Publication:
Technetium(I) carbonyl complexes for nuclear medicine: Coordination-chemical aspect

Дата
2023
Авторы
Sidorenko, G. V.
Miroslavov, A. E.
Tyupina, M. Y.
Journal Title
Journal ISSN
Volume Title
Издатель
Научные группы
Организационные подразделения
Выпуск журнала
Аннотация
Studies concerning the development of radiopharmaceuticals based on the Tc(I) carbonyl core are considered from the coordination-chemical viewpoint. The coordination behavior of the fac-Tc(CO)3+ core (hard/soft acid properties, complexation kinetics and thermodynamics, coordination preferences, mutual influence of ligands) is discussed in detail. Particular attention is paid to possible coordination isomerism and stereoisomerism of the complexes—problems that often escape from researchers’ attention. Metal-mediated ligand transformations, which can play both positive and negative role in the synthesis, are summarized for the first time. A comparative analysis of possible labeling strategies (one-pot, prelabeling, postlabeling) is made with more detailed consideration of the click-to-chelate and chelate-then-click approaches. A summary of ligands and ligand systems used for tethering the fac-Tc(CO)3+ core to biomolecules is made, including typical complexation conditions, yields, and key characteristics of the bioconjugate stability. Alternative technetium carbonyl coordination cores (higher carbonyls, mer-Tc(CO)3+, Tc(CO)2(NO)2+, Tc(CO)2(phosphine, isonitrile)2+, Tc(CO)2(isonitrile)4+) are briefly discussed. Coordination-chemical problems deserving, in authors’ opinion, a more detailed study are pointed out. © 2022 Elsevier B.V.
Описание
Ключевые слова
fac-Tc(CO)3+ core , Isomerism , Labeling strategies , Metal-mediated ligand transformations , Tc bioconjugates , Technetium(I) carbonyl complexes
Цитирование
Sidorenko, G. V. Technetium(I) carbonyl complexes for nuclear medicine: Coordination-chemical aspect / Sidorenko, G.V., Miroslavov, A.E., Tyupina, M.Y. // Coordination Chemistry Reviews. - 2023. - 476. - 10.1016/j.ccr.2022.214911
URI
https://www.doi.org/10.1016/j.ccr.2022.214911
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85141967329&origin=resultslist
 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000904068000002
 https://openrepository.mephi.ru/handle/123456789/29858
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