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Express high-sensitive detection of ochratoxin A in food by a lateral flow immunoassay based on magnetic biolabels

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dc.contributor.authorOrlov, A. V.
dc.contributor.authorZnoyko, S. L.
dc.contributor.authorMalkerov, J. A.
dc.contributor.authorNovichikhin, D. O.
dc.contributor.authorNikitin, P. I.
dc.contributor.authorНикитин, Петр Иванович
dc.date.accessioned2024-12-26T08:58:24Z
dc.date.available2024-12-26T08:58:24Z
dc.date.issued2022
dc.description.abstract© 2022 Elsevier LtdWe present an easy-to-use lateral flow immunoassay for rapid, precise and sensitive quantification of one of the most hazardous mycotoxins – ochratoxin A (OTA), which is widely present in food and agricultural commodities. The achieved limit of detection during the 20-min OTA registration is 11 pg/mL. The assay provides accurate results in both low- and high-concentration ranges. That is due to the extraordinary steepness of the linear calibration plot: 5-order dynamic range of concentrations causes almost a 1000-fold change in the signal obtained by electronic detection of magnetic biolabels using their non-linear magnetization. High specificity, repeatability, and reproducibility of the assay have been verified, including measuring OTA in real samples of contaminated corn flour. The developed assay is a promising analytical tool for food and feed safety control; it may become an express, convenient and high-precision alternative to the traditional sophisticated laboratory techniques based on liquid chromatography.
dc.identifier.citationExpress high-sensitive detection of ochratoxin A in food by a lateral flow immunoassay based on magnetic biolabels / Orlov, A.V. [et al.] // Food Chemistry. - 2022. - 383. - 10.1016/j.foodchem.2022.132427
dc.identifier.doi10.1016/j.foodchem.2022.132427
dc.identifier.urihttps://www.doi.org/10.1016/j.foodchem.2022.132427
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85125533322&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000819867300010
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/28787
dc.relation.ispartofFood Chemistry
dc.titleExpress high-sensitive detection of ochratoxin A in food by a lateral flow immunoassay based on magnetic biolabels
dc.typeArticle
dspace.entity.typePublication
oaire.citation.volume383
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