessment of blood supply during esophageal resection operations was carried out using two techniques sequentially: fluorescent diagnostics with indocyanine green and measurement of hemoglobin oxygen saturation by diffuse scattering spectroscopy in the visible wavelength range. The first method was used to assess the integrity of the vascular network structure in the area of anastomosis and blood flow through the sutured tissues, the second one – for local assessment of hemoglobin oxygen saturation in the investigated area. Conducted clinical study involved the participation of nine patients with malignant neoplasms (six cases) or esophageal obstruction (three cases). The presence of postoperative complications was compared with the measurement results. Anastomosis failure was observed in only one patient. According to the results of the study, with the use of the investigated method of assessing blood supply, there is a tendency towards a decrease in the frequency of anastomosis leaks (11.1 % compared with 21.4 %). Therefore, fluorescent diagnostics with indocyanine green and measurement of hemoglobin oxygen saturation using diffuse scattering spectroscopy were affirmed as methods that allow increasing the safety of surgical procedures by assessing the risk of postoperative complications, including anastomosis failures.