Персона: Григорьева, Мария Сергеевна
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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- ПубликацияТолько метаданныеDigital Microscopy Technologies: A Method for Constructing Incision Lines on Cell Conglomerate Images(2020) Tupitsyn, N. N.; Palladina, A. D.; Nikitaev, V. G.; Pronichev, A. N.; Dmitrieva, V. V.; Polyakov, E. V.; Samsonova, A. D.; Grigoryeva, M. S.; Druzhinina, E. A.; Никитаев, Валентин Григорьевич; Проничев, Александр Николаевич; Дмитриева, Валентина Викторовна; Поляков, Евгений Валерьевич; Григорьева, Мария Сергеевна© 2020, Allerton Press, Inc.Abstract: The article is devoted to the technology of separating conglomerates of leukocyte cells in digital microscopy images of bone marrow preparations in the light range for determining the number of cells and automatic diagnosing. A special feature of the proposed method is the use of the principle of separating cell conglomerates based on abnormal points. The key points of the method: the determination of the cell conglomerate contour, the detection of abnormal points, and sectioning the cell conglomerate image by the bisector of the angle whose vertex is the abnormal point. The parameters providing necessary accuracy of cell conglomerate separation are determined. Here the accuracy is understood as a fraction of correctly separated cells in the images of bone marrow preparations with respect to the total number of cells in the images used in the experiment. Images containing cell conglomerates forming chains were considered. The experiment confirmed the efficiency of the proposed method. The separation accuracy of adjacent cells is 95%.
- ПубликацияТолько метаданныеRadiofrequency Heating of Nanoparticles for Biomedical Applications(2021) Grigoriev, A. A.; Grigoryeva, M. S.; Kargina, Y. V.; Kharin, A. Y.; Zavestovskaya, I. N.; Kanavin, A. P.; Timoshenko, V. Y.; Григорьев, Андрей Андреевич; Григорьева, Мария Сергеевна; Завестовская, Ирина Николаевна; Канавин, Андрей Павлович; Тимошенко, Виктор Юрьевич© 2021, Allerton Press, Inc.Abstract: The heat release during electromagnetic high-frequency (HF) heating of solid-state nanoparticle (NP) suspensions in an electrolyte with physiological solution conductivity is studied. It is shown that heating of a colloidal NP solution in an electrolyte should be calculated taken into account the contribution of an electric double layer formed near the NP surface, and the heating efficiency is controlled by the NP conductivity and the ratio of the frequency of radio-frequency radiation and the electrolyte conductivity. The optimal conductivity of silicon-based NPs for hyperthermia is determined as a function of the HF radiation frequency.
- ПубликацияТолько метаданныеEXPERIMENTAL INVESTIGATION OF THE EFFECT OF UVA RADIATION ON THE CORONAVIRUS INFECTIVE PROPERTIES(2021) Guschin, V. A.; Nikiforova, M. A.; Siniavin, A. E.; Russu, L. I.; Zavestovskaya, I. N.; Fronya, A. A.; Grigoryeva, M. S.; Завестовская, Ирина Николаевна; Фроня, Анастасия Андреевна; Григорьева, Мария Сергеевна© 2021, Allerton Press, Inc.Abstract: The results of experimental studies of the effect of ultraviolet radiation in the UVA wavelength range safe for humans on the β-coronavirus infective properties are presented. Bovine coronavirus not pathogenic for humans is selected as a prototype of the COVID-19 (SARS-CoV-2) pathogenic agent. LEDs with wavelengths of 371 nm and 401 nm are used as a radiation source. It is shown that a dose-dependent decrease in the virus infectious titer is observed for both UVA wavelengths.
- ПубликацияТолько метаданныеANALYSIS OF BIOLOGICAL OBJECTS BY DIGITAL OPTICAL MICROSCOPY USING NEURAL NETWORKS(2021) Tupitsyn, N. N.; Paladina, A. D.; Nikitaev, V. G.; Pronichev, A. N.; Dmitrieva, V. V.; Polyakov, E. V.; Liberis, K. A.; Grigorieva, M. S.; Никитаев, Валентин Григорьевич; Проничев, Александр Николаевич; Дмитриева, Валентина Викторовна; Поляков, Евгений Валерьевич; Григорьева, Мария Сергеевна© 2021, Allerton Press, Inc.Abstract: An interdisciplinary (physics, biology, medicine, computer science) problem of recognizing bone marrow cells for the diagnosis of acute leukemia and minimal residual disease is considered. The use of neural networks for determining cell classes in a microscopic image of a bone marrow preparation is considered. Images are formed in transmitted light. The structure of the neural network and image sample for experimental studies are presented. The structure of the neural network is refined based on the experimental results. The accuracy characteristics of the developed system are determined.
