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Technetium(I) carbonyl complexes for nuclear medicine: Coordination-chemical aspect

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dc.contributor.authorSidorenko, G. V.
dc.contributor.authorMiroslavov, A. E.
dc.contributor.authorTyupina, M. Y.
dc.date.accessioned2024-12-28T07:59:25Z
dc.date.available2024-12-28T07:59:25Z
dc.date.issued2023
dc.description.abstractStudies concerning the development of radiopharmaceuticals based on the Tc(I) carbonyl core are considered from the coordination-chemical viewpoint. The coordination behavior of the fac-Tc(CO)3+ core (hard/soft acid properties, complexation kinetics and thermodynamics, coordination preferences, mutual influence of ligands) is discussed in detail. Particular attention is paid to possible coordination isomerism and stereoisomerism of the complexes—problems that often escape from researchers’ attention. Metal-mediated ligand transformations, which can play both positive and negative role in the synthesis, are summarized for the first time. A comparative analysis of possible labeling strategies (one-pot, prelabeling, postlabeling) is made with more detailed consideration of the click-to-chelate and chelate-then-click approaches. A summary of ligands and ligand systems used for tethering the fac-Tc(CO)3+ core to biomolecules is made, including typical complexation conditions, yields, and key characteristics of the bioconjugate stability. Alternative technetium carbonyl coordination cores (higher carbonyls, mer-Tc(CO)3+, Tc(CO)2(NO)2+, Tc(CO)2(phosphine, isonitrile)2+, Tc(CO)2(isonitrile)4+) are briefly discussed. Coordination-chemical problems deserving, in authors’ opinion, a more detailed study are pointed out. © 2022 Elsevier B.V.
dc.identifier.citationSidorenko, G. V. Technetium(I) carbonyl complexes for nuclear medicine: Coordination-chemical aspect / Sidorenko, G.V., Miroslavov, A.E., Tyupina, M.Y. // Coordination Chemistry Reviews. - 2023. - 476. - 10.1016/j.ccr.2022.214911
dc.identifier.doi10.1016/j.ccr.2022.214911
dc.identifier.urihttps://www.doi.org/10.1016/j.ccr.2022.214911
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85141967329&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000904068000002
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/29858
dc.relation.ispartofCoordination Chemistry Reviews
dc.subjectfac-Tc(CO)3+ core
dc.subjectIsomerism
dc.subjectLabeling strategies
dc.subjectMetal-mediated ligand transformations
dc.subjectTc bioconjugates
dc.subjectTechnetium(I) carbonyl complexes
dc.titleTechnetium(I) carbonyl complexes for nuclear medicine: Coordination-chemical aspect
dc.typeReview
dspace.entity.typePublication
oaire.citation.volume476
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