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Тимашев, Сергей Федорович

Организационные подразделения

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Институт нанотехнологий в электронике, спинтронике и фотонике

Институт ИНТЭЛ занимается научной деятельностью и подготовкой специалистов в области исследования физических принципов, проектирования и разработки технологий создания компонентной базы электроники гражданского и специального назначения, а также построения современных приборов на её основе. Наша основная цель – это создание и развитие научно-образовательного центра мирового уровня в области наноструктурных материалов и устройств электроники, спинтроники, фотоники, а также создание эффективной инновационной среды в области СВЧ-электронной и радиационно-стойкой компонентной базы, источников ТГц излучения, ионно-кластерных технологий материалов.

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Тимашев

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Сергей Федорович

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Теперь показываю 1 - 10 из 15

Только метаданные
Non-Nucleon Metastable Excitations in Nuclear Matter and e– Catalysis As a Quark-Cumulative Mechanism for Initiating Low-Energy Nuclear Chemical Processes: Phenomenology
(2024) Timashev, S. F.; Тимашев, Сергей Федорович
Только метаданные
Stem cell therapy for vocal fold regeneration after scarring: a review of experimental approaches
(2022) Svistushkin, M. V.; Kotova, S.; Shpichka, A.; Starostina, S.; Timashev, S.; Тимашев, Сергей Федорович
© 2022, The Author(s).This review aims at becoming a guide which will help to plan the experimental design and to choose adequate methods to assess the outcomes when testing cell-based products in the treatment of the damaged vocal folds. The requirements to preclinical trials of cell-based products remain rather hazy and dictated by the country regulations. Most parameters like the way the cells are administered, selection of the cell source, selection of a carrier, and design of in vivo studies are decided upon by each research team and may differ essentially between studies. The review covers the methodological aspects of preclinical studies such as experimental models, characterization of cell products, assessment of the study outcome using molecular, morphological and immunohistochemical analyses, as well as measuring the tissue physical properties. The unified recommendations to perform preclinical trials could significantly facilitate the translation of cell-based products into the clinical practice. Graphical abstract: [Figure not available: see fulltext.]
Только метаданные
FNS-Parameterization of Irregularities of Solar Activity Dynamic Variables
(2023) Demin, S. A.; Yunusov, V. A.; Timashev, S. F.; Minkin, A. V.; Тимашев, Сергей Федорович
Только метаданные
Collagen fibrillar structures in vocal fold scarring and repair using stem cell therapy: a detailed histological, immunohistochemical and atomic force microscopy study
(2019) Svistushkin, M. V.; Kotova, S. L.; Shekhter, A. B.; Svistushkin, V. M.; Timashev, S. F.; Тимашев, Сергей Федорович
© 2019 The Authors Journal of Microscopy © 2019 Royal Microscopical Society Regenerative medicine opens new opportunities in the repair of cicatricial lesions of the vocal folds. Here, we present a thorough morphological study, with the focus on the collagen structures in the mucosa of the vocal folds, dedicated to the effects of stem cells on the vocal folds repair after cicatricial lesions. We used a conventional experimental model of a mature scar of the rabbit vocal folds, which was surgically excised with a simultaneous implantation of autologous bone marrow-derived mesenchymal stem cells (MSC) into the defect. The restoration of the vocal folds was studied 3 months postimplantation of stem cells and 6 months after the first surgery. The collagen structure assessment included histology, immunohistochemistry and atomic force microscopy (AFM) studies. According to the data of optical microscopy and AFM, as well as to immunohistochemical analysis, MSC implantation into the vocal fold defect leads not only to the general reduction of scarring, normal ratio of collagens type I and type III, but also to a more complete restoration of architecture and ultrastructure of collagen fibres in the mucosa, as compared to the control. The collagen structures in the scar tissue in the vocal folds with implanted MSC are more similar to those in the normal mucosa of the vocal folds than to those of the untreated scars. AFM has proven to be an instrumental technique in the assessment of the ultrastructure restoration in such studies. Lay Description: Regenerative medicine opens new opportunities in the repair of the vocal fold scars. Because collagen is a main component in the vocal fold mucosa responsible for the scar formation and repair, we focus on the collagen structures in the mucosa of the vocal folds, using a thorough morphological study based on histology and atomic force microscopy (AFM). Atomic force microscopy is a scanning microscopic technique which allows revealing the internal structure of a tissue with a resolution up to nanometres. We used a conventional experimental model of a mature scar of the rabbit vocal folds, surgically excised and treated with a mesenchymal stem cells transplant. Our morphological study, primarily AFM, explicitly shows that the collagen structures in the scarred vocal folds almost completely restore after the stem cell treatment. Thus, the modern microscopic methods, and especially AFM are instrumental tools for monitoring the repair of the vocal folds scars.
Только метаданные
Resolving the Paradox of the Dirac Equation through Phenomenology
(2024) Timashev, S. F.; Тимашев, Сергей Федорович
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The Development of Methods for Multiparametric Functional States Analysis of a Human under Conditionsof Preflight Training and Space
(2023) Demin, S.; Panischev, O.; Yunusov, V.; Timashev, S.; Тимашев, Сергей Федорович
Только метаданные
Atom As an Open Dissipative System in the Basic Environment–the Electromagnetic Component of a Physical Vacuum: Phenomenology
(2022) Timashev, S. F.; Тимашев, Сергей Федорович