- ПубликацияТолько метаданныеNovel advanced nanotechnologies for nuclear medicine(2021) Zavestovskaya, I. N.; Grigorieva, M.; Deyev, S. M.; Kabashin, A. V.; Завестовская, Ирина Николаевна; Григорьева, Мария Сергеевна; Деев, Сергей Михайлович; Кабашин, Андрей ВикторовичAbstract Nuclear nanomedicine forms a new research field based on the synergy of nuclear medicine and nanotechnology and implying the use of nanomaterials as carriers of diagnostic or therapeutic radionuclides. Such an approach promises a series of advantages over classical methods of nuclear medicine, including an increased surface area-to-volume ratio, passive/active delivery, high loading capacity, large cross-section in interactions with biological tissues, and unique properties of nanomaterials that make possible many functionalities within one construct. In this short review article, we will highlight our recent achievements in the development of nuclear nanomedicine technologies, which promise the advancement of methods for cancer treatment.
- ПубликацияТолько метаданныеSpectral Dependence of Bovine Coronavirus Photoinactivation under Irradiation by UV-A, UV-B, and UV-C Light-Emitting Diodes(2024) Zavestovskaya,I.N.; Fronya,A.A.; Tupitsyn,I.M.; Cheshev,E.A.; Grigor’eva,M.S.; Mavreshko,E.I.; Завестовская, Ирина Николаевна; Фроня, Анастасия Андреевна; Чешев, Евгений Анатольевич; Григорьева, Мария Сергеевна; Маврешко, Егор Игоревич
- ПубликацияТолько метаданныеInactivation of coronaviruses under irradiation by UVA-range light-emitting diodes(2022) Gushchin, V. A.; Russu, L. I.; Cheshev, E. A.; Koromyslov, A. L.; Zavestovskaya, I. N.; Fronya, A. A.; Grigor'eva, M. S.; Завестовская, Ирина Николаевна; Фроня, Анастасия Андреевна; Григорьева, Мария Сергеевна© 2022 Kvantovaya Elektronika and IOP Publishing Limited.We report the results of the development of an experimental stand based on UVA light-emitting diodes (UVA LEDs) with radiation wavelengths of 385 and 395 nm for studying experimentally the inactivation of viruses of the coronavirus family, including SARS-CoV-2. Methodological grounds are presented for determining the inactivation dose that provides a predetermined decrease in the virus titre under the impact of UVA radiation. The effect of the diode radiation divergence on the virus photoinactivation process is investigated. It is shown that UVA LEDs can be used to reduce the virus titre by 4 orders of magnitude.
- ПубликацияОткрытый доступСпектральная зависимость фотоинактивации бычьего коронавируса излучением UV-A, UV-B и UV-C cветодиодов(2024) Завестовская, И. Н.; Фроня, А. А.; Тупицын, И. М.; Гущин, В. А.; Синявин, А. Э.; Руссу, Л. И.; Чешев, Е. А.; Коромыслов, А. Л.; Григорьева, М. С.; Маврешко, Е. И.; Маврешко, Егор Игоревич; Завестовская, Ирина Николаевна; Григорьева, Мария Сергеевна; Фроня, Анастасия Андреевна; Чешев, Евгений АнатольевичПредставлены результаты экспериментальных исследований по воздействию ультрафиолетового (UV) излучения в широком спектральном диапазоне 270 – 405 нм на бычий коронавирус. Определена чувствительность бычьего коронавируса к UV излучению, проведен сравнительный анализ данных, построены спектры действия. Показано, что в диапазоне UV-A возможна инактивации бычьего коронавируса, что позволит подобрать безопасные источники излучения для использования в общественных местах в присутствии человека
- ПубликацияТолько метаданныеEffect of silicon target porosity on laser ablation threshold: molecular dynamics simulation(2021) Kharin, A. Y.; Grigoryeva, M. S.; Zavestovskaya, I. N.; Timoshenko, V. Y.; Григорьева, Мария Сергеевна; Завестовская, Ирина Николаевна; Тимошенко, Виктор ЮрьевичAblation of a porous silicon target under irradiation with ultrashort laser pulse is simulated by means of the molecular dynamics approach. The number of ablated atoms is calculated for targets with different porosity under irradiation with wavelengths in ultraviolet (UV) and visible spectral ranges, which correspond to stronger and weaker absorption coefficient, respectively. An increase of the porosity to 80% leads to 1.5-3 times decrease of the ablation threshold compared to the bulk silicon, while a decrease of pores size from 2.5 to 1.2 nm leads to the stronger ablation threshold drop and the effect is stronger for the UV irradiation. The results are useful for laser processing of silicon-based targets and nanofabrication.
- ПубликацияТолько метаданныеMeasurement of silicon nanoparticles temperature by raman spectroscopy(2021) Alykova, A. F.; Grigoryeva, M. S.; Zavestovskaya, I. N.; Timoshenko, V. Yu.; Григорьева, Мария Сергеевна; Завестовская, Ирина Николаевна; Тимошенко, Виктор Юрьевич© 2021 Journal of Biomedical Photonics & Engineering.The temperature of silicon nanoparticles under laser photo-induced heating is determined from the ratio of the intensities of the Stokes and anti-Stokes components of the Raman scattering. The obtained results of the dependence of nanoparticles temperature on the laser radiation intensity and the temperature dependence of the Raman line position may be used to determine the optimal regimes of photo-hyperthermia enhanced by silicon nanoparticles for cancer therapy.