Publication: Combined spectral- and video-fluorescent diagnostics of cervical neoplasms for photodynamic therapy
Дата
2020
Авторы
Alekseeva, P. M.
Efendiev, K. T.
Loshchenov, M. V.
Shiryaev, A. A.
Loschenov, V. B.
Journal Title
Journal ISSN
Volume Title
Издатель
Аннотация
This study aimed to evaluate the method of fluorescence diagnostics using the developed video-fluorescent equipment with laser excitation of fluorescence and the assessment of the effectiveness of photodynamic therapy via the photobleaching of the chlorin e6. The boundaries of precancerous conditions and cervical neoplasms were established using video-fluorescent diagnostics and then clarified using spectral-fluorescent diagnostics. At a photosensitizer dose of 0.8-1.2 mg kg(-1), fluorescence images of the cervix contrasted well in the pathological tissue compared to the normal surrounding tissue. This made it possible to estimate the photosensitizer distribution in the entire measured area with a resolution of at least 1 mm. The parallel use of spectral-fluorescent diagnostics allows the identification of fluorescence typical for the photosensitizer fluorescence and evaluating its distribution in the studied tissues. The combined use of video- and spectral-fluorescent diagnostics for cervical neoplasms allows control of the process of photodynamic therapy at all stages of the procedure and, if it is necessary, a change of tactics.
Описание
Ключевые слова
Цитирование
Combined spectral- and video-fluorescent diagnostics of cervical neoplasms for photodynamic therapy / Alekseeva, PM [et al.] // Laser Physics Letters. - 2020. - 17. - № 10. - 10.1088/1612-202X/abae6a
URI
https://www.doi.org/10.1088/1612-202X/abae6a
https://www.scopus.com/record/display.uri?eid=2-s2.0-85095833176&origin=resultslist
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000571858200001
https://openrepository.mephi.ru/handle/123456789/22392
https://www.scopus.com/record/display.uri?eid=2-s2.0-85095833176&origin=resultslist
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000571858200001
https://openrepository.mephi.ru/handle/123456789/22392