Abstract: Based on ideas developed by the author about the vacuum of an electromagnetic field (the EM vacuum as a basic system of reference and the Casimir polarization of the EM vacuum near electrons and atomic nuclei) it is shown that the genesis of the irreversibility of real processes in time—the “arrow of time”, as one of the “great problems of modern physics” (according to V.L. Ginzburg)—lies in the inevitability of dissipative processes at all spatiotemporal levels of the hierarchy of natural systems. Dissipation accompanies all processes, from macroscopic—in the dynamics of which irregularities of a chaotic nature inevitably appear—to those at the level of atoms and atomic nuclei, since energy must be supplied from the EM vacuum even to maintain the functionally active state of the electronic subsystem of the atom and the nuclear matter of the atomic nucleus. This occurs in the non-equivalent exchange of energy between the virtual photons of the EM vacuum and the region of the Casimir polarization of the electronic subsystem of an atom or atomic nucleus. Within such representations, the Universe itself is an open system fed with energy from the energy-saturated world environment—the proto-vacuum. Phenomenological ideas about the dynamics of the Universe that are developed in this work allow us to solve the most acute problems of such dynamics in a natural way, along with that of the so-called cosmological constant, and to establish the relationship between this constant, which characterizes the expansion of the Universe, and the energy density of the EM vacuum. The introduced concepts allow us to understand a number of other unsolved problems connected in one way or another with the key role of virtual photons in a number of optical phenomena. This is true in particular for the mysterious phenomenon of no light scattering from distant stellar sources, manifested most clearly in the fixed independence of the surface brightness of similar galaxies from their redshifts, which cannot be understood on the basis of the Huygens–Fresnel principle. It has also been shown that the recently established effect of “mass being attracted by a light flux” is due to the accumulated energy of virtual photons produced by the intense light flux in the near-surface regions of massive objects. The subsequent re-emission of light can in this case determine the so-called lensing effect observed in astrophysics, which is usually considered as associated with the effect gravity has on light fluxes. © 2022, Pleiades Publishing, Ltd.
Только метаданные
Development of a new approach to data analysis of complex systems: Study of synchronization in the dynamics of solar activity parameters
(2021) Yunusov, V. A.; Demin, S. A.; Demina, N. Y.; Timashev, S. F.; Тимашев, Сергей Федорович
© 2021 IEEE.In this paper, we develop a new approach to the study of matching and mismatching effects in simultaneously recorded time signals characterizing the evolution of natural systems. We discuss the challenges of developing methods of intellectual data analysis of data generated by complex composite objects. In the framework of basic provisions and concepts of Flicker-Noise Spectroscopy, we study the frequency-phase synchronization in the dynamics of Wolf numbers and coronal solar ejections. The evolution of collective processes in the solar atmosphere is represented by changes in the shape of the cross-correlators. We calculated the quantitative structural parameters of cross-correlators to assess causal relationships between the parameters of solar activity. The established levels of cross-correlations in thermodynamically open distributed systems, such as the Sun, can become an object of standardization. The combination of Flicker-Noise Spectroscopy with mathematical models and machine learning software will allow advancing in understanding the collective phenomena realized in complex systems.
Только метаданные
The Phenomenon of Artificial Radioactivity in Metal Cathodes under Glow Discharge Conditions
(2022) Timashev, S. F.; Savvatimova, I. B.; Poteshin, S. S.; Kargin, N. I.; Sysoev, A. A.; Ryndya, S. M.; Тимашев, Сергей Федорович; Савватимова, Ирина Борисовна; Потешин, Сергей Станиславович; Каргин, Николай Иванович; Сысоев, Алексей Александрович; Рындя, Сергей Михайлович
© 2022, Pleiades Publishing, Ltd.Abstract: It is shown that artificial radioactivity can be initiated under conditions of a glow-discharge plasma. When analyzing the isotopic and elemental composition in the near-surface region of Pd and Ni cathodes, initial and those treated for 40 hours under conditions of deuterium- or protium-containing plasma, changes were detected, respectively, in the isotopic ratios of Pt and Pb impurity isotopes in the Pd cathode and of Fe, Cu, and Znin the Ni cathode, as well as a significant reduction in the amount of these impurity elements in the cathodes and the formation of W isotopes in the Pd cathode. Possible nuclear processes that cause the established artificial radioactivity are considered.
Только метаданные
Flicker-Noise Spectroscopy analysis of magnetoencephalogram signals in diagnosis and treatment of photosensitive epilepsy
(2022) Demin, S. A.; Yunusov, V. A.; Timashev, S. F.; Тимашев, Сергей Федорович
© 2022 SPIE.Our study demonstrates the potential of Flicker-Noise Spectroscopy analysis of neuromagnetic brain responses (magnetoencephalograms) in possible diagnosis and estimating the effectiveness of treatment of photosensitive epilepsy. The tendency of the organism to restore the synchronization to its normal levels is considered the cornerstone of the analysis. A two-parameter Flicker-Noise Spectroscopy cross-correlation function is applied to show that the breakdown of frequency-phase synchronization in the magnetoencephalograms of the patient can be associated with two distinct mechanisms: high-frequency resonances (50-100 Hz) at specific brain areas and changes in high-frequency stochastic components for other brain areas. Our analysis also reveals a certain disruption of regular behavior and occurrence of asymmetry in three-dimensional plots of the cross-correlation function for some healthy controls, suggesting that these individuals may be susceptible to photosensitive epilepsy. We believe that a similar cross-correlation analysis based on appropriate biomedical signals may be used to assess the effectiveness of medical treatment for other diseases and conditions.