Персона: Кабашин, Андрей Викторович
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Руководитель научной группы "Лаборатория «Бионанофотоники"
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Кабашин
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Андрей Викторович
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- ПубликацияОткрытый доступNuclear nanomedicine using Si nanoparticles as safe and effective carriers of 188 Re radionuclide for cancer therapy(2019) Tischenko, V. K.; Mikhailovskaya, A. A.; Popov, A. A.; Tselikov, G.; Petriev, V. M.; Deyev, S. M.; Timoshenko, V. Y.; Prasad, P. N.; Zavestovskaya, I. N.; Kabashin, A. V.; Деев, Сергей Михайлович; Тимошенко, Виктор Юрьевич; Завестовская, Ирина Николаевна; Кабашин, Андрей Викторович© 2019, The Author(s). Nuclear nanomedicine, with its targeting ability and heavily loading capacity, along with its enhanced retention to avoid rapid clearance as faced with molecular radiopharmaceuticals, provides unique opportunities to treat tumors and metastasis. Despite these promises, this field has seen limited activities, primarily because of a lack of suitable nanocarriers, which are safe, excretable and have favorable pharmacokinetics to efficiently deliver and retain radionuclides in a tumor. Here, we introduce biodegradable laser-synthesized Si nanoparticles having round shape, controllable low-dispersion size, and being free of any toxic impurities, as highly suitable carriers of therapeutic 188 Re radionuclide. The conjugation of the polyethylene glycol-coated Si nanoparticles with radioactive 188 Re takes merely 1 hour, compared to its half-life of 17 hours. When intravenously administered in a Wistar rat model, the conjugates demonstrate free circulation in the blood stream to reach all organs and target tumors, which is radically in contrast with that of the 188 Re salt that mostly accumulates in the thyroid gland. We also show that the nanoparticles ensure excellent retention of 188 Re in tumor, not possible with the salt, which enables one to maximize the therapeutic effect, as well as exhibit a complete time-delayed conjugate bioelimination. Finally, our tests on rat survival demonstrate excellent therapeutic effect (72% survival compared to 0% of the control group). Combined with a series of imaging and therapeutic functionalities based on unique intrinsic properties of Si nanoparticles, the proposed biodegradable complex promises a major advancement in nuclear nanomedicine.
- ПубликацияОткрытый доступPhase-Responsive Fourier Nanotransducers for Probing 2D Materials and Functional Interfaces(2019) Kravets, V. G.; Wu, F.; Imaizumi, S.; Grigorenko, A. N.; Kabashin, A. V.; Shipunova, V. O.; Deyev, S. M.; Кабашин, Андрей Викторович; Деев, Сергей Михайлович© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Light scattered by an object contains plethora information about the object which is distributed evenly among all possible Fourier components of light observed in the far-field. There are some cases, however, where this information is accumulated in the light confined by the object and then encoded in just a few coherent optical beams. Here, Fourier nanotransducers based on 2D plasmonic metamaterials are introduced, which are capable of confining light in 2D plane contacting with a functional interface, gathering information about its properties, and then transmitting the information into discrete optical beams with amplified phase relations. It is shown that phase of light in such beams can be used for probing dynamic physical properties of 2D materials and performing bio/chemical sensing with unprecedented sensitivity. Using a Fourier transducer based on periodic gold nanostructures, ferroelectric response from a single atomic layer of MoS 2 is resolved and studied for the first time, as well as the detection of important antibiotic chloramphenicol at fg mL −1 level is demonstrated, which several orders of magnitude better than reported in the literature. The implementation of phase-responsive Fourier nanotransducers opens new avenues in exploration of emergent 2D structures and radical improvement of biosensing technology.
- ПубликацияОткрытый доступLaser-ablative synthesis of isotope-enriched samarium oxide nanoparticles for nuclear nanomedicine(2020) Duflot, V.; Popova-Kuznetsova, E.; Tikhonowski, G.; Popov, A. A.; Deyev, S.; Klimentov, S.; Zavestovskaya, I.; Prasad, P. N.; Kabashin, A. V.; Попова-Кузнецова, Елена Алефтиновна; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Деев, Сергей Михайлович; Климентов, Сергей Михайлович; Завестовская, Ирина Николаевна; Кабашин, Андрей Викторович© 2019 by the authors. Licensee MDPI, Basel, Switzerland.Nuclear nanomedicine is an emerging field, which utilizes nanoformulations of nuclear agents to increase their local concentration at targeted sites for a more effective nuclear therapy at a considerably reduced radiation dosage. This field needs the development of methods for controlled fabrication of nuclear agents carrying nanoparticles with low polydispersity and with high colloidal stability in aqueous dispersions. In this paper, we apply methods of femtosecond (fs) laser ablation in deionized water to fabricate stable aqueous dispersion of152Sm-enriched samarium oxide nanoparticles (NPs), which can capture neutrons to become153Sm beta-emitters for nuclear therapy. We show that direct ablation of a152Sm-enriched samarium oxide target leads to widely size-and shape-dispersed populations of NPs with low colloidal stability. However, by applying a second fs laser fragmentation step to the dispersion of initially formed colloids, we achieve full homogenization of NPs size characteristics, while keeping the same composition. We also demonstrate the possibility for wide-range tuning of the mean size of Sm-based NPs by varying laser energy during the ablation or fragmentation step. The final product presents dispersed solutions of samarium oxide NPs with relatively narrow size distribution, having spherical shape, a controlled mean size between 7 and 70 nm and high colloidal stability. The formed NPs can also be of importance for catalytic and biomedical applications.