Publication:
Zn-CysHis Protein Factor Families: Role of Electrostatic Interaction of Zn-Domains in Factor Functions

Дата
2020
Авторы
Chirgadze, Y. N.
Ivanov, V. V.
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Научные группы
Организационные подразделения
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Организационная единица
Институт лазерных и плазменных технологий
Стратегическая цель Института ЛаПлаз – стать ведущей научной школой и ядром развития инноваций по лазерным, плазменным, радиационным и ускорительным технологиям, с уникальными образовательными программами, востребованными на российском и мировом рынке образовательных услуг.
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Аннотация
© 2020, Pleiades Publishing, Inc.Abstract—The large amount of the DNA- and RNA-binding protein regulatory factors contain Zn-domains. Total six Zn-CysHis factor families with different functions were considered. Among them the transcription factors of family PF00096, complex type Zn-Cys2His2, is the most important because it includes over 340.000 members of 365.000 total members listed at present in the Zn-containing factor families. The role of electrostatic potential of Zn-domains in the structure and function of factors from different factor families has been considered. We have shown that the positive electrostatic potential of Zn-domains plays an essential role in forming contact of factors’ Zn-domains with DNA/RNA in three protein factor families PF00096, PF12874, and PF09329. While in other three families PF03119, PF08996, and PF01258 Zn-domains do not contact with nucleic acids, and electrostatic interactions do not play a distinctive role, consequently.
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Цитирование
Chirgadze, Y. N. Zn-CysHis Protein Factor Families: Role of Electrostatic Interaction of Zn-Domains in Factor Functions / Chirgadze, Y.N., Ivanov, V.V. // Molecular Biology. - 2020. - 54. - № 2. - P. 157-162. - 10.1134/S002689332002003X
URI
https://www.doi.org/10.1134/S002689332002003X
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85083962910&origin=resultslist
 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000529686000001
 https://openrepository.mephi.ru/handle/123456789/21622
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