Publication:
Ultrabright fluorescent silica nanoparticles for: In vivo targeting of xenografted human tumors and cancer cells in zebrafish

Дата
2019
Авторы
Peerzade, S. A. M. A.
Qin, X.
Laroche, F. J. F.
Palantavida, S.
Dokukin, M.
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Научные группы
Организационные подразделения
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Аннотация
© The Royal Society of Chemistry 2019.New ultrabright fluorescent silica nanoparticles capable of the fast targeting of epithelial tumors in vivo are presented. The as-synthesized folate-functionalized ultrabright particles of 30-40 nm are 230 times brighter than quantum dots (QD450) and 50% brighter than the polymer dots with similar spectra (excitation 365 nm and emission 486 nm). To decrease non-specific targeting, particles are coated with polyethylene glycol (PEG). We demonstrate the in vivo targeting of xenographic human cervical epithelial tumors (HeLa cells) using zebrafish as a model system. The particles target tumors (and probably even individual HeLa cells) as small as 10-20 microns within 20-30 minutes after blood injection. To demonstrate the advantages of ultrabrightness, we repeated the experiments with similar but 200× less bright particles. Compared to those, ultrabright particles showed ∼3× faster tumor detection and ∼2× higher relative fluorescent contrast of tumors/cancer cells.
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Ultrabright fluorescent silica nanoparticles for: In vivo targeting of xenografted human tumors and cancer cells in zebrafish / Peerzade, S.A.M.A. [et al.] // Nanoscale. - 2019. - 11. - № 46. - P. 22316-22327. - 10.1039/c9nr06371d
URI
https://www.doi.org/10.1039/c9nr06371d
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85075813749&origin=resultslist
 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000507989900019
 https://openrepository.mephi.ru/handle/123456789/18971
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