Publication: Multiplexed Detection of Cancer Serum Antigens with a Quantum Dot-Based Lab-on-Bead System
Дата
2020
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Аннотация
A quantum dot (QD)-based lab-on-bead system is a unique tool for multiple analysis of cancer markers in human serum samples by using a flow cytometer. In terms of specificity and sensitivity, this method is comparable with ELISA, the "gold standard" of serological in-clinic detection of single analytes. Fluorescent microspheres encoded with QDs have been used for the quantitative detection of free and total prostate-specific antigen in human serum samples. Developed multiplex assay demonstrates a clear discrimination between serum samples from control subjects and cancer patients. The proposed QD-based method is adaptable and makes it possible to develop numerous clinical tests with decreased duration and cost for early diagnosis of various diseases.
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Multiplexed Detection of Cancer Serum Antigens with a Quantum Dot-Based Lab-on-Bead System / Karaulov, A. [et al.] // Methods in Molecular Biology. - 2020. - 2135. - P. 225-236. - 10.1007/978-1-0716-0463-2_13
URI
https://www.doi.org/10.1007/978-1-0716-0463-2_13
https://www.scopus.com/record/display.uri?eid=2-s2.0-85083042198&origin=resultslist
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https://openrepository.mephi.ru/handle/123456789/20603
https://www.scopus.com/record/display.uri?eid=2-s2.0-85083042198&origin=resultslist
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000680965100014
https://openrepository.mephi.ru/handle/123456789/20603