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Developing mathematical method for multi alignment of DNA sequences with weak similarity

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dc.contributor.authorKorotkov, E. V.
dc.contributor.authorKorotkova, M. A.
dc.contributor.authorКоротков, Евгений Вадимович
dc.contributor.authorКороткова, Мария Александровна
dc.date.accessioned2024-11-21T09:11:42Z
dc.date.available2024-11-21T09:11:42Z
dc.date.issued2019
dc.description.abstract© 2019 Published under licence by IOP Publishing Ltd.A new mathematical method is proposed for constructing multiple alignment of weakly similar amino acid or nucleotide sequences. The method uses a multiple alignment representation in the form of position-weight matrices (PWM) and global dynamic programming. An optimization procedure for PWM is developed with the aim of finding a multiple alignment with maximum statistical significance. The method allows to find multiple alignment of sequences with the number of nucleotide or amino acid substitutions more than 2.5. The developed approach is applied to obtain multiple alignment of promoter sequences of 600 DNA bases length.
dc.identifier.citationKorotkov, E. V. Developing mathematical method for multi alignment of DNA sequences with weak similarity / Korotkov, E.V., Korotkova, M.A. // Journal of Physics: Conference Series. - 2019. - 1205. - № 1. - 10.1088/1742-6596/1205/1/012025
dc.identifier.doi10.1088/1742-6596/1205/1/012025
dc.identifier.urihttps://www.doi.org/10.1088/1742-6596/1205/1/012025
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85066314194&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000481606200025
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/18168
dc.relation.ispartofJournal of Physics: Conference Series
dc.titleDeveloping mathematical method for multi alignment of DNA sequences with weak similarity
dc.typeConference Paper
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume1205
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