Publication:
Nanoparticle-doped hybrid polyelectrolyte microcapsules with controlled photoluminescence for potential bioimaging applications

Дата
2021
Авторы
Efimov, A.
Korostylev, E.
Zarubin, S.
Karaulov, A.
Nifontova, G.
Krivenkov, V.
Krivenkov,V.
Zvaigzne, M.
Нифонтова, Галина Олеговна
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Научные группы
Организационные подразделения
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Организационная единица
Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Аннотация
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Fluorescent imaging is widely used in the diagnosis and tracking of the distribution, interaction, and transformation processes at molecular, cellular, and tissue levels. To be detectable, delivery systems should exhibit a strong and bright fluorescence. Quantum dots (QDs) are highly photostable fluorescent semiconductor nanocrystals with wide absorption spectra and narrow, size-tunable emission spectra, which make them suitable fluorescent nanolabels to be embedded into microparticles used as bioimaging and theranostic agents. The layer-by-layer deposition approach allows the entrapping of QDs, resulting in bright fluorescent microcapsules with tunable surface charge, size, rigidity, and functional properties. Here, we report on the engineering and validation of the structural and photoluminescent characteristics of nanoparticle-doped hybrid microcapsules assembled by the deposition of alternating oppositely charged polyelectrolytes, water-soluble PE-Gylated core/shell QDs with a cadmium selenide core and a zinc sulfide shell (CdSe/ZnS), and carboxylated magnetic nanoparticles (MNPs) onto calcium carbonate microtemplates. The results demonstrate the efficiency of the layer-by-layer approach to designing QD-, MNP-doped microcap-sules with controlled photoluminescence properties, and pave the way for the further development of next-generation bioimaging agents based on hybrid materials for continuous fluorescence imaging.
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Nanoparticle-doped hybrid polyelectrolyte microcapsules with controlled photoluminescence for potential bioimaging applications / Efimov, A. [et al.] // Polymers. - 2021. - 13. - № 23. - 10.3390/polym13234076
URI
https://www.doi.org/10.3390/polym13234076
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85119997944&origin=resultslist
 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000742669200001
 https://openrepository.mephi.ru/handle/123456789/25031
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