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Ultrabright fluorescent silica nanoparticles for: In vivo targeting of xenografted human tumors and cancer cells in zebrafish

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dc.contributor.authorPeerzade, S. A. M. A.
dc.contributor.authorQin, X.
dc.contributor.authorLaroche, F. J. F.
dc.contributor.authorPalantavida, S.
dc.contributor.authorDokukin, M.
dc.date.accessioned2024-11-21T15:08:33Z
dc.date.available2024-11-21T15:08:33Z
dc.date.issued2019
dc.description.abstract© The Royal Society of Chemistry 2019.New ultrabright fluorescent silica nanoparticles capable of the fast targeting of epithelial tumors in vivo are presented. The as-synthesized folate-functionalized ultrabright particles of 30-40 nm are 230 times brighter than quantum dots (QD450) and 50% brighter than the polymer dots with similar spectra (excitation 365 nm and emission 486 nm). To decrease non-specific targeting, particles are coated with polyethylene glycol (PEG). We demonstrate the in vivo targeting of xenographic human cervical epithelial tumors (HeLa cells) using zebrafish as a model system. The particles target tumors (and probably even individual HeLa cells) as small as 10-20 microns within 20-30 minutes after blood injection. To demonstrate the advantages of ultrabrightness, we repeated the experiments with similar but 200× less bright particles. Compared to those, ultrabright particles showed ∼3× faster tumor detection and ∼2× higher relative fluorescent contrast of tumors/cancer cells.
dc.format.extentС. 22316-22327
dc.identifier.citationUltrabright fluorescent silica nanoparticles for: In vivo targeting of xenografted human tumors and cancer cells in zebrafish / Peerzade, S.A.M.A. [et al.] // Nanoscale. - 2019. - 11. - № 46. - P. 22316-22327. - 10.1039/c9nr06371d
dc.identifier.doi10.1039/c9nr06371d
dc.identifier.urihttps://www.doi.org/10.1039/c9nr06371d
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85075813749&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000507989900019
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/18971
dc.relation.ispartofNanoscale
dc.titleUltrabright fluorescent silica nanoparticles for: In vivo targeting of xenografted human tumors and cancer cells in zebrafish
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue46
oaire.citation.volume11
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