Publication:
The influence of carrier addition on the biodistribution of bone-seeking agent 188Re-oxa-bis(ethylenenitrilo)- tetramethylenephosphonic acid

Файлы
W2939909478.pdf(1.01 MB)
Дата
2019
Авторы
Tishchenko, V. K.
Mikhailovskaya, A. A.
Smoryzanova, O. A.
Kuzenkova, K. A.
Petriev, V. M.
Journal Title
Journal ISSN
Volume Title
Издатель
Научные группы
Организационные подразделения
OrgUnit Logo
Организационная единица
Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
Выпуск журнала
Аннотация
© 2019 Published under licence by IOP Publishing Ltd. Bone-seeking radiopharmaceuticals are known to be the most promising agents for the palliative treatment of the pain of bone metastases. A generator-produced radionuclide rhenium-188 ( 188 Re) is an attractive candidate for therapeutic use due to its nuclear characteristics. The goal of the current work was the investigation of the biodistribution of 188 Re-oxa-bis(ethylenenitrilo)tetramethylenephosphonic acid ( 188 Re-OENTMP) with gallium carrier and without carrier and to compare them. A comparative accumulation study of both 188 Re-OENTMP formulations was performed in normal rats after intravenous administration up to 48 hours. It was revealed that for carrier-added 188 Re-OENTMP the bone samples from femur, skull, ribs, spine and knee joint all had higher uptake in comparison to that of 188 Re-OENTMP without carrier. The values of carrier-added 188 Re-OENTMP in skeleton were ranged from 7,82% to 57,37% of injected dose (ID), when the amount of 188 Re-OENTMP without carrier varied from 5,76% to 22,75% of ID. Among the soft tissue organs, only thyroid gland and kidneys had a relatively high uptake. Most of the activity excreted via the urinary tract. In conclusion, it should be pointed out that carrier addition strongly affects bone uptake of 188 Re-OENTMP, so carrier-added 188 Re-OENTMP could be useful to deliver radiation to skeletal metastases from soft tissue cancer.
Описание
Ключевые слова
Цитирование
The influence of carrier addition on the biodistribution of bone-seeking agent 188Re-oxa-bis(ethylenenitrilo)- tetramethylenephosphonic acid / Tishchenko, V.K. [et al.] // Journal of Physics: Conference Series. - 2019. - 1189. - № 1. - 10.1088/1742-6596/1189/1/012044
URI
https://www.doi.org/10.1088/1742-6596/1189/1/012044
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85065606664&origin=resultslist
 https://openrepository.mephi.ru/handle/123456789/17979
Коллекции
Публикации