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The influence of carrier addition on the biodistribution of bone-seeking agent 188Re-oxa-bis(ethylenenitrilo)- tetramethylenephosphonic acid

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dc.contributor.authorTishchenko, V. K.
dc.contributor.authorMikhailovskaya, A. A.
dc.contributor.authorSmoryzanova, O. A.
dc.contributor.authorKuzenkova, K. A.
dc.contributor.authorPetriev, V. M.
dc.date.accessioned2024-11-21T08:28:43Z
dc.date.available2024-11-21T08:28:43Z
dc.date.issued2019
dc.description.abstract© 2019 Published under licence by IOP Publishing Ltd. Bone-seeking radiopharmaceuticals are known to be the most promising agents for the palliative treatment of the pain of bone metastases. A generator-produced radionuclide rhenium-188 ( 188 Re) is an attractive candidate for therapeutic use due to its nuclear characteristics. The goal of the current work was the investigation of the biodistribution of 188 Re-oxa-bis(ethylenenitrilo)tetramethylenephosphonic acid ( 188 Re-OENTMP) with gallium carrier and without carrier and to compare them. A comparative accumulation study of both 188 Re-OENTMP formulations was performed in normal rats after intravenous administration up to 48 hours. It was revealed that for carrier-added 188 Re-OENTMP the bone samples from femur, skull, ribs, spine and knee joint all had higher uptake in comparison to that of 188 Re-OENTMP without carrier. The values of carrier-added 188 Re-OENTMP in skeleton were ranged from 7,82% to 57,37% of injected dose (ID), when the amount of 188 Re-OENTMP without carrier varied from 5,76% to 22,75% of ID. Among the soft tissue organs, only thyroid gland and kidneys had a relatively high uptake. Most of the activity excreted via the urinary tract. In conclusion, it should be pointed out that carrier addition strongly affects bone uptake of 188 Re-OENTMP, so carrier-added 188 Re-OENTMP could be useful to deliver radiation to skeletal metastases from soft tissue cancer.
dc.identifier.citationThe influence of carrier addition on the biodistribution of bone-seeking agent 188Re-oxa-bis(ethylenenitrilo)- tetramethylenephosphonic acid / Tishchenko, V.K. [et al.] // Journal of Physics: Conference Series. - 2019. - 1189. - № 1. - 10.1088/1742-6596/1189/1/012044
dc.identifier.doi10.1088/1742-6596/1189/1/012044
dc.identifier.urihttps://www.doi.org/10.1088/1742-6596/1189/1/012044
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85065606664&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/17979
dc.relation.ispartofJournal of Physics: Conference Series
dc.titleThe influence of carrier addition on the biodistribution of bone-seeking agent 188Re-oxa-bis(ethylenenitrilo)- tetramethylenephosphonic acid
dc.typeConference Paper
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume1189
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
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