Персона: Блинова, Екатерина Валериевна
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Блинова
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Екатерина Валериевна
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- ПубликацияОткрытый доступAn effective way for targeting EGFR-mediated carcinogenesis: an in vitro study(2024) Pakina, V. A.; Epishkina, A. A.; Grebenkin, E. V.; Blinova, E. V.; Епишкина, Анна Алексеевна; Гребенкин, Евгений Валерьевич; Блинова, Екатерина ВалериевнаIntroduction: EGFR-activating overexpression or somatic mutations are common in different human cancers. In this regard, the search for promising ways to control the carcinogenic transformation of tumor cells and the progression of malignant tumors expressing EGFR seems to be one of the most promising and developing areas of modern molecular pathology and pharmacology. Material and Methods: An antitumor activity of a novel compound, a pyridine carboxylic acid derivative LHT-17-19, was studied. The molecule was developed and synthesized at the Department of Chemistry, Drug Design and Technology of All-Russian Research Center for Biological Active Compounds Safety (Russia). The study was carried out in cell cultures of stomach cancer (Hs746T, AGS and MKN1) and patient-derived organoid (PDO) model of breast cancer (BC) expressing wild-type EGFR. Results: It was shown that LHT-17-19 induced concentration-dependent cytotoxicity of EGFR-expressing gastric cancer cells of all the aforementioned cultures. Pathomorphological, immunohistochemical and molecular validation of BC organoids derived from ductal breast carcinoma cells of a 68-year-old patient was done. PDOs were established as ER-negative, PR-negative, Her2/neu-negative, EGFR-positive with 35% of the Ki-67 expression index. In addition, the tumor cells translocation was resulted in a loss of ER expression and PDOs molecular pattern conversion towards a more aggressive triple negative type. PDOs incubation with 0.5-60.0 ‚?M LHT-17-19 was accompanied not only by inhibition of their growth and proliferation, but also by significant cytoreduction. Conclusion: Thus, in two-dimensional and three-dimensional tumor cell cultures, the possibility of controlling the oncogenic expression of EGFR with the acridone compound 9-ammonium-3,3-dimethyl-3,4-dihydroacridine-1(2H)-OH L-2-hydroxybutanedivacate (LHT-17-19) was shown.
- ПубликацияТолько метаданныеAntitumor activity of aminochromene derivative on the human-derived lung adenocarcinoma xenograft model in BALB/C nu/nu mice IÐIOEAIIIOOIEAAIA AAENOAEA IÐIECAIAIIAI AIEIIOÐIIAIA IA IIAAEE ENAIIAÐAOOA AAAIIEAÐOEIIIU EAAEIAI O IUØAE nu/nu BALB(2021) Dudina, M. O.; Blinov, D. S.; Suslova, I. R.; Skachilova, S. Ya.; Blinova, E. V.; Блинова, Екатерина Валериевна© 2021 Izdatel'stvo Meditsina. All rights reserved.The antitumor and anti-metastatic effects of aminochromene derivative AKh-554 upon intragastric administration were studied on immunodeficient BALB/c nu/nu female mice with heterotopic human-derived lung adenocarcinoma xenograft model. In the tumor tissue of animals treated with the test compound, the levels of TUBB3, ALK and c-MET/HFG oncomarkers were quantitatively detected and it was found that the drug suppressed the velocity of tumor growth and its size as well as exhibited anti-metastatic activity. AKh-554 produced 3.3-fold increase in tumor carriers survival and induced stable remission in 60% of test mice (p 0.001). The effect might be due to anti-ALK-dependent activation of apoptosis of tumor cells and suppression of cell proliferation. The results were obtained on the tumor system without signs of pharmacoresistance to AX-554, which was confirmed by the lack of dynamics of c-MET/HFG in tumor tissue in all test groups.
- ПубликацияТолько метаданные3-HYDROXYPYRIDINE DERIVATIVE WITH ASCORBIC ACID RESIDUE INCREASES SURVIVAL OF CEREBRAL CORTEX CELLS UNDER CONDITIONS OF EXPERIMENTAL ISCHEMIA IÐIECAIAIIA 3-AEAÐIENEIEÐEAEIA N INOAOEII ANEIÐAEIIAIE EENEIOU IIAUØAAO AUÆEAAAIINOU EEAOIE AIEIAIIAI IICAA A ONEIAEßO YENIAÐEIAIOAEUIIE EØAIEE(2023) Blinova, E. V.; Timoshkin, D. E.; Belanov, K. Y.; Vasilkina, O. V.; Блинова, Екатерина Валериевна
- ПубликацияТолько метаданныеBuccal fat pad’ buccal flap anatomical variation(2023) Mirontsev, A. V.; Kolesova, L. Yu.; Vasil’ev, Yu. L.; Blinova, E. V.; Миронцев, Артём Владимирович; Блинова, Екатерина Валериевна
- ПубликацияТолько метаданныеClinical and experimental rationale for using phenylephrine with hypromellose for the treatment of extra accommodation strain in patients with myopia(2023) Makhova, M. V.; Shikh, E. V.; Strakhov, V. V.; Blinova, E. V.; Blinov, D. S.; Блинова, Екатерина Валериевна
- ПубликацияТолько метаданныеModification and Validation of a Laboratory Method for Determination of L-Asparaginase Activity in Patient Blood Serum(2023) Osipiantz, A. I.; Shikalov, A. B.; Tumutolova, O. M.; Karachunsky, A. I.; Blinova, E. V.; Блинова, Екатерина Валериевна
- ПубликацияОткрытый доступClinical anatomy features of the buccal part of the facial vein Особенности клиническои анатомии лицевои вены в щечнои области(2023) Mirontsev, A. V.; Vasil’ev, Yu. L.; Kolesova, L. Yu.; Zhandarov, K. A.; Blinova, E. V.; Миронцев, Артём Владимирович; Блинова, Екатерина Валериевна
- ПубликацияТолько метаданныеSynthesis and In Silico Prediction of the Molecular-Targeting Anti-EGFR Action of a Novel Dihydroacridinone(2024) Epishkina, A. A.; Bogoslovskaya, E. V.; Pakina, V. A.; Blinova, E. V.; Епишкина, Анна Алексеевна; Блинова, Екатерина Валериевна