Publication:
Antibacterial Effect of Acoustic Cavitation Promoted by Mesoporous Silicon Nanoparticles

Файлы
W4313640516.pdf(1.69 MB)
Дата
2023
Авторы
Sviridov, A.
Mazina, S.
Ostapenko, A.
Timoshenko, V.
Journal Title
Journal ISSN
Volume Title
Издатель
Научные группы
Организационные подразделения
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Организационная единица
Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
Выпуск журнала
Аннотация
As-prepared mesoporous silicon nanoparticles, which were synthesized by electrochemical etching of crystalline silicon wafers followed by high-energy milling in water, were explored as a sonosensitizer in aqueous media under irradiation with low-intensity ultrasound at 0.88 MHz. Due to the mixed oxide-hydride coating of the nanoparticles’ surfaces, they showed both acceptable colloidal stability and sonosensitization of the acoustic cavitation. The latter was directly measured and quantified as a cavitation energy index, i.e., time integral of the magnitude of ultrasound subharmonics. The index turned out to be several times greater for nanoparticle suspensions as compared to pure water, and it depended nonmonotonically on nanoparticle concentration. In vitro tests with Lactobacillus casei revealed a dramatic drop of the bacterial viability and damage of the cells after ultrasonic irradiation with intensity of about 1 W/cm2 in the presence of nanoparticles, which themselves are almost non-toxic at the studied concentrations of about 1 mg/mL. The experimental results prove that nanoparticle-sensitized cavitation bubbles nearby bacteria can cause bacterial lysis and death. The sonosensitizing properties of freshly prepared mesoporous silicon nanoparticles are beneficial for their application in mild antibacterial therapy and treatment of liquid media.
Описание
Ключевые слова
Nanoparticles , Porous Silicon , Sonochemistry , Ultrasound
Цитирование
Antibacterial Effect of Acoustic Cavitation Promoted by Mesoporous Silicon Nanoparticles / Sviridov, A. [et al.] // International Journal of Molecular Sciences. - 2023. - 24. - № 2. - 10.3390/ijms24021065
URI
https://www.doi.org/10.3390/ijms24021065
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85146586770&origin=resultslist
 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000915117200001
 https://openrepository.mephi.ru/handle/123456789/29938
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