Персона: Грязнова, Ольга Юрьевна
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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- ПубликацияТолько метаданныеLaser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal In Vivo Imaging and In Vitro Photothermal Therapy(2022) Komlev, A. S.; Gorin, D. A.; Griaznova, O. Yu.; Belyaev, I. B.; Sogomonyan, A. S.; Zelepukin, I. V.; Tikhonowski, G. V.; Popov, A. A.; Nikitin, P. I.; Kabashin, A. V.; Deyev, S. M.; Грязнова, Ольга Юрьевна; Согомонян, Анна Самвеловна; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Никитин, Петр Иванович; Кабашин, Андрей Викторович; Деев, Сергей Михайлович© 2022 by the authors. Licensee MDPI, Basel, Switzerland.Hybrid multimodal nanoparticles, applicable simultaneously to the noninvasive imaging and therapeutic treatment, are highly demanded for clinical use. Here, Fe-Au core-satellite nanoparticles prepared by the method of pulsed laser ablation in liquids were evaluated as dual magnetic resonance imaging (MRI) and computed tomography (CT) contrast agents and as sensitizers for laser-induced hyperthermia of cancer cells. The biocompatibility of Fe-Au nanoparticles was improved by coating with polyacrylic acid, which provided excellent colloidal stability of nanoparticles with highly negative ζ-potential in water (−38 ± 7 mV) and retained hydrodynamic size (88 ± 20 nm) in a physiological environment. The ferromagnetic iron cores offered great contrast in MRI images with r2 = 11.8 ± 0.8 mM−1 s−1 (at 1 T), while Au satellites showed X-ray attenuation in CT. The intravenous injection of nanoparticles enabled clear tumor border visualization in mice. Plasmonic peak in the Fe-Au hybrids had a tail in the near-infrared region (NIR), allowing them to cause hyperthermia under 808 nm laser exposure. Under NIR irradiation Fe-Au particles provided 24.1 °C/W heating and an IC50 value below 32 µg/mL for three different cancer cell lines. Taken together, these results show that laser synthesized Fe-Au core-satellite nanoparticles are excellent theranostic agents with multimodal imaging and photothermal capabilities.
- ПубликацияТолько метаданныеMIL-53 (Al) metal-organic frameworks as potential drug carriers(2021) Kolokolnikov, V. N.; Griaznova, O. Yu.; Zelepukin, I. V.; Tikhonowski, G. V.; Deyev, S. M.; Грязнова, Ольга Юрьевна; Тихоновский, Глеб Валерьевич; Деев, Сергей Михайлович© 2021 Institute of Physics Publishing. All rights reserved.One of the challenges of the medicine is to improve the chemical stability of drugs and to prevent their premature biodegradation before reaching the therapeutic target. Various nanoparticles were used to solve this problem, but low drug loading efficiency limited their biomedical applications. Metal organic frameworks are promising candidates for drug delivery since they have extremely high surface area and regular porosity. In this study, we prepared high-crystalline MIL-53 frameworks based on aluminium and 2-aminoterephtalic acid by microwave-assisted synthesis and evaluated their properties as drug carriers. Drug loading of chemotherapeutic and diagnostic molecules of different nature riches value of 34% by particle weight, significantly higher than those of other reported solid nanoparticles. Therefore, our results make MIL-53 (Al) frameworks promising candidate for drug delivery.
- ПубликацияТолько метаданныеPhotoinduced Toxicity Caused by Gold Nanozymes and Photodynamic Dye Encapsulated in Submicron Polymer Shell(2024) Sergeev, I. S.; Maksimova, E. A.; Moiseeva, E. O.; Griaznova, O. Yu.; Deyev, S. M.; Грязнова, Ольга Юрьевна; Деев, Сергей Михайлович