Publication: Laser-induced fluorescent diagnostics and photodynamic therapy of cervical neoplasms
Дата
2020
Авторы
Shiryaev, A. A.
Amirkhanova, L. M.
Linkov, K. G.
Alekseeva, P. M.
Efendiev, K. T.
Loschenov, V. B.
Journal Title
Journal ISSN
Volume Title
Издатель
Аннотация
© 2020 IEEE.The paper presents the results of precise fluorescent diagnostics of cervical neoplasms at photodynamic therapy using a photosensitizer, chlorin e6 (Photolon). The precise fluorescent diagnostics supposes the combined use of spectral and video fluorescent diagnostics of pathological and normal tissues. A fiber spectrometer with excitation of the photosensitizer fluorescence by a He-Ne laser (? = 632.8 nm) and a semiconductor laser (? = 660 nm) was used for spectral fluorescent diagnostics. A two-channel fluorescent video system was used for video fluorescent diagnostics. The results of spectral diagnostics showed that the chlorin e6 accumulation level in pathological tissues is 4- 8 times higher than in normal tissues. The fluorescent images of cervical neoplasms at the applied dose of the photosensitizer had high contrast compared to normal tissues. The results of spectral fluorescent diagnostics well correlate with the results of video fluorescent diagnostics. Photodynamic therapy was performed using the semiconductor laser (? = 660 nm, E = 100-200 J/cm2) 3 hours after a drip intravenous administration of the photosensitizer and was controlled via photobleaching.
Описание
Ключевые слова
Цитирование
Laser-induced fluorescent diagnostics and photodynamic therapy of cervical neoplasms / Shiryaev, A.A. [et al.] // Proceedings - International Conference Laser Optics 2020, ICLO 2020. - 2020. - 10.1109/ICLO48556.2020.9285518
URI
https://www.doi.org/10.1109/ICLO48556.2020.9285518
https://www.scopus.com/record/display.uri?eid=2-s2.0-85099375359&origin=resultslist
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000685170600129
https://openrepository.mephi.ru/handle/123456789/23037
https://www.scopus.com/record/display.uri?eid=2-s2.0-85099375359&origin=resultslist
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000685170600129
https://openrepository.mephi.ru/handle/123456789/23037