Publication:
Analysis of the heart rate in a model test organism daphniamagna as a new approach to the assessment of radioecological effects of irradiation

Дата
2020
Авторы
Morozova, A. O.
Kolesnikova, N. I.
Savina, N. B.
Uskalova, D. V.
Sarapultseva, E. I.
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Научные группы
Организационные подразделения
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Организационная единица
Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Аннотация
© 2020 Obninsk Institute for Nuclear Power Engineering, National Research Nuclear University 'MEPhI'. All rights reserved.The purpose of the work was to test the method of low-coherence interference microscopy as a new approach to analyzing the spatio-temporal characteristics of the heart rate in a model test object, Daphniamagna (D.magna), and assessing the radioecological effects of irradiation. As an affecter, acute external gamma irradiation at a dose of 10 Gy was used. D.magna is a semi-transparent crustacean widely used in radiobiology and ecotoxicology. as a key model for analyzing the long-term effects of low doses and concentrations of pollutants. The heart rate of D.magna is mainly studied in screening of pharmaceutical substances at the stage of pre-clinical drug trials. This study showed that the method of low-coherence interferometry is an effective tool for studying the heart rate of D.magna as a physiological stress-exposure function. The heart rate was measured at 2, 10, 14 and 19 days after irradiation simultaneously in the control and experimental groups of D.magna. ANOVA analysis showed a significant effect of time after gamma irradiation on changes in the heart rate of the experimental animals. At the same time, according to our data, the contribution of irradiation in the formation of a long-term effect in the period from 2 to 19 days after exposure was not revealed.
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Analysis of the heart rate in a model test organism daphniamagna as a new approach to the assessment of radioecological effects of irradiation / Morozova, A.O. [et al.] // Izvestiya Wysshikh Uchebnykh Zawedeniy, Yadernaya Energetika. - 2020. - 2. - P. 146-155. - 10.26583/NPE.2020.2.13
URI
https://www.doi.org/10.26583/NPE.2020.2.13
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85091375745&origin=resultslist
 https://openrepository.mephi.ru/handle/123456789/22386
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